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. 1994 May;62(5):2115–2118. doi: 10.1128/iai.62.5.2115-2118.1994

Mouse sialoadhesin is not responsible for Candida albicans yeast cell binding to splenic marginal zone macrophages.

Y Han 1, S Kelm 1, M H Riesselman 1, P R Crocker 1, J E Cutler 1
PMCID: PMC186477  PMID: 8168979

Abstract

Candida albicans hydrophilic yeast cells specifically adhere to mouse macrophages in the splenic marginal zone and in lymph node subcapsular and medullary sinuses. These macrophages express sialoadhesin that binds erythrocytes, but binding of yeast cells is not mediated by sialoadhesin because (i) erythrocytes did not block yeast cell binding, (ii) yeast cell adherence was unaffected by sialoadhesin-specific monoclonal antibodies, (iii) the purified sialoadhesin did not bind to yeast cells, and (iv) an Fc-sialoadhesin chimera immobilized on plastic did not bind yeast cells. These data give further support for a unique macrophage adhesion system that binds C. albicans.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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