Full Text
The Full Text of this article is available as a PDF (114.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Achkar J. P., Araya V., Baron R. L., Marsh J. W., Dvorchik I., Rakela J. Undetected hepatocellular carcinoma: clinical features and outcome after liver transplantation. Liver Transpl Surg. 1998 Nov;4(6):477–482. doi: 10.1002/lt.500040604. [DOI] [PubMed] [Google Scholar]
- Adachi E., Maeda T., Matsumata T., Shirabe K., Kinukawa N., Sugimachi K., Tsuneyoshi M. Risk factors for intrahepatic recurrence in human small hepatocellular carcinoma. Gastroenterology. 1995 Mar;108(3):768–775. doi: 10.1016/0016-5085(95)90450-6. [DOI] [PubMed] [Google Scholar]
- Allgaier H. P., Deibert P., Zuber I., Olschewski M., Blum H. E. Percutaneous radiofrequency interstitial thermal ablation of small hepatocellular carcinoma. Lancet. 1999 May 15;353(9165):1676–1677. doi: 10.1016/S0140-6736(99)00368-2. [DOI] [PubMed] [Google Scholar]
- Barbara L., Benzi G., Gaiani S., Fusconi F., Zironi G., Siringo S., Rigamonti A., Barbara C., Grigioni W., Mazziotti A. Natural history of small untreated hepatocellular carcinoma in cirrhosis: a multivariate analysis of prognostic factors of tumor growth rate and patient survival. Hepatology. 1992 Jul;16(1):132–137. doi: 10.1002/hep.1840160122. [DOI] [PubMed] [Google Scholar]
- Bartolozzi C., Lencioni R., Caramella D., Palla A., Bassi A. M., Di Candio G. Small hepatocellular carcinoma. Detection with US, CT, MR imaging, DSA, and Lipiodol-CT. Acta Radiol. 1996 Jan;37(1):69–74. doi: 10.1177/02841851960371P114. [DOI] [PubMed] [Google Scholar]
- Bartolozzi C., Lencioni R., Caramella D., Vignali C., Cioni R., Mazzeo S., Carrai M., Maltinti G., Capria A., Conte P. F. Treatment of large HCC: transcatheter arterial chemoembolization combined with percutaneous ethanol injection versus repeated transcatheter arterial chemoembolization. Radiology. 1995 Dec;197(3):812–818. doi: 10.1148/radiology.197.3.7480761. [DOI] [PubMed] [Google Scholar]
- Bismuth H., Chiche L., Adam R., Castaing D., Diamond T., Dennison A. Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg. 1993 Aug;218(2):145–151. doi: 10.1097/00000658-199308000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bizollon T., Rode A., Bancel B., Gueripel V., Ducerf C., Baulieux J., Trepo C. Diagnostic value and tolerance of Lipiodol-computed tomography for the detection of small hepatocellular carcinoma: correlation with pathologic examination of explanted livers. J Hepatol. 1998 Mar;28(3):491–496. doi: 10.1016/s0168-8278(98)80324-3. [DOI] [PubMed] [Google Scholar]
- Bruix J., Llovet J. M., Castells A., Montañ X., Brú C., Ayuso M. C., Vilana R., Rodés J. Transarterial embolization versus symptomatic treatment in patients with advanced hepatocellular carcinoma: results of a randomized, controlled trial in a single institution. Hepatology. 1998 Jun;27(6):1578–1583. doi: 10.1002/hep.510270617. [DOI] [PubMed] [Google Scholar]
- Castells A., Bruix J., Bru C., Fuster J., Vilana R., Navasa M., Ayuso C., Boix L., Visa J., Rodés J. Treatment of small hepatocellular carcinoma in cirrhotic patients: a cohort study comparing surgical resection and percutaneous ethanol injection. Hepatology. 1993 Nov;18(5):1121–1126. [PubMed] [Google Scholar]
- Castells A., Bruix J., Brú C., Ayuso C., Roca M., Boix L., Vilana R., Rodés J. Treatment of hepatocellular carcinoma with tamoxifen: a double-blind placebo-controlled trial in 120 patients. Gastroenterology. 1995 Sep;109(3):917–922. doi: 10.1016/0016-5085(95)90402-6. [DOI] [PubMed] [Google Scholar]
- Colombo M., Sangiovanni A. The natural history of hepatocellular carcinoma. Ital J Gastroenterol. 1992 Feb;24(2):95–99. [PubMed] [Google Scholar]
- Colombo M., de Franchis R., Del Ninno E., Sangiovanni A., De Fazio C., Tommasini M., Donato M. F., Piva A., Di Carlo V., Dioguardi N. Hepatocellular carcinoma in Italian patients with cirrhosis. N Engl J Med. 1991 Sep 5;325(10):675–680. doi: 10.1056/NEJM199109053251002. [DOI] [PubMed] [Google Scholar]
- Cottone M., Virdone R., Fusco G., Orlando A., Turri M., Caltagirone M., Maringhini A., Sciarrino E., Demma I., Nicoli N. Asymptomatic hepatocellular carcinoma in Child's A cirrhosis. A comparison of natural history and surgical treatment. Gastroenterology. 1989 Jun;96(6):1566–1571. doi: 10.1016/0016-5085(89)90528-3. [DOI] [PubMed] [Google Scholar]
- Craig J. R., Peters R. L., Edmondson H. A., Omata M. Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinico-pathologic features. Cancer. 1980 Jul 15;46(2):372–379. doi: 10.1002/1097-0142(19800715)46:2<372::aid-cncr2820460227>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
