Abstract
To determine the prevalence of hepatitis A in a Canadian Inuit population, serum from 85% of the 850 inhabitants of Baker Lake, Northwest Territories, was tested by radioimmunoassay for antibody to the hepatitis A virus (anti-HAV). The overall prevalence of anti-HAV in the community was 71%. Exposure to the virus occurred early in life, such that by the age of 6 years 53% of the children had anti-HAV in their serum. The rate approached 100% by the age of 50 years. These findings document the ubiquitous nature of the hepatitis A virus in this northern Inuit settlement and suggest that immunoprophylaxis be considered for individuals taking short-term employment in such places.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barin F., Denis F., Chotard J., Paulin R., Chiron J. P., Maupas P., Goudeau A., Coursaget P. Early asymptomatic hepatitis A in Senegalese children. Lancet. 1980 Jan 26;1(8161):212–213. doi: 10.1016/s0140-6736(80)90706-0. [DOI] [PubMed] [Google Scholar]
- Dienstag J. L., Szmuness W., Stevens C. E., Purcell R. H. Hepatitis A virus infection: new insights from seroepidemiologic studies. J Infect Dis. 1978 Mar;137(3):328–340. doi: 10.1093/infdis/137.3.328. [DOI] [PubMed] [Google Scholar]
- Hall W. T., Madden D. L., Mundon F. K., Brandt D. E., Clarke N. A. Protective effect of immune serum globulin (ISG) against hepatitis A infection in a natural epidemic. Am J Epidemiol. 1977 Jul;106(1):72–75. doi: 10.1093/oxfordjournals.aje.a112435. [DOI] [PubMed] [Google Scholar]
- Matthew E. B., Dietzman D. E., Madden D. L., Newman S. J., Sever J. L., Nagler B., Bouton S. M., Rostafinski M. A major epidmeic of infectious hepatitis in an institution for the mentally retarded. Am J Epidemiol. 1973 Sep;98(3):199–215. doi: 10.1093/oxfordjournals.aje.a121549. [DOI] [PubMed] [Google Scholar]
- McFarlane E. S., Embil J. A., Manuel F. R., Gorelick M. Prevalence of antibodies to hepatitis A antigen in patients attending a clinic for treatment of sexually transmitted diseases. Sex Transm Dis. 1980 Apr-Jun;7(2):87–89. doi: 10.1097/00007435-198004000-00011. [DOI] [PubMed] [Google Scholar]
- McFarlane E. S., Embil J. A. Prevalence of antibodies to Hepatitis A antigen in sera from patients with haematological malignancies. J Med Virol. 1981;8(1):49–53. doi: 10.1002/jmv.1890080104. [DOI] [PubMed] [Google Scholar]
- Miller W. J., Provost P. J., McAleer W. J., Ittensohn O. L., Villarejos V. M., Hilleman M. R. Specific immune adherence assay for human hepatitis A antibody application to diagnostic and epidemiologic investigations. Proc Soc Exp Biol Med. 1975 May;149(1):254–261. doi: 10.3181/00379727-149-38783. [DOI] [PubMed] [Google Scholar]
- Provost P. J., Wolanski B. S., Miller W. J., Ittensohn O. L., McAleer W. J., Hilleman M. R. Physical, chemical and morphologic dimensions of human hepatitis A virus strain CR326 (38578). Proc Soc Exp Biol Med. 1975 Feb;148(2):532–539. doi: 10.3181/00379727-148-38578. [DOI] [PubMed] [Google Scholar]
- Purcell R. H., Wong D. C., Moritsugu Y., Dienstag J. L., Routenberg J. A., Boggs J. D. A microtiter solid-phase radioimmunoassay for hepatitis A antigen and antibody. J Immunol. 1976 Feb;116(2):349–356. [PubMed] [Google Scholar]
- Skinhoj P., Mikkelsen F., Hollinger F. B. Hepatitis Ain Greenland: importance of specific antibody testing in epidemiologic surveillance. Am J Epidemiol. 1977 Feb;105(2):140–147. doi: 10.1093/oxfordjournals.aje.a112366. [DOI] [PubMed] [Google Scholar]
- Skinhøj P., Aldershvile J., Black F., Kjersem H., Kryger P., Mathiesen L. Viral hepatitis in southeast Asian refugees. J Med Virol. 1981;7(2):149–155. doi: 10.1002/jmv.1890070209. [DOI] [PubMed] [Google Scholar]
- Szmuness W., Dienstag J. L., Purcell R. H., Harley E. J., Stevens C. E., Wong D. C. Distribution of antibody to hepatitis a antigen in urban adult populations. N Engl J Med. 1976 Sep 30;295(14):755–759. doi: 10.1056/NEJM197609302951404. [DOI] [PubMed] [Google Scholar]
- Szmuness W., Dienstag J. L., Purcell R. H., Stevens C. E., Wong D. C., Ikram H., Bar-Shany S., Beasley R. P., Desmyter J., Gaon J. A. The prevalence of antibody to hepatitis A antigen in various parts of the world: a pilot study. Am J Epidemiol. 1977 Nov;106(5):392–398. doi: 10.1093/oxfordjournals.aje.a112481. [DOI] [PubMed] [Google Scholar]
- Villarejos V. M., Provost P. J., Ittensohn O. L., McLean A. A., Hilleman M. R. Seroepidemiologic investigations of human hepatitis caused by A, B, and a possible third virus. Proc Soc Exp Biol Med. 1976 Sep;152(4):524–528. doi: 10.3181/00379727-152-39432. [DOI] [PubMed] [Google Scholar]