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. 1994 Apr;62(4):1501–1503. doi: 10.1128/iai.62.4.1501-1503.1994

Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes.

S Houldsworth 1, P W Andrew 1, T J Mitchell 1
PMCID: PMC186313  PMID: 8132361

Abstract

Human peripheral blood monocytes and a human monocyte cell line were exposed to the toxin pneumolysin. Pneumolysin-exposed cells produced significantly larger amounts of tumor necrosis factor alpha and interleukin-1 beta than cells not exposed to the toxin. The viability of cells was not affected by the concentrations of pneumolysin used in the experiments.

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Selected References

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