Skip to main content
Applied Microbiology logoLink to Applied Microbiology
. 1974 Nov;28(5):840–844. doi: 10.1128/am.28.5.840-844.1974

Toxicity of Short-Chain Fatty Acids and Alcohols Towards Cladosporium resinae

J S Teh 1
PMCID: PMC186835  PMID: 4474832

Abstract

Long-chain saturated fatty acids (C13 to C18) and fatty alcohols (C12 to C18) were well utilized by three different soil isolates of Cladosporium resinae as the sole carbon and energy sources in static liquid cultures. Shorter-chain compounds, down to C5, did not support growth and were in fact toxic towards the fungus growing on glucose. Rapid and considerable potassium efflux, protein leakage, and inhibition of endogenous respiration were observed in the presence of the shorter fatty acids and alcohols. Possible mechanisms and significance of the toxicity are discussed.

Full text

PDF
840

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atlas R. M., Bartha R. Inhibition by fatty acids of the biodegradation of petroleum. Antonie Van Leeuwenhoek. 1973;39(2):257–271. doi: 10.1007/BF02578858. [DOI] [PubMed] [Google Scholar]
  2. Bell G. H. The action of monocarboxylic acids on Candida tropicalis growing on hydrocarbon substrates. Antonie Van Leeuwenhoek. 1971;37(4):385–400. doi: 10.1007/BF02218509. [DOI] [PubMed] [Google Scholar]
  3. Bushnell L. D., Haas H. F. The Utilization of Certain Hydrocarbons by Microorganisms. J Bacteriol. 1941 May;41(5):653–673. doi: 10.1128/jb.41.5.653-673.1941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cofone L., Jr, Walker J. D., Cooney J. J. Utilization of hydrocarbons by Cladosporium resinae. J Gen Microbiol. 1973 May;76(1):243–246. doi: 10.1099/00221287-76-1-243. [DOI] [PubMed] [Google Scholar]
  5. Galbraith H., Miller T. B., Paton A. M., Thompson J. K. Antibacterial activity of long chain fatty acids and the reversal with calcium, magnesium, ergocalciferol and cholesterol. J Appl Bacteriol. 1971 Dec;34(4):803–813. doi: 10.1111/j.1365-2672.1971.tb01019.x. [DOI] [PubMed] [Google Scholar]
  6. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  7. Lambert P. A., Hammond S. M. Potassium fluxes, first indications of membrane damage in micro-organisms. Biochem Biophys Res Commun. 1973 Sep 18;54(2):796–799. doi: 10.1016/0006-291x(73)91494-0. [DOI] [PubMed] [Google Scholar]
  8. NIEMAN C. Influence of trace amounts of fatty acids on the growth of microorganisms. Bacteriol Rev. 1954 Jun;18(2):147–163. doi: 10.1128/br.18.2.147-163.1954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. SAMSON F. E., KATZ A. M., HARRIS D. L. Effects of acetate and other short-chain fatty acids on yeast metabolism. Arch Biochem Biophys. 1955 Feb;54(2):406–423. doi: 10.1016/0003-9861(55)90054-0. [DOI] [PubMed] [Google Scholar]
  10. Teh J. S., Lee K. H. Effects of n-alkanes on Cladosporium resinae. Can J Microbiol. 1974 Jul;20(7):971–976. doi: 10.1139/m74-150. [DOI] [PubMed] [Google Scholar]
  11. Teh J. S., Lee K. H. Utilization of n-alkanes by Cladosporium resinae. Appl Microbiol. 1973 Mar;25(3):454–457. doi: 10.1128/am.25.3.454-457.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. WOELLER F. H. Liquid scintillation counting of C-14-labelled CO2 with phenethylamine. Anal Biochem. 1961 Oct;2:508–511. doi: 10.1016/0003-2697(61)90056-2. [DOI] [PubMed] [Google Scholar]
  13. Walker J. D., Cooney J. J. Oxidation of n-alkanes by Cladosporium resinae. Can J Microbiol. 1973 Oct;19(10):1325–1330. doi: 10.1139/m73-212. [DOI] [PubMed] [Google Scholar]
  14. