Abstract
Caffeine elimination was studied in 15 women at 38 to 40 weeks' gestation. The mean hourly caffeine clearance, 37 ml/kg, determined from assays of saliva, was only 39% of the value previously reported for nonpregnant adults (94 ml/kg). Reassessment in four of the women 2 to 12 weeks post partum showed that in each woman the caffeine clearance had increased more than threefold and that the mean caffeine concentration in the saliva after no intake of caffeine for 24 hours was now much lower (0.07 v. 0.84 microgram/ml).
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AXELROD J., REICHENTHAL J. The fate of caffeine in man and a method for its estimation in biological material. J Pharmacol Exp Ther. 1953 Apr;107(4):519–523. [PubMed] [Google Scholar]
- Burg A. W. Physiological disposition of caffeine. Drug Metab Rev. 1975;4(2):199–228. doi: 10.3109/03602537508993756. [DOI] [PubMed] [Google Scholar]
- CORNISH H. H., CHRISTMAN A. A. A study of the metabolism of theobromine, theophylline, and caffeine in man. J Biol Chem. 1957 Sep;228(1):315–323. [PubMed] [Google Scholar]
- Cook C. E., Tallent C. R., Amerson E. W., Myers M. W., Kepler J. A., Taylor G. F., Christensen H. D. Caffeine in plasma and saliva by a radioimmunoassay procedure. J Pharmacol Exp Ther. 1976 Dec;199(3):679–686. [PubMed] [Google Scholar]
- Crawford J. S., Rudofsky S. Some alterations in the pattern of drug metabolism aociated with pegnancy, oral contraceptives, and the newly-born. Br J Anaesth. 1966 Jun;38(6):446–454. doi: 10.1093/bja/38.6.446. [DOI] [PubMed] [Google Scholar]
- Feuer G., Kardish R. Hormonal regulation of drug metabolism during pregnancy. Int J Clin Pharmacol Biopharm. 1975 Jun;11(4):366–374. [PubMed] [Google Scholar]
- Linn S., Schoenbaum S. C., Monson R. R., Rosner B., Stubblefield P. G., Ryan K. J. No association between coffee consumption and adverse outcomes of pregnancy. N Engl J Med. 1982 Jan 21;306(3):141–145. doi: 10.1056/NEJM198201213060304. [DOI] [PubMed] [Google Scholar]
- Mygind K. I., Dam M., Christiansen J. Phenytoin and phenobarbitone plasma clearance during pregnancy. Acta Neurol Scand. 1976 Aug;54(2):160–166. doi: 10.1111/j.1600-0404.1976.tb04789.x. [DOI] [PubMed] [Google Scholar]
- Parsons W. D., Neims A. H. Effect of smoking on caffeine clearance. Clin Pharmacol Ther. 1978 Jul;24(1):40–45. doi: 10.1002/cpt197824140. [DOI] [PubMed] [Google Scholar]
- Parsons W. D., Neims A. H. Prolonged half-life of caffeine in healthy tem newborn infants. J Pediatr. 1981 Apr;98(4):640–641. doi: 10.1016/s0022-3476(81)80784-6. [DOI] [PubMed] [Google Scholar]
- Patwardhan R. V., Desmond P. V., Johnson R. F., Schenker S. Impaired elimination of caffeine by oral contraceptive steroids. J Lab Clin Med. 1980 Apr;95(4):603–608. [PubMed] [Google Scholar]
- Statland B. E., Demas T., Danis M. Letter: Caffeine accumulation associated with alcoholic liver disease. N Engl J Med. 1976 Jul 8;295(2):110–111. [PubMed] [Google Scholar]
- Weathersbee P. S., Olsen L. K., Lodge J. R. Caffeine and pregnancy. A retrospective survey. Postgrad Med. 1977 Sep;62(3):64–69. doi: 10.1080/00325481.1977.11714605. [DOI] [PubMed] [Google Scholar]
