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. 1994 Mar;62(3):948–955. doi: 10.1128/iai.62.3.948-955.1994

The signal transduction mechanism responsible for gamma interferon-induced indoleamine 2,3-dioxygenase gene expression.

Y Koide 1, A Yoshida 1
PMCID: PMC186208  PMID: 8112868

Abstract

We examined the signal transduction mechanism responsible for the gamma interferon-induced indoleamine 2,3-dioxygenase (IDO) gene expression in a human monocytic cell line, THP-1. Our results suggest that gamma interferon-induced activation of protein tyrosine kinase is a prerequisite for gene expression and that activation of protein kinase C and another unknown signal(s), both of which are transduced by the protein tyrosine kinase, synergistically induce IDO gene expression. Neither Ca2+ influx nor cyclic nucleotide-dependent kinases were suggested to be involved in the signaling pathway.

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