Skip to main content
Gut logoLink to Gut
. 2002 Jul;51(Suppl 1):i72–i75. doi: 10.1136/gut.51.suppl_1.i72

Sensation and gas dynamics in functional gastrointestinal disorders

J Malagelada
PMCID: PMC1867726  PMID: 12077071

Full Text

The Full Text of this article is available as a PDF (120.8 KB).

Figure 1 .

Figure 1

Perception of intestinal distension: effect of fat infusion (0.5 kcal/min). *p<0.05 versus saline control. Reproduced from Accarino and colleagues.6

Figure 2 .

Figure 2

Effect of simultaneous conditioning on perception of intestinal distension. Values are mean (SEM). *p<0.05 versus control. Reproduced from Ness and Gebhart.8

Figure 3 .

Figure 3

Intestinal gas dynamics and tolerance in healthy subjects and in patients with irritable bowel syndrome (IBS). Reproduced from Serra and colleagues.24

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Accarino A. M., Azpiroz F., Malagelada J. R. Attention and distraction: effects on gut perception. Gastroenterology. 1997 Aug;113(2):415–422. doi: 10.1053/gast.1997.v113.pm9247458. [DOI] [PubMed] [Google Scholar]
  2. Accarino A. M., Azpiroz F., Malagelada J. R. Modification of small bowel mechanosensitivity by intestinal fat. Gut. 2001 May;48(5):690–695. doi: 10.1136/gut.48.5.690. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Accarino A. M., Azpiroz F., Malagelada J. R. Selective dysfunction of mechanosensitive intestinal afferents in irritable bowel syndrome. Gastroenterology. 1995 Mar;108(3):636–643. doi: 10.1016/0016-5085(95)90434-4. [DOI] [PubMed] [Google Scholar]
  4. Accarino A. M., Azpiroz F., Malagelada J. R. Symptomatic responses to stimulation of sensory pathways in the jejunum. Am J Physiol. 1992 Nov;263(5 Pt 1):G673–G677. doi: 10.1152/ajpgi.1992.263.5.G673. [DOI] [PubMed] [Google Scholar]
  5. Camilleri M., Mayer E. A., Drossman D. A., Heath A., Dukes G. E., McSorley D., Kong S., Mangel A. W., Northcutt A. R. Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5-HT3 receptor antagonist. Aliment Pharmacol Ther. 1999 Sep;13(9):1149–1159. doi: 10.1046/j.1365-2036.1999.00610.x. [DOI] [PubMed] [Google Scholar]
  6. Carryer P. W., Brown M. I., Malagelada J. R., Carlson G. L., McCall J. T. Quantification of the fate of dietary fiber in humans by a newly developed radiolabeled fiber marker. Gastroenterology. 1982 Jun;82(6):1389–1394. [PubMed] [Google Scholar]
  7. Clouse R. E. Antidepressants for functional gastrointestinal syndromes. Dig Dis Sci. 1994 Nov;39(11):2352–2363. doi: 10.1007/BF02087651. [DOI] [PubMed] [Google Scholar]
  8. Coffin B., Azpiroz F., Malagelada J. R. Somatic stimulation reduces perception of gut distention in humans. Gastroenterology. 1994 Dec;107(6):1636–1642. doi: 10.1016/0016-5085(94)90802-8. [DOI] [PubMed] [Google Scholar]
  9. De Ponti F., Malagelada J. R. Functional gut disorders: from motility to sensitivity disorders. A review of current and investigational drugs for their management. Pharmacol Ther. 1998 Oct;80(1):49–88. doi: 10.1016/s0163-7258(98)00021-7. [DOI] [PubMed] [Google Scholar]
  10. Gwee K. A., Leong Y. L., Graham C., McKendrick M. W., Collins S. M., Walters S. J., Underwood J. E., Read N. W. The role of psychological and biological factors in postinfective gut dysfunction. Gut. 1999 Mar;44(3):400–406. doi: 10.1136/gut.44.3.400. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Iovino P., Azpiroz F., Domingo E., Malagelada J. R. The sympathetic nervous system modulates perception and reflex responses to gut distention in humans. Gastroenterology. 1995 Mar;108(3):680–686. doi: 10.1016/0016-5085(95)90439-5. [DOI] [PubMed] [Google Scholar]
  12. Levitt M. D., Furne J., Olsson S. The relation of passage of gas an abdominal bloating to colonic gas production. Ann Intern Med. 1996 Feb 15;124(4):422–424. doi: 10.7326/0003-4819-124-4-199602150-00006. [DOI] [PubMed] [Google Scholar]
  13. Malagelada J. R. Quantificantion of gastric solid-liquid discrimination during digestion of ordinary meals. Gastroenterology. 1977 Jun;72(6):1264–1267. [PubMed] [Google Scholar]
  14. Neal K. R., Hebden J., Spiller R. Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: postal survey of patients. BMJ. 1997 Mar 15;314(7083):779–782. doi: 10.1136/bmj.314.7083.779. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Ness T. J., Gebhart G. F. Visceral pain: a review of experimental studies. Pain. 1990 May;41(2):167–234. doi: 10.1016/0304-3959(90)90021-5. [DOI] [PubMed] [Google Scholar]
  16. Notivol R., Coffin B., Azpiroz F., Mearin F., Serra J., Malagelada J. R. Gastric tone determines the sensitivity of the stomach to distention. Gastroenterology. 1995 Feb;108(2):330–336. doi: 10.1016/0016-5085(95)90057-8. [DOI] [PubMed] [Google Scholar]
  17. Richeimer S. H., Bajwa Z. H., Kahraman S. S., Ransil B. J., Warfield C. A. Utilization patterns of tricyclic antidepressants in a multidisciplinary pain clinic: a survey. Clin J Pain. 1997 Dec;13(4):324–329. doi: 10.1097/00002508-199712000-00010. [DOI] [PubMed] [Google Scholar]
  18. Serra J., Azpiroz F., Malagelada J. R. Impaired transit and tolerance of intestinal gas in the irritable bowel syndrome. Gut. 2001 Jan;48(1):14–19. doi: 10.1136/gut.48.1.14. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Serra J., Azpiroz F., Malagelada J. R. Intestinal gas dynamics and tolerance in humans. Gastroenterology. 1998 Sep;115(3):542–550. doi: 10.1016/s0016-5085(98)70133-7. [DOI] [PubMed] [Google Scholar]
  20. Serra J., Azpiroz F., Malagelada J. R. Mechanisms of intestinal gas retention in humans: impaired propulsion versus obstructed evacuation. Am J Physiol Gastrointest Liver Physiol. 2001 Jul;281(1):G138–G143. doi: 10.1152/ajpgi.2001.281.1.G138. [DOI] [PubMed] [Google Scholar]
  21. Serra J., Azpiroz F., Malagelada J. R. Modulation of gut perception in humans by spatial summation phenomena. J Physiol. 1998 Jan 15;506(Pt 2):579–587. doi: 10.1111/j.1469-7793.1998.579bw.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Serra J., Azpiroz F., Malagelada J. R. Perception and reflex responses to intestinal distention in humans are modified by simultaneous or previous stimulation. Gastroenterology. 1995 Dec;109(6):1742–1749. doi: 10.1016/0016-5085(95)90739-4. [DOI] [PubMed] [Google Scholar]
  23. Talley N. J., Boyce P., Jones M. Identification of distinct upper and lower gastrointestinal symptom groupings in an urban population. Gut. 1998 May;42(5):690–695. doi: 10.1136/gut.42.5.690. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Villanova N., Azpiroz F., Malagelada J. R. Perception and gut reflexes induced by stimulation of gastrointestinal thermoreceptors in humans. J Physiol. 1997 Jul 1;502(Pt 1):215–222. doi: 10.1111/j.1469-7793.1997.215bl.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES