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. 2002 May;50(Suppl 3):iii15–iii18. doi: 10.1136/gut.50.suppl_3.iii15

Novel targets for the control of secretory diarrhoea

M Farthing
PMCID: PMC1867674  PMID: 11953327

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Selected References

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  1. Abbas Z., Moid I., Khan A. H., Jafri S. M., Shah S. H., Abid S., Hamid S. Efficacy of octreotide in diarrhoea due to Vibrio cholerae: a randomized, controlled trial. Ann Trop Med Parasitol. 1996 Oct;90(5):507–513. doi: 10.1080/00034983.1996.11813076. [DOI] [PubMed] [Google Scholar]
  2. Bearcroft C. P., André E. A., Farthing M. J. In vivo effects of the 5-HT3 antagonist alosetron on basal and cholera toxin-induced secretion in the human jejunum: a segmental perfusion study. Aliment Pharmacol Ther. 1997 Dec;11(6):1109–1114. doi: 10.1046/j.1365-2036.1997.d01-1389.x. [DOI] [PubMed] [Google Scholar]
  3. Bearcroft C. P., Perrett D., Farthing M. J. 5-hydroxytryptamine release into human jejunum by cholera toxin. Gut. 1996 Oct;39(4):528–531. doi: 10.1136/gut.39.4.528. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Beubler E., Horina G. 5-HT2 and 5-HT3 receptor subtypes mediate cholera toxin-induced intestinal fluid secretion in the rat. Gastroenterology. 1990 Jul;99(1):83–89. doi: 10.1016/0016-5085(90)91233-v. [DOI] [PubMed] [Google Scholar]
  5. Beubler E., Kollar G., Saria A., Bukhave K., Rask-Madsen J. Involvement of 5-hydroxytryptamine, prostaglandin E2, and cyclic adenosine monophosphate in cholera toxin-induced fluid secretion in the small intestine of the rat in vivo. Gastroenterology. 1989 Feb;96(2 Pt 1):368–376. doi: 10.1016/0016-5085(89)91560-6. [DOI] [PubMed] [Google Scholar]
  6. Buchheit K. H. Inhibition of cholera toxin-induced intestinal secretion by the 5-HT3 receptor antagonist ICS 205-930. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jun;339(6):704–705. doi: 10.1007/BF00168665. [DOI] [PubMed] [Google Scholar]
  7. Cassuto J., Fahrenkrug J., Jodal M., Tuttle R., Lundgren O. Release of vasoactive intestinal polypeptide from the cat small intestine exposed to cholera toxin. Gut. 1981 Nov;22(11):958–963. doi: 10.1136/gut.22.11.958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cézard J. P., Duhamel J. F., Meyer M., Pharaon I., Bellaiche M., Maurage C., Ginies J. L., Vaillant J. M., Girardet J. P., Lamireau T. Efficacy and tolerability of racecadotril in acute diarrhea in children. Gastroenterology. 2001 Mar;120(4):799–805. doi: 10.1053/gast.2001.22544. [DOI] [PubMed] [Google Scholar]
  9. Eherer A. J., Hinterleitner T. A., Petritsch W., Holzer-Petsche U., Beubler E., Krejs G. J. Effect of 5-hydroxytryptamine antagonists on cholera toxin-induced secretion in the human jejunum. Eur J Clin Invest. 1994 Oct;24(10):664–668. doi: 10.1111/j.1365-2362.1994.tb01058.x. [DOI] [PubMed] [Google Scholar]
  10. Eklund S., Jodal M., Lundgren O. The enteric nervous system participates in the secretory response to the heat stable enterotoxins of Escherichia coli in rats and cats. Neuroscience. 1985 Feb;14(2):673–681. doi: 10.1016/0306-4522(85)90318-5. [DOI] [PubMed] [Google Scholar]
  11. Farthing M. J. Introduction. Enkephalinase inhibition: a rational approach to antisecretory therapy for acute diarrhoea. Aliment Pharmacol Ther. 1999 Dec;13 (Suppl 6):1–2. [PubMed] [Google Scholar]
  12. Farthing M. J. The role of somatostatin analogues in the treatment of refractory diarrhoea. Digestion. 1996;57 (Suppl 1):107–113. doi: 10.1159/000201412. [DOI] [PubMed] [Google Scholar]
  13. Field M., Rao M. C., Chang E. B. Intestinal electrolyte transport and diarrheal disease (2) N Engl J Med. 1989 Sep 28;321(13):879–883. doi: 10.1056/NEJM198909283211307. [DOI] [PubMed] [Google Scholar]
