Table 3.

Randomized Controlled Trials of Cancer Vaccines

Vaccine	Disease	Results
Melanoma vaccine oncosylate[123]	Stage III melanoma	No survival benefit vs control group (live vaccinia virus) at 5 years
Melanoma cell line lysate (Melacine) + low-dose cyclophosphamide[124]	Metastatic melanoma	No survival benefit vs chemotherapy alone
GM2 ganglioside + low-dose cyclophosphamide[125]	Melanoma stage III	Trend toward improved disease-free interval
Autologous colon cancer cells[126]	Stage II/III colon cancer	No survival benefit vs controls
Autologous colon cancer cells[127]	Stage II/III colon cancer	Improvement in disease-free interval, benefit in stage II patients only