- Curley S. A., Izzo F., Ellis L. M., Nicolas Vauthey J., Vallone P. Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann Surg. 2000 Sep;232(3):381–391. doi: 10.1097/00000658-200009000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Das D. K. Cytodiagnosis of hepatocellular carcinoma in fine-needle aspirates of the liver: its differentiation from reactive hepatocytes and metastatic adenocarcinoma. Diagn Cytopathol. 1999 Dec;21(6):370–377. doi: 10.1002/(sici)1097-0339(199912)21:6<370::aid-dc2>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
- De Mitri M. S., Poussin K., Baccarini P., Pontisso P., D'Errico A., Simon N., Grigioni W., Alberti A., Beaugrand M., Pisi E. HCV-associated liver cancer without cirrhosis. Lancet. 1995 Feb 18;345(8947):413–415. doi: 10.1016/s0140-6736(95)90400-x. [DOI] [PubMed] [Google Scholar]
- Di Stasi M., Buscarini L., Livraghi T., Giorgio A., Salmi A., De Sio I., Brunello F., Solmi L., Caturelli E., Magnolfi F. Percutaneous ethanol injection in the treatment of hepatocellular carcinoma. A multicenter survey of evaluation practices and complication rates. Scand J Gastroenterol. 1997 Nov;32(11):1168–1173. doi: 10.3109/00365529709002998. [DOI] [PubMed] [Google Scholar]
- Doyon D., Mouzon A., Jourde A. M., Regensberg C., Frileux C. L'embolisation artérielle hépatique dans les tumeurs malignes du foie. Ann Radiol (Paris) 1974 Oct;17(6):593–603. [PubMed] [Google Scholar]
- El-Serag H. B., Mason A. C. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 1999 Mar 11;340(10):745–750. doi: 10.1056/NEJM199903113401001. [DOI] [PubMed] [Google Scholar]
- Elba S., Giannuzzi V., Misciagna G., Manghisi O. G. Randomized controlled trial of tamoxifen versus placebo in inoperable hepatocellular carcinoma. Ital J Gastroenterol. 1994 Mar;26(2):66–68. [PubMed] [Google Scholar]
- Fan S. T., Lo C. M., Lai E. C., Chu K. M., Liu C. L., Wong J. Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma. N Engl J Med. 1994 Dec 8;331(23):1547–1552. doi: 10.1056/NEJM199412083312303. [DOI] [PubMed] [Google Scholar]
- Farinati F., De Maria N., Fornasiero A., Salvagnini M., Fagiuoli S., Chiaramonte M., Naccarato R. Prospective controlled trial with antiestrogen drug tamoxifen in patients with unresectable hepatocellular carcinoma. Dig Dis Sci. 1992 May;37(5):659–662. doi: 10.1007/BF01296419. [DOI] [PubMed] [Google Scholar]
- Francica G., Marone G. Ultrasound-guided percutaneous treatment of hepatocellular carcinoma by radiofrequency hyperthermia with a 'cooled-tip needle'. A preliminary clinical experience. Eur J Ultrasound. 1999 May;9(2):145–153. doi: 10.1016/s0929-8266(99)00022-1. [DOI] [PubMed] [Google Scholar]
- Franco D., Capussotti L., Smadja C., Bouzari H., Meakins J., Kemeny F., Grange D., Dellepiane M. Resection of hepatocellular carcinomas. Results in 72 European patients with cirrhosis. Gastroenterology. 1990 Mar;98(3):733–738. [PubMed] [Google Scholar]
- Frazer C. Imaging of hepatocellular carcinoma. J Gastroenterol Hepatol. 1999 Aug;14(8):750–756. doi: 10.1046/j.1440-1746.1999.01946.x. [DOI] [PubMed] [Google Scholar]
- Gebbia V., Maiello E., Serravezza G., Giotta F., Testa A., Borsellino N., Pezzella G., Colucci G. 5-Fluorouracil plus high dose levofolinic acid and oral hydroxyurea for the treatment of primary hepatocellular carcinomas: results of a phase II multicenter study of the Southern Italy Oncology Group (G.O.I.M.). Anticancer Res. 1999 Mar-Apr;19(2B):1407–1410. [PubMed] [Google Scholar]
- Goh J., Callagy G., McEntee G., O'Keane J. C., Bomford A., Crowe J. Hepatocellular carcinoma arising in the absence of cirrhosis in genetic haemochromatosis: three case reports and review of literature. Eur J Gastroenterol Hepatol. 1999 Aug;11(8):915–919. doi: 10.1097/00042737-199908000-00019. [DOI] [PubMed] [Google Scholar]
- Grando-Lemaire V., Guettier C., Chevret S., Beaugrand M., Trinchet J. C. Hepatocellular carcinoma without cirrhosis in the West: epidemiological factors and histopathology of the non-tumorous liver. Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire. J Hepatol. 1999 Sep;31(3):508–513. doi: 10.1016/s0168-8278(99)80044-0. [DOI] [PubMed] [Google Scholar]
- Halm U., Etzrodt G., Schiefke I., Schmidt F., Witzigmann H., Mössner J., Berr F. A phase II study of pegylated liposomal doxorubicin for treatment of advanced hepatocellular carcinoma. Ann Oncol. 2000 Jan;11(1):113–114. doi: 10.1023/a:1008386822906. [DOI] [PubMed] [Google Scholar]
- Horigome H., Nomura T., Saso K., Itoh M., Joh T., Ohara H. Limitations of imaging diagnosis for small hepatocellular carcinoma: comparison with histological findings. J Gastroenterol Hepatol. 1999 Jun;14(6):559–565. doi: 10.1046/j.1440-1746.1999.01915.x. [DOI] [PubMed] [Google Scholar]
- Houben K. W., McCall J. L. Liver transplantation for hepatocellular carcinoma in patients without underlying liver disease: a systematic review. Liver Transpl Surg. 1999 Mar;5(2):91–95. doi: 10.1002/lt.500050201. [DOI] [PubMed] [Google Scholar]
- Howel D., Metcalf J. V., Gray J., Newman W. L., Jones D. E., James O. F. Cancer risk in primary biliary cirrhosis: a study in northern England. Gut. 1999 Nov;45(5):756–760. doi: 10.1136/gut.45.5.756. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Huang G. T., Sheu J. C., Yang P. M., Lee H. S., Wang T. H., Chen D. S. Ultrasound-guided cutting biopsy for the diagnosis of hepatocellular carcinoma--a study based on 420 patients. J Hepatol. 1996 Sep;25(3):334–338. doi: 10.1016/s0168-8278(96)80120-6. [DOI] [PubMed] [Google Scholar]
- Inoue A., Tsukuma H., Oshima A., Yabuuchi T., Nakao M., Matsunaga T., Kojima J., Tanaka S. Effectiveness of interferon therapy for reducing the incidence of hepatocellular carcinoma among patients with type C chronic hepatitis. J Epidemiol. 2000 Jul;10(4):234–240. doi: 10.2188/jea.10.234. [DOI] [PubMed] [Google Scholar]
- Ishii H., Okada S., Okusaka T., Yoshimori M., Nakasuka H., Shimada K., Yamasaki S., Nakanishi Y., Sakamoto M. Needle tract implantation of hepatocellular carcinoma after percutaneous ethanol injection. Cancer. 1998 May 1;82(9):1638–1642. [PubMed] [Google Scholar]
- Iwatsuki S., Starzl T. E. Personal experience with 411 hepatic resections. Ann Surg. 1988 Oct;208(4):421–434. doi: 10.1097/00000658-198810000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Iwatsuki S., Starzl T. E., Sheahan D. G., Yokoyama I., Demetris A. J., Todo S., Tzakis A. G., Van Thiel D. H., Carr B., Selby R. Hepatic resection versus transplantation for hepatocellular carcinoma. Ann Surg. 1991 Sep;214(3):221–229. doi: 10.1097/00000658-199109000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kanematsu M., Hoshi H., Yamada T., Murakami T., Kim T., Kato M., Yokoyama R., Nakamura H. Small hepatic nodules in cirrhosis: ultrasonographic, CT, and MR imaging findings. Abdom Imaging. 1999 Jan-Feb;24(1):47–55. doi: 10.1007/s002619900439. [DOI] [PubMed] [Google Scholar]
- Kanematsu T., Sonoda T., Takenaka K., Matsumata T., Sugimachi K., Inokuchi K. The value of ultrasound in the diagnosis and treatment of small hepatocellular carcinoma. Br J Surg. 1985 Jan;72(1):23–25. doi: 10.1002/bjs.1800720111. [DOI] [PubMed] [Google Scholar]
- Kanematsu T., Takenaka K., Matsumata T., Furuta T., Sugimachi K., Inokuchi K. Limited hepatic resection effective for selected cirrhotic patients with primary liver cancer. Ann Surg. 1984 Jan;199(1):51–56. doi: 10.1097/00000658-198401000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kasahara A., Hayashi N., Mochizuki K., Takayanagi M., Yoshioka K., Kakumu S., Iijima A., Urushihara A., Kiyosawa K., Okuda M. Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. Osaka Liver Disease Study Group. Hepatology. 1998 May;27(5):1394–1402. doi: 10.1002/hep.510270529. [DOI] [PubMed] [Google Scholar]
- Kasugai H., Kojima J., Tatsuta M., Okuda S., Sasaki Y., Imaoka S., Fujita M., Ishiguro S. Treatment of hepatocellular carcinoma by transcatheter arterial embolization combined with intraarterial infusion of a mixture of cisplatin and ethiodized oil. Gastroenterology. 1989 Oct;97(4):965–971. doi: 10.1016/0016-5085(89)91505-9. [DOI] [PubMed] [Google Scholar]
- Kouroumalis E., Skordilis P., Thermos K., Vasilaki A., Moschandrea J., Manousos O. N. Treatment of hepatocellular carcinoma with octreotide: a randomised controlled study. Gut. 1998 Mar;42(3):442–447. doi: 10.1136/gut.42.3.442. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kowdley K. V. Does interferon therapy prevent hepatocellular carcinoma in patients with chronic hepatitis C? Gastroenterology. 1999 Sep;117(3):738–739. doi: 10.1016/s0016-5085(99)70471-3. [DOI] [PubMed] [Google Scholar]
- Kuroda C., Iwasaki M., Tanaka T., Tokunaga K., Hori S., Yoshioka H., Nakamura H., Sakurai M., Okamura J. Gallbladder infarction following hepatic transcatheter arterial embolization. Angiographic study. Radiology. 1983 Oct;149(1):85–89. doi: 10.1148/radiology.149.1.6310685. [DOI] [PubMed] [Google Scholar]
- Lai C. L., Lau J. Y., Wu P. C., Ngan H., Chung H. T., Mitchell S. J., Corbett T. J., Chow A. W., Lin H. J. Recombinant interferon-alpha in inoperable hepatocellular carcinoma: a randomized controlled trial. Hepatology. 1993 Mar;17(3):389–394. [PubMed] [Google Scholar]
- Lai E. C., Fan S. T., Lo C. M., Chu K. M., Liu C. L., Wong J. Hepatic resection for hepatocellular carcinoma. An audit of 343 patients. Ann Surg. 1995 Mar;221(3):291–298. doi: 10.1097/00000658-199503000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lee C. M., Lu S. N., Changchien C. S., Yeh C. T., Hsu T. T., Tang J. H., Wang J. H., Lin D. Y., Chen C. L., Chen W. J. Age, gender, and local geographic variations of viral etiology of hepatocellular carcinoma in a hyperendemic area for hepatitis B virus infection. Cancer. 1999 Oct 1;86(7):1143–1150. doi: 10.1002/(sici)1097-0142(19991001)86:7<1143::aid-cncr7>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
