Skip to main content
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1982 Apr 1;126(7):811–813.

Hyperbilirubinemia in Inuit neonates.

B D Postl, N Nelson, J Carson
PMCID: PMC1863113  PMID: 7074475

Abstract

A prospective study was undertaken to determine if Inuit and Caucasian neonates have different patterns of physiologic jaundice. Daily blood samples obtained by heel pricks of Inuit and Caucasian neonates born at the Churchill (Man.) Health Centre were assayed for the total serum bilirubin concentration. The mean peak bilirubin level in the Inuit group was significantly higher than that in the Caucasian group (8.76 v. 6.04 mg/dl [150 v. 103 mumol/l]) and occurred later (on day 3 rather than day 2). Of the Caucasian neonates, those who were breast-fed in hospital had a significantly higher (P less than 0.05) mean peak bilirubin level than those who were not, and among all the neonates who were not breast-fed in hospital the Inuit had a significantly higher mean peak bilirubin level than the Caucasians (7.98 v. 3.64 mg/dl [136 v. 62 mumol/l]). These findings indicate that factors other than breastfeeding, some of which may be genetic, are responsible for the higher and later peak in the serum bilirubin concentration in Inuit neonates.

Full text

PDF
811

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARIAS I. M., GARTNER L. M., SEIFTER S., FURMAN M. PROLONGED NEONATAL UNCONJUGATED HYPERBILIRUBINEMIA ASSOCIATED WITH BREAST FEEDING AND A STEROID, PREGNANE-3(ALPHA), 20(BETA)-DIOL, IN MATERNAL MILK THAT INHIBITS GLUCURONIDE FORMATION IN VITRO. J Clin Invest. 1964 Nov;43:2037–2047. doi: 10.1172/JCI105078. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Amanullah A. Neonatal jaundice. Am J Dis Child. 1976 Nov;130(11):1274–1280. doi: 10.1001/archpedi.1976.02120120108023. [DOI] [PubMed] [Google Scholar]
  3. BROWN A. K. Neonatal jaundice. Pediatr Clin North Am. 1962 Aug;9:575–603. doi: 10.1016/s0031-3955(16)31298-6. [DOI] [PubMed] [Google Scholar]
  4. Beazley J. M., Alderman B. Neonatal hyperbilirubinaemia following the use of oxytocin in labour. Br J Obstet Gynaecol. 1975 Apr;82(4):265–271. doi: 10.1111/j.1471-0528.1975.tb00632.x. [DOI] [PubMed] [Google Scholar]
  5. Brown W. R., Boon W. H. Ethnic group differences in plasma bilirubin levels of full-term, healthy Singapore newborns. Pediatrics. 1965 Nov;36(5):745–751. [PubMed] [Google Scholar]
  6. Dubowitz L. M., Dubowitz V., Goldberg C. Clinical assessment of gestational age in the newborn infant. J Pediatr. 1970 Jul;77(1):1–10. doi: 10.1016/s0022-3476(70)80038-5. [DOI] [PubMed] [Google Scholar]
  7. Fisher Q., Cohen M. I., Curda L., McNamara H. Jaundice and breast-feeding among Alaskan Eskimo newborns. Am J Dis Child. 1978 Sep;132(9):859–861. doi: 10.1001/archpedi.1978.02120340035005. [DOI] [PubMed] [Google Scholar]
  8. HUNT A. L., MOORES P., PLAMPIN D. W. The incidence and severity of jaundice in the newborn in Salisbury, Southern Rhodesia. Cent Afr J Med. 1961 Oct;7:351–355. [PubMed] [Google Scholar]
  9. Horiguchi T., Bauer C. Ethnic differences in neonatal jaundice: comparison of Japanese and Caucasian newborn infants. Am J Obstet Gynecol. 1975 Jan 1;121(1):71–74. doi: 10.1016/0002-9378(75)90978-3. [DOI] [PubMed] [Google Scholar]
  10. Maisels M. J. Bilirubin; on understanding and influencing its metabolism in the newborn infant. Pediatr Clin North Am. 1972 May;19(2):447–501. [PubMed] [Google Scholar]
  11. SHNIER M. H., LEVIN S. E. Hyperbilirubinaemia and kernicterus in premature and full-term Bantu newborn infants. Br Med J. 1959 Apr 18;1(5128):1004–1007. doi: 10.1136/bmj.1.5128.1004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Saland J., McNamara H., Cohen M. I. Navajo jaundice: a variant of neonatal hyperbilirubinemia associated with breast feeding. J Pediatr. 1974 Aug;85(2):271–275. doi: 10.1016/s0022-3476(74)80410-5. [DOI] [PubMed] [Google Scholar]
  13. TAYLOR P. M., BRIGHT N. H., BIRCHARD E. L., DERINOZ M. N., WATSON D. W. THE EFFECTS OF RACE, WEIGHT LOSS AND THE TIME OF CLAMPING OF THE UMBILICAL CORD ON NEONATAL BILIRUBINEMIA. Biol Neonat. 1963;5:299–318. doi: 10.1159/000239877. [DOI] [PubMed] [Google Scholar]
  14. Trolle D. Decrease of total serum-bilirubin concentration in newborn infants after phenobarbitone treatment. Lancet. 1968 Sep 28;2(7570):705–708. doi: 10.1016/s0140-6736(68)90750-2. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES