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. 2002 May;50(Suppl 4):iv58–iv62. doi: 10.1136/gut.50.suppl_4.iv58

H2 receptor antagonists and prokinetics in dyspepsia: a critical review

P Bytzer
PMCID: PMC1867686  PMID: 11953351

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Selected References

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  1. Agréus L., Svärdsudd K., Nyrén O., Tibblin G. Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. Gastroenterology. 1995 Sep;109(3):671–680. doi: 10.1016/0016-5085(95)90373-9. [DOI] [PubMed] [Google Scholar]
  2. Agréus L., Svärdsudd K., Nyrén O., Tibblin G. The epidemiology of abdominal symptoms: prevalence and demographic characteristics in a Swedish adult population. A report from the Abdominal Symptom Study. Scand J Gastroenterol. 1994 Feb;29(2):102–109. doi: 10.3109/00365529409090447. [DOI] [PubMed] [Google Scholar]
  3. Bendtsen F., Danø P., Guldhammer B., Remvig L., Krogsøe O. Cimetidinbehandling af røntgennegativ dyspepsi. Ugeskr Laeger. 1983 Oct 3;145(40):3090–3093. [PubMed] [Google Scholar]
  4. Champion M. C., MacCannell K. L., Thomson A. B., Tanton R., Eberhard S., Sullivan S. N., Archambault A. A double-blind randomized study of cisapride in the treatment of nonulcer dyspepsia. The Canadian Cisapride Nud Study Group. Can J Gastroenterol. 1997 Mar;11(2):127–134. doi: 10.1155/1997/314839. [DOI] [PubMed] [Google Scholar]
  5. Chung J. M. Cisapride in chronic dyspepsia: results of a double-blind, placebo-controlled trial. Scand J Gastroenterol Suppl. 1993;195:11–14. doi: 10.3109/00365529309098323. [DOI] [PubMed] [Google Scholar]
  6. Corinaldesi R., Stanghellini V., Raiti C., Rea E., Salgemini R., Barbara L. Effect of chronic administration of cisapride on gastric emptying of a solid meal and on dyspeptic symptoms in patients with idiopathic gastroparesis. Gut. 1987 Mar;28(3):300–305. doi: 10.1136/gut.28.3.300. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Davis R. H., Clench M. H., Mathias J. R. Effects of domperidone in patients with chronic unexplained upper gastrointestinal symptoms: a double-blind, placebo-controlled study. Dig Dis Sci. 1988 Dec;33(12):1505–1511. doi: 10.1007/BF01535938. [DOI] [PubMed] [Google Scholar]
  8. De Nutte N., Van Ganse W., Witterhulghe M., Defrance P. Relief of epigastric pain in nonulcer dyspepsia: controlled trial of the promotility drug cisapride. Clin Ther. 1989;11(1):62–68. [PubMed] [Google Scholar]
  9. Deruyttere M., Lepoutre L., Heylen H., Samain H., Pennoit H. Cisapride in the management of chronic functional dyspepsia: a multicenter, double-blind, placebo-controlled study. Clin Ther. 1987;10(1):44–51. [PubMed] [Google Scholar]
  10. Dobrilla G., Comberlato M., Steele A., Vallaperta P. Drug treatment of functional dyspepsia. A meta-analysis of randomized controlled clinical trials. J Clin Gastroenterol. 1989 Apr;11(2):169–177. doi: 10.1097/00004836-198904000-00011. [DOI] [PubMed] [Google Scholar]
  11. Farup P. G., Hovde O., Breder O. Are frequent short gastro-oesophageal reflux episodes the cause of symptoms in patients with non-ulcer dyspepsia responding to treatment with ranitidine? Scand J Gastroenterol. 1995 Sep;30(9):829–832. doi: 10.3109/00365529509101587. [DOI] [PubMed] [Google Scholar]
  12. Farup P. G., Larsen S., Ulshagen K., Osnes M. Ranitidine for non-ulcer dyspepsia. A clinical study of the symptomatic effect of ranitidine and a classification and characterization of the responders to treatment. Scand J Gastroenterol. 1991 Nov;26(11):1209–1216. doi: 10.3109/00365529108998616. [DOI] [PubMed] [Google Scholar]
  13. Finney J. S., Kinnersley N., Hughes M., O'Bryan-Tear C. G., Lothian J. Meta-analysis of antisecretory and gastrokinetic compounds in functional dyspepsia. J Clin Gastroenterol. 1998 Jun;26(4):312–320. doi: 10.1097/00004836-199806000-00022. [DOI] [PubMed] [Google Scholar]
  14. Frazzoni M., Lonardo A., Grisendi A., Della Casa G., Pulvirenti M., Ferrari A. M., Di Gregorio C., Melini L. Are routine duodenal and antral biopsies useful in the management of "functional" dyspepsia? A diagnostic and therapeutic study. J Clin Gastroenterol. 1993 Sep;17(2):101–108. doi: 10.1097/00004836-199309000-00004. [DOI] [PubMed] [Google Scholar]
  15. Gotthard R., Bodemar G., Brodin U., Jönsson K. A. Treatment with cimetidine, antacid, or placebo in patients with dyspepsia of unknown origin. Scand J Gastroenterol. 1988 Jan;23(1):7–18. doi: 10.3109/00365528809093840. [DOI] [PubMed] [Google Scholar]
  16. Hadi S. Clinical investigation of ranitidine in patients with gastritis. Clin Ther. 1989 Sep-Oct;11(5):590–594. [PubMed] [Google Scholar]
  17. Hansen J. M., Bytzer P., Schaffalitzky de Muckadell O. B. Placebo-controlled trial of cisapride and nizatidine in unselected patients with functional dyspepsia. Am J Gastroenterol. 1998 Mar;93(3):368–374. doi: 10.1111/j.1572-0241.1998.00368.x. [DOI] [PubMed] [Google Scholar]
  18. Hausken T., Berstad A. Cisapride treatment of patients with non-ulcer dyspepsia and erosive prepyloric changes. A double-blind, placebo-controlled trial. Scand J Gastroenterol. 1992;27(3):213–217. doi: 10.3109/00365529208999951. [DOI] [PubMed] [Google Scholar]
  19. Jian R., Ducrot F., Ruskone A., Chaussade S., Rambaud J. C., Modigliani R., Rain J. D., Bernier J. J. Symptomatic, radionuclide and therapeutic assessment of chronic idiopathic dyspepsia. A double-blind placebo-controlled evaluation of cisapride. Dig Dis Sci. 1989 May;34(5):657–664. doi: 10.1007/BF01540334. [DOI] [PubMed] [Google Scholar]
  20. Johannessen T., Fjøsne U., Kleveland P. M., Halvorsen T., Kristensen P., Løge I., Hafstad P. E., Sandbakken P., Petersen H. Cimetidine responders in non-ulcer dyspepsia. Scand J Gastroenterol. 1988 Apr;23(3):327–336. doi: 10.3109/00365528809093874. [DOI] [PubMed] [Google Scholar]
  21. Johannessen T., Kristensen P., Petersen H., Fosstvedt D., Løge I., Kleveland P. M., Dybdahl J. The symptomatic effect of 1-day treatment periods with cimetidine in dyspepsia. Combined results from randomized, controlled, single-subject trials. Scand J Gastroenterol. 1991 Sep;26(9):974–980. doi: 10.3109/00365529108996251. [DOI] [PubMed] [Google Scholar]
  22. Johannessen T., Petersen H., Kristensen P., Fosstvedt D., Kleveland P. M., Dybdahl J., Løge I. Cimetidine on-demand in dyspepsia. Experience with randomized controlled single-subject trials. Scand J Gastroenterol. 1992;27(3):189–195. doi: 10.3109/00365529208999947. [DOI] [PubMed] [Google Scholar]
  23. Kelbaek H., Linde J., Eriksen J., Mungaard S., Moesgaard F., Bonnevie O. Controlled clinical trial of treatment with cimetidine for non-ulcer dyspepsia. Acta Med Scand. 1985;217(3):281–287. doi: 10.1111/j.0954-6820.1985.tb02696.x. [DOI] [PubMed] [Google Scholar]
  24. Kellow J. E., Cowan H., Shuter B., Riley J. W., Lunzer M. R., Eckstein R. P., Höschl R., Lam S. K. Efficacy of cisapride therapy in functional dyspepsia. Aliment Pharmacol Ther. 1995 Apr;9(2):153–160. doi: 10.1111/j.1365-2036.1995.tb00364.x. [DOI] [PubMed] [Google Scholar]
  25. Kleveland P. M., Larsen S., Sandvik L., Kristensen P., Johannessen T., Hafstad P. E., Sandbakken P., Løge I., Fjøsne U., Petersen H. The effect of cimetidine in non-ulcer dyspepsia. Experience with a multi-cross-over model. Scand J Gastroenterol. 1985 Jan;20(1):19–24. doi: 10.3109/00365528509089627. [DOI] [PubMed] [Google Scholar]
  26. Lance P., Wastell C., Schiller K. F. A controlled trial of cimetidine for the treatment of nonulcer dyspepsia. J Clin Gastroenterol. 1986 Aug;8(4):414–418. doi: 10.1097/00004836-198608000-00006. [DOI] [PubMed] [Google Scholar]
  27. Mackinnon M., Willing R. L., Whitehead R. Cimetidine in the management of symptomatic patients with duodenitis: a double-blind controlled trial. Dig Dis Sci. 1982 Mar;27(3):217–219. doi: 10.1007/BF01296918. [DOI] [PubMed] [Google Scholar]
  28. Müller P., Hotz J., Franz E., Simon B. Ranitidine in the treatment of non-ulcer dyspepsia. A placebo-controlled study in the Federal Republic of Germany. Arzneimittelforschung. 1994 Oct;44(10):1130–1132. [PubMed] [Google Scholar]
  29. Nesland A. A., Berstad A. Effect of cimetidine in patients with non-ulcer dyspepsia and erosive prepyloric changes. Scand J Gastroenterol. 1985 Jun;20(5):629–635. doi: 10.3109/00365528509089708. [DOI] [PubMed] [Google Scholar]
  30. Nyrén O., Adami H. O., Bates S., Bergström R., Gustavsson S., Löf L., Nyberg A. Absence of therapeutic benefit from antacids or cimetidine in non-ulcer dyspepsia. N Engl J Med. 1986 Feb 6;314(6):339–343. doi: 10.1056/NEJM198602063140603. [DOI] [PubMed] [Google Scholar]
  31. Nyrén O., Gustavsson S., Adami H. O., Löf L. Methodological aspects of clinical trials in non-ulcer dyspepsia with special reference to selectional factors. Scand J Gastroenterol Suppl. 1985;109:159–162. doi: 10.3109/00365528509103952. [DOI] [PubMed] [Google Scholar]
  32. Olubuyide I. O., Ayoola E. A., Okubanjo A. O., Atoba M. A. Non-ulcer dyspepsia in Nigerians clinical and therapeutic results. Scand J Gastroenterol Suppl. 1986;124:83–87. doi: 10.3109/00365528609093787. [DOI] [PubMed] [Google Scholar]
  33. Rösch W. Cisapride in non-ulcer dyspepsia. Results of a placebo-controlled trial. Scand J Gastroenterol. 1987 Mar;22(2):161–164. doi: 10.3109/00365528708991874. [DOI] [PubMed] [Google Scholar]
  34. Saunders J. H., Oliver R. J., Higson D. L. Dyspepsia: incidence of a non-ulcer disease in a controlled trial of ranitidine in general practice. Br Med J (Clin Res Ed) 1986 Mar 8;292(6521):665–668. doi: 10.1136/bmj.292.6521.665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Singal A. K., Kumar A., Broor S. L. Cimetidine in the treatment of non-ulcer dyspepsia: results of a randomized double-blind, placebo-controlled study. Curr Med Res Opin. 1989;11(6):390–397. doi: 10.1185/03007998909110140. [DOI] [PubMed] [Google Scholar]
  36. Talley N. J. Drug treatment of functional dyspepsia. Scand J Gastroenterol Suppl. 1991;182:47–60. [PubMed] [Google Scholar]
  37. Talley N. J., McNeil D., Hayden A., Piper D. W. Randomized, double-blind, placebo-controlled crossover trial of cimetidine and pirenzepine in nonulcer dyspepsia. Gastroenterology. 1986 Jul;91(1):149–156. doi: 10.1016/0016-5085(86)90451-8. [DOI] [PubMed] [Google Scholar]
  38. Tatsuta M., Iishi H., Nakaizumi A., Okuda S. Effect of treatment with cisapride alone or in combination with domperidone on gastric emptying and gastrointestinal symptoms in dyspeptic patients. Aliment Pharmacol Ther. 1992 Apr;6(2):221–228. doi: 10.1111/j.1365-2036.1992.tb00265.x. [DOI] [PubMed] [Google Scholar]
  39. Van Outryve M., De Nutte N., Van Eeghem P., Gooris J. P. Efficacy of cisapride in functional dyspepsia resistant to domperidone or metoclopramide: a double-blind, placebo-controlled study. Scand J Gastroenterol Suppl. 1993;195:47–53. doi: 10.3109/00365529309098328. [DOI] [PubMed] [Google Scholar]
  40. Veldhuyzen van Zanten S. J., Cleary C., Talley N. J., Peterson T. C., Nyrén O., Bradley L. A., Verlinden M., Tytgat G. N. Drug treatment of functional dyspepsia: a systematic analysis of trial methodology with recommendations for design of future trials. Am J Gastroenterol. 1996 Apr;91(4):660–673. [PubMed] [Google Scholar]
  41. Veldhuyzen van Zanten S. J., Jones M. J., Verlinden M., Talley N. J. Efficacy of cisapride and domperidone in functional (nonulcer) dyspepsia: a meta-analysis. Am J Gastroenterol. 2001 Mar;96(3):689–696. doi: 10.1111/j.1572-0241.2001.03521.x. [DOI] [PubMed] [Google Scholar]
  42. Veldhuyzen van Zanten S. J., Talley N. J., Bytzer P., Klein K. B., Whorwell P. J., Zinsmeister A. R. Design of treatment trials for functional gastrointestinal disorders. Gut. 1999 Sep;45 (Suppl 2):II69–II77. doi: 10.1136/gut.45.2008.ii69. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Wood S. F., Penney S. C., Cochran K. M. Cisapride in functional dyspepsia: a double-blind, placebo-controlled randomized trial in general practice patients. Scand J Gastroenterol Suppl. 1993;195:5–10. doi: 10.3109/00365529309098322. [DOI] [PubMed] [Google Scholar]
  44. Yeoh K. G., Kang J. Y., Tay H. H., Gwee K. A., Tan C. C., Wee A., Teh M., Choo H. F., Chintana-Wilde W. Effect of cisapride on functional dyspepsia in patients with and without histological gastritis: a double-blind placebo-controlled trial. J Gastroenterol Hepatol. 1997 Jan;12(1):13–18. doi: 10.1111/j.1440-1746.1997.tb00338.x. [DOI] [PubMed] [Google Scholar]
  45. al-Quorain A., Larbi E. B., al-Shedoki F. A double-blind, randomized, placebo-controlled trial of cisapride in Saudi Arabs with functional dyspepsia. Scand J Gastroenterol. 1995 Jun;30(6):531–534. doi: 10.3109/00365529509089785. [DOI] [PubMed] [Google Scholar]
  46. de Groot G. H., de Both P. S. Cisapride in functional dyspepsia in general practice. A placebo-controlled, randomized, double-blind study. Aliment Pharmacol Ther. 1997 Feb;11(1):193–199. doi: 10.1046/j.1365-2036.1997.117288000.x. [DOI] [PubMed] [Google Scholar]

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