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. 1994 May;62(5):2104–2107. doi: 10.1128/iai.62.5.2104-2107.1994

Identification of two functional forms of immunoglobulin G3-binding protein expressed by group A streptococci.

T D Pack 1, R A Otten 1, R H Raeder 1, M D Boyle 1
PMCID: PMC186474  PMID: 8168976

Abstract

Analysis of group A streptococcal immunoglobulin G (IgG)-binding protein reactivity with different human IgG3-myeloma proteins provided evidence for at least two functional forms of these molecules. Representative IgG3-binding molecules were isolated, biotinylated, and used as tracers in competitive binding assays. Cross-inhibition studies demonstrated the existence of two distinct patterns of IgG3-binding activity. Proteins of one form could be inhibited from binding to an IgG3-myeloma protein by streptococcal protein G while binding of the second form was not inhibited. These studies further underscore the extent of heterogeneity among immunoglobulin-binding proteins expressed by group A streptococci.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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