- Lee F. I. Cirrhosis and hepatoma in alcoholics. Gut. 1966 Feb;7(1):77–85. doi: 10.1136/gut.7.1.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lee H. S., Han C. J., Kim C. Y. Predominant etiologic association of hepatitis C virus with hepatocellular carcinoma compared with hepatitis B virus in elderly patients in a hepatitis B-endemic area. Cancer. 1993 Nov 1;72(9):2564–2567. doi: 10.1002/1097-0142(19931101)72:9<2564::aid-cncr2820720909>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
- Lencioni R., Pinto F., Armillotta N., Bassi A. M., Moretti M., Di Giulio M., Marchi S., Uliana M., Della Capanna S., Lencioni M. Long-term results of percutaneous ethanol injection therapy for hepatocellular carcinoma in cirrhosis: a European experience. Eur Radiol. 1997;7(4):514–519. doi: 10.1007/s003300050194. [DOI] [PubMed] [Google Scholar]
- Lencioni R., Vignali C., Caramella D., Cioni R., Mazzeo S., Bartolozzi C. Transcatheter arterial embolization followed by percutaneous ethanol injection in the treatment of hepatocellular carcinoma. Cardiovasc Intervent Radiol. 1994 Mar-Apr;17(2):70–75. doi: 10.1007/BF00193920. [DOI] [PubMed] [Google Scholar]
- Liaw Y. F., Tai D. I., Chu C. M., Lin D. Y., Sheen I. S., Chen T. J., Pao C. C. Early detection of hepatocellular carcinoma in patients with chronic type B hepatitis. A prospective study. Gastroenterology. 1986 Feb;90(2):263–267. doi: 10.1016/0016-5085(86)90919-4. [DOI] [PubMed] [Google Scholar]
- Liebman H. A., Furie B. C., Tong M. J., Blanchard R. A., Lo K. J., Lee S. D., Coleman M. S., Furie B. Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma. N Engl J Med. 1984 May 31;310(22):1427–1431. doi: 10.1056/NEJM198405313102204. [DOI] [PubMed] [Google Scholar]
- Lin D. Y., Liaw Y. F., Lee T. Y., Lai C. M. Hepatic arterial embolization in patients with unresectable hepatocellular carcinoma--a randomized controlled trial. Gastroenterology. 1988 Feb;94(2):453–456. doi: 10.1016/0016-5085(88)90436-2. [DOI] [PubMed] [Google Scholar]
- Lin S. M., Lin D. Y., Lin C. J. Percutaneous ethanol injection therapy in 47 cirrhotic patients with hepatocellular carcinoma 5 cm or less: a long-term result. Int J Clin Pract. 1999 Jun;53(4):257–262. [PubMed] [Google Scholar]
- Liu C. L., Fan S. T., Ng I. O., Lo C. M., Poon R. T., Wong J. Treatment of advanced hepatocellular carcinoma with tamoxifen and the correlation with expression of hormone receptors: a prospective randomized study. Am J Gastroenterol. 2000 Jan;95(1):218–222. doi: 10.1111/j.1572-0241.2000.01688.x. [DOI] [PubMed] [Google Scholar]
- Livraghi T., Bolondi L., Buscarini L., Cottone M., Mazziotti A., Morabito A., Torzilli G. No treatment, resection and ethanol injection in hepatocellular carcinoma: a retrospective analysis of survival in 391 patients with cirrhosis. Italian Cooperative HCC Study Group. J Hepatol. 1995 May;22(5):522–526. doi: 10.1016/0168-8278(95)80445-5. [DOI] [PubMed] [Google Scholar]
- Livraghi T., Bolondi L., Lazzaroni S., Marin G., Morabito A., Rapaccini G. L., Salmi A., Torzilli G. Percutaneous ethanol injection in the treatment of hepatocellular carcinoma in cirrhosis. A study on 207 patients. Cancer. 1992 Feb 15;69(4):925–929. doi: 10.1002/1097-0142(19920215)69:4<925::aid-cncr2820690415>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
- Livraghi T., Giorgio A., Marin G., Salmi A., de Sio I., Bolondi L., Pompili M., Brunello F., Lazzaroni S., Torzilli G. Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injection. Radiology. 1995 Oct;197(1):101–108. doi: 10.1148/radiology.197.1.7568806. [DOI] [PubMed] [Google Scholar]
- Livraghi T., Goldberg S. N., Lazzaroni S., Meloni F., Ierace T., Solbiati L., Gazelle G. S. Hepatocellular carcinoma: radio-frequency ablation of medium and large lesions. Radiology. 2000 Mar;214(3):761–768. doi: 10.1148/radiology.214.3.r00mr02761. [DOI] [PubMed] [Google Scholar]
- Livraghi T., Goldberg S. N., Lazzaroni S., Meloni F., Solbiati L., Gazelle G. S. Small hepatocellular carcinoma: treatment with radio-frequency ablation versus ethanol injection. Radiology. 1999 Mar;210(3):655–661. doi: 10.1148/radiology.210.3.r99fe40655. [DOI] [PubMed] [Google Scholar]
- Llovet J. M., Bruix J., Fuster J., Castells A., Garcia-Valdecasas J. C., Grande L., Franca A., Brú C., Navasa M., Ayuso M. C. Liver transplantation for small hepatocellular carcinoma: the tumor-node-metastasis classification does not have prognostic power. Hepatology. 1998 Jun;27(6):1572–1577. doi: 10.1002/hep.510270616. [DOI] [PubMed] [Google Scholar]
- Llovet J. M., Fuster J., Bruix J. Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation. Hepatology. 1999 Dec;30(6):1434–1440. doi: 10.1002/hep.510300629. [DOI] [PubMed] [Google Scholar]
- Llovet J. M., Sala M., Castells L., Suarez Y., Vilana R., Bianchi L., Ayuso C., Vargas V., Rodés J., Bruix J. Randomized controlled trial of interferon treatment for advanced hepatocellular carcinoma. Hepatology. 2000 Jan;31(1):54–58. doi: 10.1002/hep.510310111. [DOI] [PubMed] [Google Scholar]
