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. 1994 Apr;62(4):1171–1175. doi: 10.1128/iai.62.4.1171-1175.1994

Binding of lysozyme to lipopolysaccharide suppresses tumor necrosis factor production in vivo.

K Takada 1, N Ohno 1, T Yadomae 1
PMCID: PMC186250  PMID: 8132323

Abstract

Endotoxin (lipopolysaccharide [LPS]) released during gram-negative bacterial infection induces varieties of cytokines which directly and/or indirectly cause shock, disseminated intravascular coagulation, and death. We previously showed that lysozyme (LZM) was an LPS-binding protein and inhibited various immunomodulating activities of LPS. In this study, we examined the effect of LZM on the LPS-triggered septic shock model induced by carrageenan treatment and assessed by tumor necrosis factor production. The data presented in this report strongly suggest that LZM-LPS complex formation completely abrogates tumor necrosis factor production and the mortality caused by LPS and that LZM may be useful for the treatment of endotoxin shock.

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Selected References

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