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. 1994 May;62(5):2119–2121. doi: 10.1128/iai.62.5.2119-2121.1994

Differential expression of the cytotoxic and hemolytic activities of the ApxIIA toxin from Actinobacillus pleuropneumoniae.

A H Tu 1, C Hausler 1, R Young 1, D K Struck 1
PMCID: PMC186478  PMID: 8168980

Abstract

The ApxIIA protein secreted from Actinobacillus pleuropneumoniae is both hemolytic and cytotoxic. However, when the cloned apxII operon is expressed in Escherichia coli, two forms of the ApxIIA protein can be recovered. Toxin which remains intracellular has hemolytic and cytotoxic activities, while toxin that is secreted is cytotoxic with little or no hemolytic activity. This indicates that the cytotoxicity of ApxIIA is independent of its hemolytic activity.

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Selected References

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