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. 1982 Jun 15;126(12):1386–1390.

Diagnosis of systemic or visceral candidosis.

P J Kozinn, C L Taschdjian, B E Kodsi, G J Wise, M S Seelig, P K Goldberg
PMCID: PMC1863137  PMID: 7044510

Abstract

Although systemic or visceral candidosis can be diagnosed during life, it is usually discovered at autopsy. Early diagnosis is important since treatment with specific antifungal drugs is effective. The diagnosis should rest on all available clinical and laboratory evidence. Mucocutaneous lesions and chorioretinitis are important clinical findings in the presence of predisposing illness and iatrogenic factors. Repeatedly positive blood cultures for Candida in the absence of an indwelling intravenous line and Candida colony counts of 10 000/ml or greater in urine freshly obtained by catheter in the absence of an indwelling Foley catheter are very significant. Similarly significant is recovery of Candida from closed spaces (pleural, peritoneal, joint or subarachnoid). The agar gel diffusion test for Candida antibodies has a sensitivity and specificity of 85% or greater and can confirm the diagnosis in otherwise doubtful cases. The various antibody tests for Candida are not suitable for random screening because of the low prevalence of visceral or systemic candidosis in the general population.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dubois P. J., Myerowitz R. L., Allen C. M. Pathoradiologic correlation of pulmonary candidiasis in immunosuppressed patients. Cancer. 1977 Sep;40(3):1026–1036. doi: 10.1002/1097-0142(197709)40:3<1026::aid-cncr2820400310>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  2. Fishman L. S., Griffin J. R., Sapico F. L., Hecht R. Hematogenous Candida endophthalmitis--a complication of candidemia. N Engl J Med. 1972 Mar 30;286(13):675–681. doi: 10.1056/NEJM197203302861301. [DOI] [PubMed] [Google Scholar]
  3. Goldberg P. K., Kozinn P. J., Wise G. J., Nouri N., Brooks R. B. Incidence and significance of candiduria. JAMA. 1979 Feb 9;241(6):582–584. [PubMed] [Google Scholar]
  4. HUTER R. V., COLLINS H. S. The occurrence of opportunistic fungus infections in a cancer hospital. Lab Invest. 1962 Nov;11:1035–1045. [PubMed] [Google Scholar]
  5. Holder I. A., Kozinn P. J., Law E. J. Evaluation of candida precipitin and agglutinin tests for the diagnosis of systemic candidiasis in burn patients. J Clin Microbiol. 1977 Sep;6(3):219–223. doi: 10.1128/jcm.6.3.219-223.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hopfer R. L., Gröschel D. Detection by counterimmunoelectrophoresis of anti-Candida precipitins in sera from cancer patients. Am J Clin Pathol. 1979 Aug;72(2):215–218. doi: 10.1093/ajcp/72.2.215. [DOI] [PubMed] [Google Scholar]
  7. KASS E. H. Asymptomatic infections of the urinary tract. Trans Assoc Am Physicians. 1956;69:56–64. [PubMed] [Google Scholar]
  8. KOZINN P. J., TASCHDJIAN C. L. Enteric candidiasis. Diagnosis and clinical considerations. Pediatrics. 1962 Jul;30:71–85. [PubMed] [Google Scholar]
  9. Kodsi B. E., Wickremesinghe C., Kozinn P. J., Iswara K., Goldberg P. K. Candida esophagitis: a prospective study of 27 cases. Gastroenterology. 1976 Nov;71(5):715–719. [PubMed] [Google Scholar]
  10. Kozinin P. J., Taschdjian C. L., Goldberg P. K., Wise G. J., Toni E. F., Seelig M. S. Advances in the diagnosis of renal candidiasis. J Urol. 1978 Feb;119(2):184–187. doi: 10.1016/s0022-5347(17)57429-7. [DOI] [PubMed] [Google Scholar]
  11. Kozinn P. J., Taschdjian C. L., Goldberg P. K., Protzmann W. P., MacKenzie D. W., Remington J. S., Anderson S., Seelig M. S. Efficiency of serologic tests in the diagnosis of systemic candidiasis. Am J Clin Pathol. 1978 Dec;70(6):893–898. doi: 10.1093/ajcp/70.6.893. [DOI] [PubMed] [Google Scholar]
  12. Merz W. G., Evans G. L., Shadomy S., Anderson S., Kaufman L., Kozinn P. J., Mackenzie D. W., Protzman W. P., Remington J. S. Laboratory evaluation of serological tests for systemic candidiasis: a cooperative study. J Clin Microbiol. 1977 Jun;5(6):596–603. doi: 10.1128/jcm.5.6.596-603.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mohtashemi H., Davidson F. Z. Candidiasis and gastric ulcer. Am J Dig Dis. 1973 Oct;18(10):915–919. doi: 10.1007/BF01073345. [DOI] [PubMed] [Google Scholar]
  14. Murray I. G., Buckley H. R., Turner G. C. Serological evidence of Candida infection after open-heart surgery. J Med Microbiol. 1969 Nov 4;2(4):463–469. doi: 10.1099/00222615-2-4-463. [DOI] [PubMed] [Google Scholar]
  15. Seelig M. S., Kozinin P. J., Goldberg P., Berger A. R. Fungal endocarditis: patients at risk and their treatment. Postgrad Med J. 1979 Sep;55(647):632–641. doi: 10.1136/pgmj.55.647.632. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Seelig M. S., Speth C. P., Kozinn P. J., Taschdjian C. L., Toni E. F., Goldberg P. Patterns of Candida endocarditis following cardiac surgery: Importance of early diagnosis and therapy (an analysis of 91 cases). Prog Cardiovasc Dis. 1974 Sep-Oct;17(2):125–160. doi: 10.1016/0033-0620(74)90027-9. [DOI] [PubMed] [Google Scholar]
  17. Taschdjian C. L., Kozinn P. J., Fink H., Cuesta M. B., Caroline L., Kantrowitz A. B. Post mortem studies of systemic candidiasis: I. Diagnostic validity of precipitin reaction and probable origin of sensitization to cytoplasmic candidal antigens. Sabouraudia. 1969 Jun;7(2):110–117. [PubMed] [Google Scholar]
  18. Weiner M. H., Yount W. J. Mannan antigenemia in the diagnosis of invasive Candida infections. J Clin Invest. 1976 Nov;58(5):1045–1053. doi: 10.1172/JCI108555. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Young R. C., Bennett J. E., Geelhoed G. W., Levine A. S. Fungemia with compromised host resistance. A study of 70 cases. Ann Intern Med. 1974 May;80(5):605–612. doi: 10.7326/0003-4819-80-5-605. [DOI] [PubMed] [Google Scholar]

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