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. 1994 Mar;62(3):1118–1120. doi: 10.1128/iai.62.3.1118-1120.1994

Isotype and antigen specificity of pertussis agglutinins following whole-cell pertussis vaccination and infection with Bordetella pertussis.

C M Mink 1, C H O'Brien 1, S Wassilak 1, A Deforest 1, B D Meade 1
PMCID: PMC186231  PMID: 7509316

Abstract

Elevated agglutinin titers have been shown to correlate with protection from disease following whole-cell pertussis vaccination, but the isotype and antigen specificity of human agglutinating antibodies is unknown. In 13 immunoassays, immunoglobulin G antifimbria antibodies had the strongest correlation with agglutinin titers following culture-proven infection with Bordetella pertussis (R' = 0.79; P < 0.0001) and following whole-cell pertussis vaccination (R' = 0.87, P < 0.0001).

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Selected References

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