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. Author manuscript; available in PMC: 2008 Mar 15.
Published in final edited form as: Virology. 2006 Oct 31;359(2):283–294. doi: 10.1016/j.virol.2006.09.034

Figure 1. Possible pathways leading to the development of HCC in chronically WHV-infected woodchucks.

Figure 1

Three major types of FAH, basophilic, amphophilic and clear cell are thought to arise from normal hepatocytes during chronic WHV infection. These FAH generally express undetectable or reduced levels of WHV compared to WHV-infected hepatocytes. A fourth type of focus, which contains morphologically normal hepatocytes but also fails to express WHV, is described in this study.