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. 1994 May;62(5):2135–2137. doi: 10.1128/iai.62.5.2135-2137.1994

Inhibition of nitric oxide synthesis leads to reduced parasitemia in murine Trypanosoma brucei infection.

J Sternberg 1, N Mabbott 1, I Sutherland 1, F Y Liew 1
PMCID: PMC186483  PMID: 8168985

Abstract

In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.

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Selected References

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