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. 1981 Dec 15;125(12):1336–1338.

Relation of oral dose of oxtriphylline to serum theophylline level.

G H Guyatt, S D Desai
PMCID: PMC1862761  PMID: 7034918

Abstract

Serum theophylline levels were studied in relation to oral doses of oxtriphylline in 30 patients with reversible airway obstruction. A wide scattering of levels was observed and was attributed to widely differing rates of metabolism of the drug. From the data obtained it was concluded that the most commonly prescribed daily dose of oxtriphylline, 800 mg, will produce a therapeutic level of theophylline in only about one quarter of patients. A daily starting dose of 15 to 20 mg/kg, however, will produce therapeutic levels in approximately one third of patients without significant toxic effects. Once the patient's conditions is stable the serum theophylline concentration should be measured; if it is subtherapeutic the dose of oxtriphylline should be increased slowly and the serum theophylline concentration remeasured until a level of 10 to 20 microgram/ml is achieved.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Eney R. D., Goldstein E. O. Compliance of chronic asthmatics with oral administration of theophylline as measured by serum and salivary levels. Pediatrics. 1976 Apr;57(4):513–517. [PubMed] [Google Scholar]
  2. Hendeles L., Weinberger M., Bighley L. Disposition of theophylline after a single intravenous infusion of aminophylline. Am Rev Respir Dis. 1978 Jul;118(1):97–103. doi: 10.1164/arrd.1978.118.1.97. [DOI] [PubMed] [Google Scholar]
  3. Hendeles L., Weinberger M., Wyatt R. Guide to oral theophylline therapy for the treatment of chronic asthma. Am J Dis Child. 1978 Sep;132(9):876–880. [PubMed] [Google Scholar]
  4. Hunt S. N., Jusko W. J., Yurchak A. M. Effect of smoking on theophylline disposition. Clin Pharmacol Ther. 1976 May;19(5 Pt 1):546–551. doi: 10.1002/cpt1976195part1546. [DOI] [PubMed] [Google Scholar]
  5. JACKSON R. H., MCHENRY J. I., MORELAND F. B., RAYMER W. J., ETTER R. L. CLINICAL EVALUATION OF ELIXOPHYLLIN WITH CORRELATION OF PULMONARY FUNCTION STUDIES AND THEOPHYLLINE SERUM LEVELS IN ACUTE AND CHRONIC ASTHMATIC PATIENTS. Dis Chest. 1964 Jan;45:75–85. doi: 10.1378/chest.45.1.75. [DOI] [PubMed] [Google Scholar]
  6. Jacobs M. H., Senior R. M., Kessler G. Clinical experience with theophylline. Relarionships between dosage, serum concentration, and toxicity. JAMA. 1976 May 3;235(18):1983–1986. doi: 10.1001/jama.235.18.1983. [DOI] [PubMed] [Google Scholar]
  7. Jenne J. W., Wyze M. S., Rood F. S., MacDonald F. M. Pharmacokinetics of theophylline. Application to adjustment of the clinical dose of aminophylline. Clin Pharmacol Ther. 1972 May-Jun;13(3):349–360. doi: 10.1002/cpt1972133349. [DOI] [PubMed] [Google Scholar]
  8. Jusko W. J., Schentag J. J., Clark J. H., Gardner M., Yurchak A. M. Enhanced biotransformation of theophylline in marihuana and tobacco smokers. Clin Pharmacol Ther. 1978 Oct;24(4):405–410. [PubMed] [Google Scholar]
  9. Leung P., Katsampes C., Bell T. Pharmacokinetics of delayed (DR) versus sustained release (SR) theophylline formulations following single (SD) and repetitive dosing (RD). Ann Allergy. 1978 Nov;41(5):285–287. [PubMed] [Google Scholar]
  10. Levy G., Koysooko R. Pharmacokinetic analysis of the effect of theophylline on pulmonary function in asthmatic children. J Pediatr. 1975 May;86(5):789–793. doi: 10.1016/s0022-3476(75)80374-x. [DOI] [PubMed] [Google Scholar]
  11. Mangione A., Imhoff T. E., Lee R. V., Shum L. Y., Jusko W. J. Pharmacokinetics of theophylline in hepatic disease. Chest. 1978 May;73(5):616–622. doi: 10.1378/chest.73.5.616. [DOI] [PubMed] [Google Scholar]
  12. Mitenko P. A., Ogilvie R. I. Rational intravenous doses of theophylline. N Engl J Med. 1973 Sep 20;289(12):600–603. doi: 10.1056/NEJM197309202891202. [DOI] [PubMed] [Google Scholar]
  13. Ogilvie R. I. Smoking and theophylline dose schedules. Ann Intern Med. 1978 Feb;88(2):263–264. doi: 10.7326/0003-4819-88-2-263_2. [DOI] [PubMed] [Google Scholar]
  14. Piafsky K. M., Ogilvie R. I. Dosage of theophylline in bronchial asthma. N Engl J Med. 1975 Jun 5;292(23):1218–1222. doi: 10.1056/NEJM197506052922305. [DOI] [PubMed] [Google Scholar]
  15. Piafsky K. M., Sitar D. S., Rangno R. E., Ogilvie R. I. Theophylline disposition in patients with hepatic cirrhosis. N Engl J Med. 1977 Jun 30;296(26):1495–1497. doi: 10.1056/NEJM197706302962603. [DOI] [PubMed] [Google Scholar]
  16. Piafsky K. M., Sitar D. S., Rangno R. E., Ogilvie R. I. Theophylline kinetics in acute pulmonary edema. Clin Pharmacol Ther. 1977 Mar;21(3):310–316. doi: 10.1002/cpt1977213310. [DOI] [PubMed] [Google Scholar]
  17. Sitar D. S., Nadeau J. H., Ruedy J. R. Comparative bioavailability of two oral dosage forms of oxtriphylline. Curr Ther Res Clin Exp. 1977 Feb;21(2):233–240. [PubMed] [Google Scholar]
  18. TURNER-WARWICK M. Study of theophylline plasma levels after oral administration of new theophylline compounds. Br Med J. 1957 Jul 13;2(5036):67–69. doi: 10.1136/bmj.2.5036.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Van Dellen R. G. Intravenous aminophylline. Chest. 1979 Jul;76(1):2–3. doi: 10.1378/chest.76.1.2. [DOI] [PubMed] [Google Scholar]
  20. Weinberger M., Hendeles L., Bighley L. The relation of product formulation to absorption of oral theophylline. N Engl J Med. 1978 Oct 19;299(16):852–857. doi: 10.1056/NEJM197810192991603. [DOI] [PubMed] [Google Scholar]
  21. Wyatt R., Weinberger M., Hendeles L. Oral theophylline dosage for the management of chronic asthma. J Pediatr. 1978 Jan;92(1):125–130. doi: 10.1016/s0022-3476(78)80093-6. [DOI] [PubMed] [Google Scholar]
  22. Zwillich C. W., Sutton F. D., Neff T. A., Cohn W. M., Matthay R. A., Weinberger M. M. Theophylline-induced seizures in adults. Correlation with serum concentrations. Ann Intern Med. 1975 Jun;82(6):784–787. doi: 10.7326/0003-4819-82-6-784. [DOI] [PubMed] [Google Scholar]

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