- Llovet Josep M., Real Maria Isabel, Montaña Xavier, Planas Ramon, Coll Susana, Aponte John, Ayuso Carmen, Sala Margarita, Muchart Jordi, Solà Ricard. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet. 2002 May 18;359(9319):1734–1739. doi: 10.1016/S0140-6736(02)08649-X. [DOI] [PubMed] [Google Scholar]
- Lo Chung-Mau, Ngan Henry, Tso Wai-Kuen, Liu Chi-Leung, Lam Chi-Ming, Poon Ronnie Tung-Ping, Fan Sheung-Tat, Wong John. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology. 2002 May;35(5):1164–1171. doi: 10.1053/jhep.2002.33156. [DOI] [PubMed] [Google Scholar]
- Lok A. S., Lai C. L. alpha-Fetoprotein monitoring in Chinese patients with chronic hepatitis B virus infection: role in the early detection of hepatocellular carcinoma. Hepatology. 1989 Jan;9(1):110–115. doi: 10.1002/hep.1840090119. [DOI] [PubMed] [Google Scholar]
- Löf L., Adami H. O., Sparén P., Danielsson A., Eriksson L. S., Hultcrantz R., Lindgren S., Olsson R., Prytz H., Ryden B. O. Cancer risk in primary biliary cirrhosis: a population-based study from Sweden. Hepatology. 1994 Jul;20(1 Pt 1):101–104. [PubMed] [Google Scholar]
- Madden M. V., Krige J. E., Bailey S., Beningfield S. J., Geddes C., Werner I. D., Terblanche J. Randomised trial of targeted chemotherapy with lipiodol and 5-epidoxorubicin compared with symptomatic treatment for hepatoma. Gut. 1993 Nov;34(11):1598–1600. doi: 10.1136/gut.34.11.1598. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Martínez Cerezo F. J., Tomás A., Donoso L., Enríquez J., Guarner C., Balanzó J., Martínez Nogueras A., Vilardell F. Controlled trial of tamoxifen in patients with advanced hepatocellular carcinoma. J Hepatol. 1994 Jun;20(6):702–706. doi: 10.1016/s0168-8278(05)80138-2. [DOI] [PubMed] [Google Scholar]
- McMahon B. J., Alberts S. R., Wainwright R. B., Bulkow L., Lanier A. P. Hepatitis B-related sequelae. Prospective study in 1400 hepatitis B surface antigen-positive Alaska native carriers. Arch Intern Med. 1990 May;150(5):1051–1054. doi: 10.1001/archinte.150.5.1051. [DOI] [PubMed] [Google Scholar]
- McPeake J. R., O'Grady J. G., Zaman S., Portmann B., Wight D. G., Tan K. C., Calne R. Y., Williams R. Liver transplantation for primary hepatocellular carcinoma: tumor size and number determine outcome. J Hepatol. 1993 Jun;18(2):226–234. doi: 10.1016/s0168-8278(05)80250-8. [DOI] [PubMed] [Google Scholar]
- Mima S., Sekiya C., Kanagawa H., Kohyama H., Gotoh K., Mizuo H., Ijiri M., Tanabe T., Maeda N., Okuda K. Mass screening for hepatocellular carcinoma: experience in Hokkaido, Japan. J Gastroenterol Hepatol. 1994 Jul-Aug;9(4):361–365. doi: 10.1111/j.1440-1746.1994.tb01256.x. [DOI] [PubMed] [Google Scholar]
- Miyajima I., Sata M., Kumashiro R., Uchimura Y., Ide T., Suzuki H., Tanikawa K. The incidence of hepatocellular carcinoma in patients with chronic hepatitis C after interferon treatment. Oncol Rep. 1998 Jan-Feb;5(1):201–204. [PubMed] [Google Scholar]
- Morris D. E., Abouljoud M. Short-term results of radiofrequency ablation in liver tumors. Am J Surg. 2000 Jun;179(6):527–527. doi: 10.1016/s0002-9610(00)00254-3. [DOI] [PubMed] [Google Scholar]
- Muto Y., Moriwaki H., Saito A. Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma. N Engl J Med. 1999 Apr 1;340(13):1046–1047. doi: 10.1056/NEJM199904013401315. [DOI] [PubMed] [Google Scholar]
- Nagorney D. M., Adson M. A., Weiland L. H., Knight C. D., Jr, Smalley S. R., Zinsmeister A. R. Fibrolamellar hepatoma. Am J Surg. 1985 Jan;149(1):113–119. doi: 10.1016/s0002-9610(85)80019-2. [DOI] [PubMed] [Google Scholar]
- Niederau C., Fischer R., Pürschel A., Stremmel W., Häussinger D., Strohmeyer G. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology. 1996 Apr;110(4):1107–1119. doi: 10.1053/gast.1996.v110.pm8613000. [DOI] [PubMed] [Google Scholar]
- Nishiguchi S., Kuroki T., Nakatani S., Morimoto H., Takeda T., Nakajima S., Shiomi S., Seki S., Kobayashi K., Otani S. Randomised trial of effects of interferon-alpha on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis. Lancet. 1995 Oct 21;346(8982):1051–1055. doi: 10.1016/s0140-6736(95)91739-x. [DOI] [PubMed] [Google Scholar]
- O'Grady J. G., Polson R. J., Rolles K., Calne R. Y., Williams R. Liver transplantation for malignant disease. Results in 93 consecutive patients. Ann Surg. 1988 Apr;207(4):373–379. doi: 10.1097/00000658-198804000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ohmoto K., Yamamoto S. Percutaneous microwave coagulation therapy for superficial hepatocellular carcinoma on the liver surface. Am J Gastroenterol. 2000 Sep;95(9):2401–2403. doi: 10.1111/j.1572-0241.2000.02355.x. [DOI] [PubMed] [Google Scholar]
- Ohnishi K. Comparison of percutaneous acetic acid injection and percutaneous ethanol injection for small hepatocellular carcinoma. Hepatogastroenterology. 1998 Aug;45 (Suppl 3):1254–1258. [PubMed] [Google Scholar]
