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Figure 1 .
Schematic organisation of afferent nerve pathways originating from the gastrointestinal tract.
Figure 2 .
Various distension protocols used to measure sensory thresholds in patients with irritable bowel syndrome. With the tracking technique, subjects receive multiple distensions at around the threshold level in order to track their response. The double random staircase method uses the barostat to deliver two randomly mixed scales of impulse progression so that the stimulus cannot be predicted by the subject. *Positive response.
Selected References
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- Accarino A. M., Azpiroz F., Malagelada J. R. Selective dysfunction of mechanosensitive intestinal afferents in irritable bowel syndrome. Gastroenterology. 1995 Mar;108(3):636–643. doi: 10.1016/0016-5085(95)90434-4. [DOI] [PubMed] [Google Scholar]
- Accarino A. M., Azpiroz F., Malagelada J. R. Symptomatic responses to stimulation of sensory pathways in the jejunum. Am J Physiol. 1992 Nov;263(5 Pt 1):G673–G677. doi: 10.1152/ajpgi.1992.263.5.G673. [DOI] [PubMed] [Google Scholar]
- Azpiroz F., Malagelada J. R. Perception and reflex relaxation of the stomach in response to gut distention. Gastroenterology. 1990 May;98(5 Pt 1):1193–1198. doi: 10.1016/0016-5085(90)90333-v. [DOI] [PubMed] [Google Scholar]
- Berman S., Munakata J., Naliboff B. D., Chang L., Mandelkern M., Silverman D., Kovalik E., Mayer E. A. Gender differences in regional brain response to visceral pressure in IBS patients. Eur J Pain. 2000;4(2):157–172. doi: 10.1053/eujp.2000.0167. [DOI] [PubMed] [Google Scholar]
- Besson J. M. La douleur: aspects physiopharmacologiques. C R Seances Soc Biol Fil. 1992;186(1-2):26–36. [PubMed] [Google Scholar]
- Björnsson E. S., Chey W. D., Ladabaum U., Woods M. L., Hooper F. G., Owyang C., Hasler W. L. Differential 5-HT3 mediation of human gastrocolonic response and colonic peristaltic reflex. Am J Physiol. 1998 Sep;275(3 Pt 1):G498–G505. doi: 10.1152/ajpgi.1998.275.3.G498. [DOI] [PubMed] [Google Scholar]
- Bouin M., Delvaux M., Blanc C., Lagier E., Delisle M. B., Fioramonti J., Buéno L., Frexinos J. Intrarectal injection of glycerol induces hypersensitivity to rectal distension in healthy subjects without modifying rectal compliance. Eur J Gastroenterol Hepatol. 2001 May;13(5):573–580. doi: 10.1097/00042737-200105000-00018. [DOI] [PubMed] [Google Scholar]
- Bradette M., Delvaux M., Staumont G., Fioramonti J., Bueno L., Frexinos J. Evaluation of colonic sensory thresholds in IBS patients using a barostat. Definition of optimal conditions and comparison with healthy subjects. Dig Dis Sci. 1994 Mar;39(3):449–457. doi: 10.1007/BF02088327. [DOI] [PubMed] [Google Scholar]
- Bradette M., Delvaux M., Staumont G., Fioramonti J., Bueno L., Frexinos J. Octreotide increases thresholds of colonic visceral perception in IBS patients without modifying muscle tone. Dig Dis Sci. 1994 Jun;39(6):1171–1178. doi: 10.1007/BF02093780. [DOI] [PubMed] [Google Scholar]
- Bueno L., Fioramonti J., Delvaux M., Frexinos J. Mediators and pharmacology of visceral sensitivity: from basic to clinical investigations. Gastroenterology. 1997 May;112(5):1714–1743. doi: 10.1016/s0016-5085(97)70056-8. [DOI] [PubMed] [Google Scholar]
- Bueno L., Fioramonti J., Ruckebusch Y., Frexinos J., Coulom P. Evaluation of colonic myoelectrical activity in health and functional disorders. Gut. 1980 Jun;21(6):480–485. doi: 10.1136/gut.21.6.480. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHAUDHARY N. A., TRUELOVE S. C. The irritable colon syndrome. A study of the clinical features, predisposing causes, and prognosis in 130 cases. Q J Med. 1962 Jul;31:307–322. [PubMed] [Google Scholar]
- Cervero F. Sensory innervation of the viscera: peripheral basis of visceral pain. Physiol Rev. 1994 Jan;74(1):95–138. doi: 10.1152/physrev.1994.74.1.95. [DOI] [PubMed] [Google Scholar]
- Chey W. D., Beydoun A., Roberts D. J., Hasler W. L., Owyang C. Octreotide reduces perception of rectal electrical stimulation by spinal afferent pathway inhibition. Am J Physiol. 1995 Dec;269(6 Pt 1):G821–G826. doi: 10.1152/ajpgi.1995.269.6.G821. [DOI] [PubMed] [Google Scholar]
- Collins S. M., Vallance B., Barbara G., Borgaonkar M. Putative inflammatory and immunological mechanisms in functional bowel disorders. Baillieres Best Pract Res Clin Gastroenterol. 1999 Oct;13(3):429–436. doi: 10.1053/bega.1999.0037. [DOI] [PubMed] [Google Scholar]
- Delvaux M., Louvel D., Lagier E., Scherrer B., Abitbol J. L., Frexinos J. The kappa agonist fedotozine relieves hypersensitivity to colonic distention in patients with irritable bowel syndrome. Gastroenterology. 1999 Jan;116(1):38–45. doi: 10.1016/s0016-5085(99)70226-x. [DOI] [PubMed] [Google Scholar]
- Drossman D. A., Whitehead W. E., Camilleri M. Irritable bowel syndrome: a technical review for practice guideline development. Gastroenterology. 1997 Jun;112(6):2120–2137. doi: 10.1053/gast.1997.v112.agast972120. [DOI] [PubMed] [Google Scholar]
- Farthing M. J., Lennard-jones J. E. Sensibility of the rectum to distension and the anorectal distension reflex in ulcerative colitis. Gut. 1978 Jan;19(1):64–69. doi: 10.1136/gut.19.1.64. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ford M. J., Camilleri M., Zinsmeister A. R., Hanson R. B. Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon. Gastroenterology. 1995 Dec;109(6):1772–1780. doi: 10.1016/0016-5085(95)90743-2. [DOI] [PubMed] [Google Scholar]
- Frexinos J., Bueno L., Fioramonti J. Diurnal changes in myoelectric spiking activity of the human colon. Gastroenterology. 1985 May;88(5 Pt 1):1104–1110. doi: 10.1016/s0016-5085(85)80067-6. [DOI] [PubMed] [Google Scholar]
- Frexinos J., Bueno L., Fioramonti J. Diurnal changes in myoelectric spiking activity of the human colon. Gastroenterology. 1985 May;88(5 Pt 1):1104–1110. doi: 10.1016/s0016-5085(85)80067-6. [DOI] [PubMed] [Google Scholar]
- Gwee K. A., Graham J. C., McKendrick M. W., Collins S. M., Marshall J. S., Walters S. J., Read N. W. Psychometric scores and persistence of irritable bowel after infectious diarrhoea. Lancet. 1996 Jan 20;347(8995):150–153. doi: 10.1016/s0140-6736(96)90341-4. [DOI] [PubMed] [Google Scholar]
- Harraf F., Schmulson M., Saba L., Niazi N., Fass R., Munakata J., Diehl D., Mertz H., Naliboff B., Mayer E. A. Subtypes of constipation predominant irritable bowel syndrome based on rectal perception. Gut. 1998 Sep;43(3):388–394. doi: 10.1136/gut.43.3.388. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hasler W. L., Soudah H. C., Owyang C. A somatostatin analogue inhibits afferent pathways mediating perception of rectal distention. Gastroenterology. 1993 May;104(5):1390–1397. doi: 10.1016/0016-5085(93)90347-f. [DOI] [PubMed] [Google Scholar]
- Kellow J. E., Delvaux M., Azpiroz F., Camilleri M., Quigley E. M., Thompson D. G. Principles of applied neurogastroenterology: physiology/motility-sensation. Gut. 1999 Sep;45 (Suppl 2):II17–II24. doi: 10.1136/gut.45.2008.ii17. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kellow J. E., Eckersley C. M., Jones M. P. Enhanced perception of physiological intestinal motility in the irritable bowel syndrome. Gastroenterology. 1991 Dec;101(6):1621–1627. doi: 10.1016/0016-5085(91)90400-f. [DOI] [PubMed] [Google Scholar]
- Kellow J. E., Phillips S. F. Altered small bowel motility in irritable bowel syndrome is correlated with symptoms. Gastroenterology. 1987 Jun;92(6):1885–1893. doi: 10.1016/0016-5085(87)90620-2. [DOI] [PubMed] [Google Scholar]
- Lagier E., Delvaux M., Vellas B., Fioramonti J., Bueno L., Albarede J. L., Frexinos J. Influence of age on rectal tone and sensitivity to distension in healthy subjects. Neurogastroenterol Motil. 1999 Apr;11(2):101–107. doi: 10.1046/j.1365-2982.1999.00145.x. [DOI] [PubMed] [Google Scholar]
- Lasser R. B., Bond J. H., Levitt M. D. The role of intestinal gas in functional abdominal pain. N Engl J Med. 1975 Sep 11;293(11):524–526. doi: 10.1056/NEJM197509112931103. [DOI] [PubMed] [Google Scholar]
- Lembo T., Fullerton S., Diehl D., Raeen H., Munakata J., Naliboff B., Mayer E. A. Symptom duration in patients with irritable bowel syndrome. Am J Gastroenterol. 1996 May;91(5):898–905. [PubMed] [Google Scholar]
- Lembo T., Munakata J., Mertz H., Niazi N., Kodner A., Nikas V., Mayer E. A. Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome. Gastroenterology. 1994 Dec;107(6):1686–1696. doi: 10.1016/0016-5085(94)90809-5. [DOI] [PubMed] [Google Scholar]
- Loening-Baucke V., Anuras S. Effects of age and sex on anorectal manometry. Am J Gastroenterol. 1985 Jan;80(1):50–53. [PubMed] [Google Scholar]
- Loening-Baucke V., Metcalf A. M., Shirazi S. Rectosigmoid motility in patients with quiescent and active ulcerative colitis. Am J Gastroenterol. 1989 Jan;84(1):34–39. [PubMed] [Google Scholar]
- Louvel D., Delvaux M., Staumont G., Camman F., Fioramonti J., Bueno L., Frexinos J. Intracolonic injection of glycerol: a model for abdominal pain in irritable bowel syndrome? Gastroenterology. 1996 Feb;110(2):351–361. doi: 10.1053/gast.1996.v110.pm8566580. [DOI] [PubMed] [Google Scholar]
- Mayer E. A., Raybould H. E. Role of visceral afferent mechanisms in functional bowel disorders. Gastroenterology. 1990 Dec;99(6):1688–1704. doi: 10.1016/0016-5085(90)90475-g. [DOI] [PubMed] [Google Scholar]
- Mei N. Intestinal chemosensitivity. Physiol Rev. 1985 Apr;65(2):211–237. doi: 10.1152/physrev.1985.65.2.211. [DOI] [PubMed] [Google Scholar]
- Mei N. Vagal glucoreceptors in the small intestine of the cat. J Physiol. 1978 Sep;282:485–506. doi: 10.1113/jphysiol.1978.sp012477. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mertz H., Morgan V., Tanner G., Pickens D., Price R., Shyr Y., Kessler R. Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention. Gastroenterology. 2000 May;118(5):842–848. doi: 10.1016/s0016-5085(00)70170-3. [DOI] [PubMed] [Google Scholar]
- Mertz H., Naliboff B., Munakata J., Niazi N., Mayer E. A. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology. 1995 Jul;109(1):40–52. doi: 10.1016/0016-5085(95)90267-8. [DOI] [PubMed] [Google Scholar]
- Naliboff B. D., Munakata J., Fullerton S., Gracely R. H., Kodner A., Harraf F., Mayer E. A. Evidence for two distinct perceptual alterations in irritable bowel syndrome. Gut. 1997 Oct;41(4):505–512. doi: 10.1136/gut.41.4.505. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Narducci F., Snape W. J., Jr, Battle W. M., London R. L., Cohen S. Increased colonic motility during exposure to a stressful situation. Dig Dis Sci. 1985 Jan;30(1):40–44. doi: 10.1007/BF01318369. [DOI] [PubMed] [Google Scholar]
- Neal K. R., Hebden J., Spiller R. Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: postal survey of patients. BMJ. 1997 Mar 15;314(7083):779–782. doi: 10.1136/bmj.314.7083.779. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oettlé G. J., Heaton K. W. "Rectal dissatisfaction" in the irritable bowel syndrome. A manometric and radiological study. Int J Colorectal Dis. 1986 Jul;1(3):183–185. doi: 10.1007/BF01648447. [DOI] [PubMed] [Google Scholar]
- Otake K., Reis D. J., Ruggiero D. A. Afferents to the midline thalamus issue collaterals to the nucleus tractus solitarii: an anatomical basis for thalamic and visceral reflex integration. J Neurosci. 1994 Sep;14(9):5694–5707. doi: 10.1523/JNEUROSCI.14-09-05694.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Plourde V., Lembo T., Shui Z., Parker J., Mertz H., Taché Y., Sytnik B., Mayer E. Effects of the somatostatin analogue octreotide on rectal afferent nerves in humans. Am J Physiol. 1993 Oct;265(4 Pt 1):G742–G751. doi: 10.1152/ajpgi.1993.265.4.G742. [DOI] [PubMed] [Google Scholar]
- Prior A., Maxton D. G., Whorwell P. J. Anorectal manometry in irritable bowel syndrome: differences between diarrhoea and constipation predominant subjects. Gut. 1990 Apr;31(4):458–462. doi: 10.1136/gut.31.4.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rao S. S., Read N. W., Brown C., Bruce C., Holdsworth C. D. Studies on the mechanism of bowel disturbance in ulcerative colitis. Gastroenterology. 1987 Nov;93(5):934–940. doi: 10.1016/0016-5085(87)90554-3. [DOI] [PubMed] [Google Scholar]
- Rao S. S., Read N. W., Stobart J. A., Haynes W. G., Benjamin S., Holdsworth C. D. Anorectal contractility under basal conditions and during rectal infusion of saline in ulcerative colitis. Gut. 1988 Jun;29(6):769–777. doi: 10.1136/gut.29.6.769. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ritchie J. Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut. 1973 Feb;14(2):125–132. doi: 10.1136/gut.14.2.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rouillon J. M., Azpiroz F., Malagelada J. R. Reflex changes in intestinal tone: relationship to perception. Am J Physiol. 1991 Aug;261(2 Pt 1):G280–G286. doi: 10.1152/ajpgi.1991.261.2.G280. [DOI] [PubMed] [Google Scholar]
- Silverman D. H., Munakata J. A., Ennes H., Mandelkern M. A., Hoh C. K., Mayer E. A. Regional cerebral activity in normal and pathological perception of visceral pain. Gastroenterology. 1997 Jan;112(1):64–72. doi: 10.1016/s0016-5085(97)70220-8. [DOI] [PubMed] [Google Scholar]
- Steadman C. J., Phillips S. F., Camilleri M., Haddad A. C., Hanson R. B. Variation of muscle tone in the human colon. Gastroenterology. 1991 Aug;101(2):373–381. doi: 10.1016/0016-5085(91)90014-c. [DOI] [PubMed] [Google Scholar]
- Sun W. M., Read N. W. Anorectal function in normal human subjects: effect of gender. Int J Colorectal Dis. 1989 Aug;4(3):188–196. doi: 10.1007/BF01649702. [DOI] [PubMed] [Google Scholar]
- Thumshirn M., Coulie B., Camilleri M., Zinsmeister A. R., Burton D. D., Van Dyke C. Effects of alosetron on gastrointestinal transit time and rectal sensation in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 2000 Jul;14(7):869–878. doi: 10.1046/j.1365-2036.2000.00786.x. [DOI] [PubMed] [Google Scholar]
- Tjeerdsma H. C., Smout A. J., Akkermans L. M. Voluntary suppression of defecation delays gastric emptying. Dig Dis Sci. 1993 May;38(5):832–836. doi: 10.1007/BF01295908. [DOI] [PubMed] [Google Scholar]
- Trimble K. C., Farouk R., Pryde A., Douglas S., Heading R. C. Heightened visceral sensation in functional gastrointestinal disease is not site-specific. Evidence for a generalized disorder of gut sensitivity. Dig Dis Sci. 1995 Aug;40(8):1607–1613. doi: 10.1007/BF02212678. [DOI] [PubMed] [Google Scholar]
- Vassallo M. J., Camilleri M., Phillips S. F., Steadman C. J., Talley N. J., Hanson R. B., Haddad A. C. Colonic tone and motility in patients with irritable bowel syndrome. Mayo Clin Proc. 1992 Aug;67(8):725–731. doi: 10.1016/s0025-6196(12)60796-4. [DOI] [PubMed] [Google Scholar]
- Whitehead W. E., Delvaux M. Standardization of barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal tract. The Working Team of Glaxo-Wellcome Research, UK. Dig Dis Sci. 1997 Feb;42(2):223–241. doi: 10.1023/a:1018885028501. [DOI] [PubMed] [Google Scholar]
- Whitehead W. E., Engel B. T., Schuster M. M. Irritable bowel syndrome: physiological and psychological differences between diarrhea-predominant and constipation-predominant patients. Dig Dis Sci. 1980 Jun;25(6):404–413. doi: 10.1007/BF01395503. [DOI] [PubMed] [Google Scholar]
- Whitehead W. E., Holtkotter B., Enck P., Hoelzl R., Holmes K. D., Anthony J., Shabsin H. S., Schuster M. M. Tolerance for rectosigmoid distention in irritable bowel syndrome. Gastroenterology. 1990 May;98(5 Pt 1):1187–1192. doi: 10.1016/0016-5085(90)90332-u. [DOI] [PubMed] [Google Scholar]


