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. 1982 Nov 1;127(9):850–852.

Prevalence of antibody to hepatitis A virus in a Canadian Inuit community.

G Y Minuk, J G Waggoner, R Jernigan, L E Nicolle, B Postl, J H Hoofnagle
PMCID: PMC1862238  PMID: 7139503

Abstract

To determine the prevalence of hepatitis A in a Canadian Inuit population, serum from 85% of the 850 inhabitants of Baker Lake, Northwest Territories, was tested by radioimmunoassay for antibody to the hepatitis A virus (anti-HAV). The overall prevalence of anti-HAV in the community was 71%. Exposure to the virus occurred early in life, such that by the age of 6 years 53% of the children had anti-HAV in their serum. The rate approached 100% by the age of 50 years. These findings document the ubiquitous nature of the hepatitis A virus in this northern Inuit settlement and suggest that immunoprophylaxis be considered for individuals taking short-term employment in such places.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barin F., Denis F., Chotard J., Paulin R., Chiron J. P., Maupas P., Goudeau A., Coursaget P. Early asymptomatic hepatitis A in Senegalese children. Lancet. 1980 Jan 26;1(8161):212–213. doi: 10.1016/s0140-6736(80)90706-0. [DOI] [PubMed] [Google Scholar]
  2. Dienstag J. L., Szmuness W., Stevens C. E., Purcell R. H. Hepatitis A virus infection: new insights from seroepidemiologic studies. J Infect Dis. 1978 Mar;137(3):328–340. doi: 10.1093/infdis/137.3.328. [DOI] [PubMed] [Google Scholar]
  3. Hall W. T., Madden D. L., Mundon F. K., Brandt D. E., Clarke N. A. Protective effect of immune serum globulin (ISG) against hepatitis A infection in a natural epidemic. Am J Epidemiol. 1977 Jul;106(1):72–75. doi: 10.1093/oxfordjournals.aje.a112435. [DOI] [PubMed] [Google Scholar]
  4. Matthew E. B., Dietzman D. E., Madden D. L., Newman S. J., Sever J. L., Nagler B., Bouton S. M., Rostafinski M. A major epidmeic of infectious hepatitis in an institution for the mentally retarded. Am J Epidemiol. 1973 Sep;98(3):199–215. doi: 10.1093/oxfordjournals.aje.a121549. [DOI] [PubMed] [Google Scholar]
  5. McFarlane E. S., Embil J. A., Manuel F. R., Gorelick M. Prevalence of antibodies to hepatitis A antigen in patients attending a clinic for treatment of sexually transmitted diseases. Sex Transm Dis. 1980 Apr-Jun;7(2):87–89. doi: 10.1097/00007435-198004000-00011. [DOI] [PubMed] [Google Scholar]
  6. McFarlane E. S., Embil J. A. Prevalence of antibodies to Hepatitis A antigen in sera from patients with haematological malignancies. J Med Virol. 1981;8(1):49–53. doi: 10.1002/jmv.1890080104. [DOI] [PubMed] [Google Scholar]
  7. Miller W. J., Provost P. J., McAleer W. J., Ittensohn O. L., Villarejos V. M., Hilleman M. R. Specific immune adherence assay for human hepatitis A antibody application to diagnostic and epidemiologic investigations. Proc Soc Exp Biol Med. 1975 May;149(1):254–261. doi: 10.3181/00379727-149-38783. [DOI] [PubMed] [Google Scholar]
  8. Provost P. J., Wolanski B. S., Miller W. J., Ittensohn O. L., McAleer W. J., Hilleman M. R. Physical, chemical and morphologic dimensions of human hepatitis A virus strain CR326 (38578). Proc Soc Exp Biol Med. 1975 Feb;148(2):532–539. doi: 10.3181/00379727-148-38578. [DOI] [PubMed] [Google Scholar]
  9. Purcell R. H., Wong D. C., Moritsugu Y., Dienstag J. L., Routenberg J. A., Boggs J. D. A microtiter solid-phase radioimmunoassay for hepatitis A antigen and antibody. J Immunol. 1976 Feb;116(2):349–356. [PubMed] [Google Scholar]
  10. Skinhoj P., Mikkelsen F., Hollinger F. B. Hepatitis Ain Greenland: importance of specific antibody testing in epidemiologic surveillance. Am J Epidemiol. 1977 Feb;105(2):140–147. doi: 10.1093/oxfordjournals.aje.a112366. [DOI] [PubMed] [Google Scholar]
  11. Skinhøj P., Aldershvile J., Black F., Kjersem H., Kryger P., Mathiesen L. Viral hepatitis in southeast Asian refugees. J Med Virol. 1981;7(2):149–155. doi: 10.1002/jmv.1890070209. [DOI] [PubMed] [Google Scholar]
  12. Szmuness W., Dienstag J. L., Purcell R. H., Harley E. J., Stevens C. E., Wong D. C. Distribution of antibody to hepatitis a antigen in urban adult populations. N Engl J Med. 1976 Sep 30;295(14):755–759. doi: 10.1056/NEJM197609302951404. [DOI] [PubMed] [Google Scholar]
  13. Szmuness W., Dienstag J. L., Purcell R. H., Stevens C. E., Wong D. C., Ikram H., Bar-Shany S., Beasley R. P., Desmyter J., Gaon J. A. The prevalence of antibody to hepatitis A antigen in various parts of the world: a pilot study. Am J Epidemiol. 1977 Nov;106(5):392–398. doi: 10.1093/oxfordjournals.aje.a112481. [DOI] [PubMed] [Google Scholar]
  14. Villarejos V. M., Provost P. J., Ittensohn O. L., McLean A. A., Hilleman M. R. Seroepidemiologic investigations of human hepatitis caused by A, B, and a possible third virus. Proc Soc Exp Biol Med. 1976 Sep;152(4):524–528. doi: 10.3181/00379727-152-39432. [DOI] [PubMed] [Google Scholar]

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