- Ohnishi K., Yoshioka H., Ito S., Fujiwara K. Prospective randomized controlled trial comparing percutaneous acetic acid injection and percutaneous ethanol injection for small hepatocellular carcinoma. Hepatology. 1998 Jan;27(1):67–72. doi: 10.1002/hep.510270112. [DOI] [PubMed] [Google Scholar]
- Oka H., Kurioka N., Kim K., Kanno T., Kuroki T., Mizoguchi Y., Kobayashi K. Prospective study of early detection of hepatocellular carcinoma in patients with cirrhosis. Hepatology. 1990 Oct;12(4 Pt 1):680–687. doi: 10.1002/hep.1840120411. [DOI] [PubMed] [Google Scholar]
- Okazaki M., Higashihara H., Koganemaru F., Nakamura T., Kitsuki H., Hoashi T., Makuuchi M. Intraperitoneal hemorrhage from hepatocellular carcinoma: emergency chemoembolization or embolization. Radiology. 1991 Sep;180(3):647–651. doi: 10.1148/radiology.180.3.1651524. [DOI] [PubMed] [Google Scholar]
- Okazaki N., Yoshino M., Yoshida T., Suzuki M., Moriyama N., Takayasu K., Makuuchi M., Yamazaki S., Hasegawa H., Noguchi M. Evaluation of the prognosis for small hepatocellular carcinoma based on tumor volume doubling time. A preliminary report. Cancer. 1989 Jun 1;63(11):2207–2210. doi: 10.1002/1097-0142(19890601)63:11<2207::aid-cncr2820631124>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
- Okuda K. Early recognition of hepatocellular carcinoma. Hepatology. 1986 Jul-Aug;6(4):729–738. doi: 10.1002/hep.1840060432. [DOI] [PubMed] [Google Scholar]
- Okuda K., Fujimoto I., Hanai A., Urano Y. Changing incidence of hepatocellular carcinoma in Japan. Cancer Res. 1987 Sep 15;47(18):4967–4972. [PubMed] [Google Scholar]
- Okuda K., Nakashima T., Sakamoto K., Ikari T., Hidaka H., Kubo Y., Sakuma K., Motoike Y., Okuda H., Obata H. Hepatocellular carcinoma arising in noncirrhotic and highly cirrhotic livers: a comparative study of histopathology and frequency of hepatitis B markers. Cancer. 1982 Feb 1;49(3):450–455. doi: 10.1002/1097-0142(19820201)49:3<450::aid-cncr2820490310>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
- Otto G., Heuschen U., Hofmann W. J., Krumm G., Hinz U., Herfarth C. Survival and recurrence after liver transplantation versus liver resection for hepatocellular carcinoma: a retrospective analysis. Ann Surg. 1998 Mar;227(3):424–432. doi: 10.1097/00000658-199803000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ouchi K., Matsubara S., Fukuhara K., Tominaga T., Matsuno S. Recurrence of hepatocellular carcinoma in the liver remnant after hepatic resection. Am J Surg. 1993 Sep;166(3):270–273. doi: 10.1016/s0002-9610(05)80972-9. [DOI] [PubMed] [Google Scholar]
- Pelletier G., Ducreux M., Gay F., Luboinski M., Hagège H., Dao T., Van Steenbergen W., Buffet C., Rougier P., Adler M. Treatment of unresectable hepatocellular carcinoma with lipiodol chemoembolization: a multicenter randomized trial. Groupe CHC. J Hepatol. 1998 Jul;29(1):129–134. doi: 10.1016/s0168-8278(98)80187-6. [DOI] [PubMed] [Google Scholar]
- Pelletier G., Roche A., Ink O., Anciaux M. L., Derhy S., Rougier P., Lenoir C., Attali P., Etienne J. P. A randomized trial of hepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma. J Hepatol. 1990 Sep;11(2):181–184. doi: 10.1016/0168-8278(90)90110-d. [DOI] [PubMed] [Google Scholar]
- Pinna A. D., Iwatsuki S., Lee R. G., Todo S., Madariaga J. R., Marsh J. W., Casavilla A., Dvorchik I., Fung J. J., Starzl T. E. Treatment of fibrolamellar hepatoma with subtotal hepatectomy or transplantation. Hepatology. 1997 Oct;26(4):877–883. doi: 10.1002/hep.510260412. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Polio J., Enriquez R. E., Chow A., Wood W. M., Atterbury C. E. Hepatocellular carcinoma in Wilson's disease. Case report and review of the literature. J Clin Gastroenterol. 1989 Apr;11(2):220–224. doi: 10.1097/00004836-198904000-00022. [DOI] [PubMed] [Google Scholar]
- Riestra S., Rodriguez M., Delgado M., Suárez A., González N., de la Mata M., Diaz G., Miño-Fugarolas G., Rodrigo L. Tamoxifen does not improve survival of patients with advanced hepatocellular carcinoma. J Clin Gastroenterol. 1998 Apr;26(3):200–203. doi: 10.1097/00004836-199804000-00010. [DOI] [PubMed] [Google Scholar]
- Ringe B., Pichlmayr R., Wittekind C., Tusch G. Surgical treatment of hepatocellular carcinoma: experience with liver resection and transplantation in 198 patients. World J Surg. 1991 Mar-Apr;15(2):270–285. doi: 10.1007/BF01659064. [DOI] [PubMed] [Google Scholar]
- Ringe B., Wittekind C., Weimann A., Tusch G., Pichlmayr R. Results of hepatic resection and transplantation for fibrolamellar carcinoma. Surg Gynecol Obstet. 1992 Oct;175(4):299–305. [PubMed] [Google Scholar]
- Rizzi P. M., Kane P. A., Ryder S. D., Ramage J. K., Gane E., Tan K. C., Portmann B., Karani J., Williams R. Accuracy of radiology in detection of hepatocellular carcinoma before liver transplantation. Gastroenterology. 1994 Nov;107(5):1425–1429. doi: 10.1016/0016-5085(94)90545-2. [DOI] [PubMed] [Google Scholar]
