Abstract
Twelve cases of methanol poisoning are reviewed. The clinical presentation and biochemical features are described and the results of treatment with alkali, ethanol and dialysis reported. The outcome of methanol poisoning appears to be related more to the interval between the time of ingestion and the start of therapy and to the degree of acidosis than to the initial serum methanol level. Therefore, early and aggressive treatment with bicarbonate and ethanol and subsequent institution of hemodialysis are strongly recommended whenever methanol can be detected in the blood, especially when metabolic acidosis of the anion-gap type is present, when mental or visual disturbances are present, or when more than 30 ml of absolute methanol has been consumed.
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Selected References
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- AUSTIN W. H., LAPE C. P., BURNHAM H. N. Treatment of methanol intoxication by hemodialysis. N Engl J Med. 1961 Aug 17;265:334–334. doi: 10.1056/NEJM196108172650709. [DOI] [PubMed] [Google Scholar]
 - BENNETT I. L., Jr, CARY F. H., MITCHELL G. L., Jr, COOPER M. N. Acute methyl alcohol poisoning: a review based on experiences in an outbreak of 323 cases. Medicine (Baltimore) 1953 Dec;32(4):431–463. doi: 10.1097/00005792-195312000-00002. [DOI] [PubMed] [Google Scholar]
 - ERLANSON P., FRITZ H., HAGSTAM K. E., LILJENBERG B., TRYDING N., VOIGT G. SEVERE METHANOL INTOXICATION. Acta Med Scand. 1965 Apr;177:393–408. [PubMed] [Google Scholar]
 - Gonda A., Gault H., Churchill D., Hollomby D. Hemodialysis for methanol intoxication. Am J Med. 1978 May;64(5):749–758. doi: 10.1016/0002-9343(78)90513-2. [DOI] [PubMed] [Google Scholar]
 - MARC-AURELE J., SCHREINER G. E. The dialysance of ethanol and methanol: a proposed method for the treatment of massive intoxication by ethyl or methyl alcohol. J Clin Invest. 1960 May;39:802–807. doi: 10.1172/JCI104098. [DOI] [PMC free article] [PubMed] [Google Scholar]
 - McCoy H. G., Cipolle R. J., Ehlers S. M., Sawchuk R. J., Zaske D. E. Severe methanol poisoning. Application of a pharmacokinetic model for ethanol therapy and hemodialysis. Am J Med. 1979 Nov;67(5):804–807. doi: 10.1016/0002-9343(79)90738-1. [DOI] [PubMed] [Google Scholar]
 - McMartin K. E., Ambre J. J., Tephly T. R. Methanol poisoning in human subjects. Role for formic acid accumulation in the metabolic acidosis. Am J Med. 1980 Mar;68(3):414–418. doi: 10.1016/0002-9343(80)90113-8. [DOI] [PubMed] [Google Scholar]
 - Peterson C. D., Collins A. J., Himes J. M., Bullock M. L., Keane W. F. Ethylene glycol poisoning: pharmacokinetics during therapy with ethanol and hemodialysis. N Engl J Med. 1981 Jan 1;304(1):21–23. doi: 10.1056/NEJM198101013040105. [DOI] [PubMed] [Google Scholar]
 - STINEBAUGH B. J. The use of peritoneal dialysis in acute methyl alcohol poisoning. Arch Intern Med. 1960 Apr;105:613–617. doi: 10.1001/archinte.1960.00270160111014. [DOI] [PubMed] [Google Scholar]
 - Schreiner G. E. Dialysis of poisons and drugs--annual review. Trans Am Soc Artif Intern Organs. 1970;16:544–568. [PubMed] [Google Scholar]
 - Vestal R. E., McGuire E. A., Tobin J. D., Andres R., Norris A. H., Mezey E. Aging and ethanol metabolism. Clin Pharmacol Ther. 1977 Mar;21(3):343–354. doi: 10.1002/cpt1977213343. [DOI] [PubMed] [Google Scholar]
 - Wilkinson P. K., Sedman A. J., Sakmar E., Earhart R. H., Weidler D. J., Wagner J. G. Blood ethanol concentrations during and following constant-rate intravenous infusion of alcohol. Clin Pharmacol Ther. 1976 Feb;19(2):213–223. doi: 10.1002/cpt1976192213. [DOI] [PubMed] [Google Scholar]
 
