Abstract
In a group of patients with monoclonal gammopathies a decrease in the serum anion gap was seen with increasing serum concentrations of monoclonal IgG and IgM but not monoclonal IgA. This was probably related to the fact that IgG and IgM are cationic but IgA is a anionic at a physiologic pH. The serum sodium level decreased by 0.7 mmol/l for every increase of 1 g/dl in the serum level of the monoclonal immunoglobulin, likely because of the volume displacement effect of the monoclonal protein.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Frohlich J., Adam W., Golbey M. J., Bernstein M. Decreased anion gap associated with monoclonal and pseudomonoclonal gammopathy. Can Med Assoc J. 1976 Feb 7;114(3):231–232. [PMC free article] [PubMed] [Google Scholar]
- Murray T., Long W., Narins R. G. Multiple myeloma and the anion gap. N Engl J Med. 1975 Mar 13;292(11):574–575. doi: 10.1056/NEJM197503132921107. [DOI] [PubMed] [Google Scholar]
- Schnur M. J., Appel G. B., Karp G., Osserman E. P. The anion gap in asymptomatic plasma cell dyscrasias. Ann Intern Med. 1977 Mar;86(3):304–305. doi: 10.7326/0003-4819-86-3-304. [DOI] [PubMed] [Google Scholar]
- TARAIL R., BUCHWALD K. W., HOLLAND J. F., SELAWRY O. S. Misleading reductions of serum sodium and chloride associated with hyperproteinemia in patients with multiple myeloma. Proc Soc Exp Biol Med. 1962 May;110:145–148. doi: 10.3181/00379727-110-27449. [DOI] [PubMed] [Google Scholar]
- Vader H. L., Vink C. L. The influence of viscosity on dilution methods. Its problems in the determination of serum sodium. Clin Chim Acta. 1975 Dec 15;65(3):379–388. doi: 10.1016/0009-8981(75)90264-8. [DOI] [PubMed] [Google Scholar]