- Ryder S. D., Koskinas J., Rizzi P. M., McFarlane I. G., Portmann B. C., Naoumov N. V., Williams R. Hepatocellular carcinoma complicating autoimmune hepatitis: role of hepatitis C virus. Hepatology. 1995 Sep;22(3):718–722. [PubMed] [Google Scholar]
- Ryder S. D., Rizzi P. M., Metivier E., Karani J., Williams R. Chemoembolisation with lipiodol and doxorubicin: applicability in British patients with hepatocellular carcinoma. Gut. 1996 Jan;38(1):125–128. doi: 10.1136/gut.38.1.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saada J., Bhattacharya S., Dhillon A. P., Dick R., Burroughs A. K., Rolles K., Davidson B. R. Detection of small hepatocellular carcinomas in cirrhotic livers using iodised oil computed tomography. Gut. 1997 Sep;41(3):404–407. doi: 10.1136/gut.41.3.404. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sakuma K., Saitoh N., Kasai M., Jitsukawa H., Yoshino I., Yamaguchi M., Nobutomo K., Yamumi M., Tsuda F., Komazawa T. Relative risks of death due to liver disease among Japanese male adults having various statuses for hepatitis B s and e antigen/antibody in serum: a prospective study. Hepatology. 1988 Nov-Dec;8(6):1642–1646. doi: 10.1002/hep.1840080628. [DOI] [PubMed] [Google Scholar]
- Sasaki Y., Imaoka S., Kasugai H., Fujita M., Kawamoto S., Ishiguro S., Kojima J., Ishikawa O., Ohigashi H., Furukawa H. A new approach to chemoembolization therapy for hepatoma using ethiodized oil, cisplatin, and gelatin sponge. Cancer. 1987 Sep 15;60(6):1194–1203. doi: 10.1002/1097-0142(19870915)60:6<1194::aid-cncr2820600607>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
- Schachschal G., Lochs H., Plauth M. Controlled clinical trial of doxorubicin and tamoxifen versus tamoxifen monotherapy in hepatocellular carcinoma. Eur J Gastroenterol Hepatol. 2000 Mar;12(3):281–284. doi: 10.1097/00042737-200012030-00004. [DOI] [PubMed] [Google Scholar]
- Sherman M., Peltekian K. M., Lee C. Screening for hepatocellular carcinoma in chronic carriers of hepatitis B virus: incidence and prevalence of hepatocellular carcinoma in a North American urban population. Hepatology. 1995 Aug;22(2):432–438. [PubMed] [Google Scholar]
- Sheu J. C., Sung J. L., Chen D. S., Lai M. Y., Wang T. H., Yu J. Y., Yang P. M., Chuang C. N., Yang P. C., Lee C. S. Early detection of hepatocellular carcinoma by real-time ultrasonography. A prospective study. Cancer. 1985 Aug 1;56(3):660–666. doi: 10.1002/1097-0142(19850801)56:3<660::aid-cncr2820560338>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
- Sheu J. C., Sung J. L., Chen D. S., Yang P. M., Lai M. Y., Lee C. S., Hsu H. C., Chuang C. N., Yang P. C., Wang T. H. Growth rate of asymptomatic hepatocellular carcinoma and its clinical implications. Gastroenterology. 1985 Aug;89(2):259–266. doi: 10.1016/0016-5085(85)90324-5. [DOI] [PubMed] [Google Scholar]
- Shibata J., Fujiyama S., Sato T., Kishimoto S., Fukushima S., Nakano M. Hepatic arterial injection chemotherapy with cisplatin suspended in an oily lymphographic agent for hepatocellular carcinoma. Cancer. 1989 Oct 15;64(8):1586–1594. doi: 10.1002/1097-0142(19891015)64:8<1586::aid-cncr2820640805>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
- Shibata T., Kojima N., Tabuchi T., Itoh K., Ikai I., Yamaoka Y., Konishi J. Transthoracic percutaneous ethanol injection therapy for hepatocellular carcinomas located beneath the diaphragm. J Vasc Interv Radiol. 1998 Jan-Feb;9(1 Pt 1):97–100. doi: 10.1016/s1051-0443(98)70490-7. [DOI] [PubMed] [Google Scholar]
- Shiratori Y., Shiina S., Imamura M., Kato N., Kanai F., Okudaira T., Teratani T., Tohgo G., Toda N., Ohashi M. Characteristic difference of hepatocellular carcinoma between hepatitis B- and C- viral infection in Japan. Hepatology. 1995 Oct;22(4 Pt 1):1027–1033. doi: 10.1016/0270-9139(95)90605-3. [DOI] [PubMed] [Google Scholar]
- Simonetti R. G., Liberati A., Angiolini C., Pagliaro L. Treatment of hepatocellular carcinoma: a systematic review of randomized controlled trials. Ann Oncol. 1997 Feb;8(2):117–136. doi: 10.1023/a:1008285123736. [DOI] [PubMed] [Google Scholar]
- Solmi L., Primerano A. M., Gandolfi L. Ultrasound follow-up of patients at risk for hepatocellular carcinoma: results of a prospective study on 360 cases. Am J Gastroenterol. 1996 Jun;91(6):1189–1194. [PubMed] [Google Scholar]
- Soreide O., Czerniak A., Bradpiece H., Bloom S., Blumgart L. Characteristics of fibrolamellar hepatocellular carcinoma. A study of nine cases and a review of the literature. Am J Surg. 1986 Apr;151(4):518–523. doi: 10.1016/0002-9610(86)90117-0. [DOI] [PubMed] [Google Scholar]
- Tagger A., Donato F., Ribero M. L., Chiesa R., Portera G., Gelatti U., Albertini A., Fasola M., Boffetta P., Nardi G. Case-control study on hepatitis C virus (HCV) as a risk factor for hepatocellular carcinoma: the role of HCV genotypes and the synergism with hepatitis B virus and alcohol. Brescia HCC Study. Int J Cancer. 1999 May 31;81(5):695–699. doi: 10.1002/(sici)1097-0215(19990531)81:5<695::aid-ijc4>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
- Takayama T., Sekine T., Makuuchi M., Yamasaki S., Kosuge T., Yamamoto J., Shimada K., Sakamoto M., Hirohashi S., Ohashi Y. Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial. Lancet. 2000 Sep 2;356(9232):802–807. doi: 10.1016/S0140-6736(00)02654-4. [DOI] [PubMed] [Google Scholar]
- Taketa K., Endo Y., Sekiya C., Tanikawa K., Koji T., Taga H., Satomura S., Matsuura S., Kawai T., Hirai H. A collaborative study for the evaluation of lectin-reactive alpha-fetoproteins in early detection of hepatocellular carcinoma. Cancer Res. 1993 Nov 15;53(22):5419–5423. [PubMed] [Google Scholar]
- Tan K. C., Rela M., Ryder S. D., Rizzi P. M., Karani J., Portmann B., Heaton N. D., Howard E. R., Williams R. Experience of orthotopic liver transplantation and hepatic resection for hepatocellular carcinoma of less than 8 cm in patients with cirrhosis. Br J Surg. 1995 Feb;82(2):253–256. doi: 10.1002/bjs.1800820239. [DOI] [PubMed] [Google Scholar]
- Tanaka H., Tsukuma H., Kasahara A., Hayashi N., Yoshihara H., Masuzawa M., Kanda T., Kashiwagi T., Inoue A., Kato M. Effect of interferon therapy on the incidence of hepatocellular carcinoma and mortality of patients with chronic hepatitis C: a retrospective cohort study of 738 patients. Int J Cancer. 2000 Sep 1;87(5):741–749. [PubMed] [Google Scholar]
- Tanaka S., Kitamura T., Nakanishi K., Okuda S., Yamazaki H., Hiyama T., Fujimoto I. Effectiveness of periodic checkup by ultrasonography for the early diagnosis of hepatocellular carcinoma. Cancer. 1990 Nov 15;66(10):2210–2214. doi: 10.1002/1097-0142(19901115)66:10<2210::aid-cncr2820661028>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
- Tang Y., Yamashita Y., Arakawa A., Namimoto T., Mitsuzaki K., Abe Y., Katahira K., Takahashi M. Detection of hepatocellular carcinoma arising in cirrhotic livers: comparison of gadolinium- and ferumoxides-enhanced MR imaging. AJR Am J Roentgenol. 1999 Jun;172(6):1547–1554. doi: 10.2214/ajr.172.6.10350287. [DOI] [PubMed] [Google Scholar]
- Taylor-Robinson S. D., Foster G. R., Arora S., Hargreaves S., Thomas H. C. Increase in primary liver cancer in the UK, 1979-94. Lancet. 1997 Oct 18;350(9085):1142–1143. doi: 10.1016/S0140-6736(05)63789-0. [DOI] [PubMed] [Google Scholar]
- Tsukuma H., Hiyama T., Tanaka S., Nakao M., Yabuuchi T., Kitamura T., Nakanishi K., Fujimoto I., Inoue A., Yamazaki H. Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med. 1993 Jun 24;328(25):1797–1801. doi: 10.1056/NEJM199306243282501. [DOI] [PubMed] [Google Scholar]
- Vauthey J. N., Klimstra D., Franceschi D., Tao Y., Fortner J., Blumgart L., Brennan M. Factors affecting long-term outcome after hepatic resection for hepatocellular carcinoma. Am J Surg. 1995 Jan;169(1):28–35. doi: 10.1016/s0002-9610(99)80106-8. [DOI] [PubMed] [Google Scholar]
- Vilana R., Bruix J., Bru C., Ayuso C., Solé M., Rodés J. Tumor size determines the efficacy of percutaneous ethanol injection for the treatment of small hepatocellular carcinoma. Hepatology. 1992 Aug;16(2):353–357. doi: 10.1002/hep.1840160212. [DOI] [PubMed] [Google Scholar]
- Villa E., Dugani A., Fantoni E., Camellini L., Buttafoco P., Grottola A., Pompei G., De Santis M., Ferrari A., Manenti F. Type of estrogen receptor determines response to antiestrogen therapy. Cancer Res. 1996 Sep 1;56(17):3883–3885. [PubMed] [Google Scholar]
- Villa E., Moles A., Ferretti I., Buttafoco P., Grottola A., Del Buono M., De Santis M., Manenti F. Natural history of inoperable hepatocellular carcinoma: estrogen receptors' status in the tumor is the strongest prognostic factor for survival. Hepatology. 2000 Aug;32(2):233–238. doi: 10.1053/jhep.2000.9603. [DOI] [PubMed] [Google Scholar]
- Wood W. J., Rawlings M., Evans H., Lim C. N. Hepatocellular carcinoma: importance of histologic classification as a prognostic factor. Am J Surg. 1988 May;155(5):663–666. doi: 10.1016/s0002-9610(88)80139-9. [DOI] [PubMed] [Google Scholar]
- Yamamoto K., Masuzawa M., Kato M., Kurosawa K., Kaneko A., Ishida H., Imamura E., Park N. J., Shirai Y., Fujimoto K. Evaluation of combined therapy with chemoembolization and ethanol injection for advanced hepatocellular carcinoma. Semin Oncol. 1997 Apr;24(2 Suppl 6):S6–50-S6-55. [PubMed] [Google Scholar]
- Yang Q., McDonnell S. M., Khoury M. J., Cono J., Parrish R. G. Hemochromatosis-associated mortality in the United States from 1979 to 1992: an analysis of Multiple-Cause Mortality Data. Ann Intern Med. 1998 Dec 1;129(11):946–953. doi: 10.7326/0003-4819-129-11_part_2-199812011-00005. [DOI] [PubMed] [Google Scholar]
- Yuen Man-Fung, Poon Ronnie Tung-Ping, Lai Ching-Lung, Fan Sheung-Tat, Lo Chung-Mau, Wong Ka-Wah, Wong Wai Man, Wong Benjamin Chun-Yu. A randomized placebo-controlled study of long-acting octreotide for the treatment of advanced hepatocellular carcinoma. Hepatology. 2002 Sep;36(3):687–691. doi: 10.1053/jhep.2002.35071. [DOI] [PubMed] [Google Scholar]