  14. Fried M. Octreotide in the treatment of refractory diarrhea. Digestion. 1999;60 (Suppl 2):42–46. doi: 10.1159/000051479. [DOI] [PubMed] [Google Scholar]
  15. Hamza H., Ben Khalifa H., Baumer P., Berard H., Lecomte J. M. Racecadotril versus placebo in the treatment of acute diarrhoea in adults. Aliment Pharmacol Ther. 1999 Dec;13 (Suppl 6):15–19. doi: 10.1046/j.1365-2036.1999.00002.x-i1. [DOI] [PubMed] [Google Scholar]
  16. Hubel K. A. Intestinal nerves and ion transport: stimuli, reflexes, and responses. Am J Physiol. 1985 Mar;248(3 Pt 1):G261–G271. doi: 10.1152/ajpgi.1985.248.3.G261. [DOI] [PubMed] [Google Scholar]
  17. Jodal M. Neuronal influence on intestinal transport. J Intern Med Suppl. 1990;732:125–132. doi: 10.1111/j.1365-2796.1990.tb01484.x. [DOI] [PubMed] [Google Scholar]
  18. Mourad F. H., Nassar C. F. Effect of vasoactive intestinal polypeptide (VIP) antagonism on rat jejunal fluid and electrolyte secretion induced by cholera and Escherichia coli enterotoxins. Gut. 2000 Sep;47(3):382–386. doi: 10.1136/gut.47.3.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Mourad F. H., O'Donnell L. J., Dias J. A., Ogutu E., Andre E. A., Turvill J. L., Farthing M. J. Role of 5-hydroxytryptamine type 3 receptors in rat intestinal fluid and electrolyte secretion induced by cholera and Escherichia coli enterotoxins. Gut. 1995 Sep;37(3):340–345. doi: 10.1136/gut.37.3.340. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Munck L. K., Mertz-Nielsen A., Westh H., Bukhave K., Beubler E., Rask-Madsen J. Prostaglandin E2 is a mediator of 5-hydroxytryptamine induced water and electrolyte secretion in the human jejunum. Gut. 1988 Oct;29(10):1337–1341. doi: 10.1136/gut.29.10.1337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Primi M. P., Bueno L., Baumer P., Berard H., Lecomte J. M. Racecadotril demonstrates intestinal antisecretory activity in vivo. Aliment Pharmacol Ther. 1999 Dec;13 (Suppl 6):3–7. doi: 10.1046/j.1365-2036.13.s6.3.x. [DOI] [PubMed] [Google Scholar]
  22. Salazar-Lindo E., Santisteban-Ponce J., Chea-Woo E., Gutierrez M. Racecadotril in the treatment of acute watery diarrhea in children. N Engl J Med. 2000 Aug 17;343(7):463–467. doi: 10.1056/NEJM200008173430703. [DOI] [PubMed] [Google Scholar]
  23. Turck D., Berard H., Fretault N., Lecomte J. M. Comparison of racecadotril and loperamide in children with acute diarrhoea. Aliment Pharmacol Ther. 1999 Dec;13 (Suppl 6):27–32. doi: 10.1046/j.1365-2036.1999.00004.x-i1. [DOI] [PubMed] [Google Scholar]
  24. Turvill J. L., Connor P., Farthing M. J. Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum. Gastroenterology. 2000 Oct;119(4):1037–1044. doi: 10.1053/gast.2000.18147. [DOI] [PubMed] [Google Scholar]
  25. Turvill J. L., Connor P., Farthing M. J. The inhibition of cholera toxin-induced 5-HT release by the 5-HT(3) receptor antagonist, granisetron, in the rat. Br J Pharmacol. 2000 Jul;130(5):1031–1036. doi: 10.1038/sj.bjp.0703414. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Turvill J. L., Farthing M. J. Effect of granisetron on cholera toxin-induced enteric secretion. Lancet. 1997 May 3;349(9061):1293–1293. doi: 10.1016/S0140-6736(97)24018-3. [DOI] [PubMed] [Google Scholar]
  27. Turvill J. L., Kasapidis P., Farthing M. J. The sigma ligand, igmesine, inhibits cholera toxin and Escherichia coli enterotoxin induced jejunal secretion in the rat. Gut. 1999 Oct;45(4):564–569. doi: 10.1136/gut.45.4.564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Turvill J., Farthing M. Enkephalins and enkephalinase inhibitors in intestinal fluid and electrolyte transport. Eur J Gastroenterol Hepatol. 1997 Sep;9(9):877–880. doi: 10.1097/00042737-199709000-00010. [DOI] [PubMed] [Google Scholar]

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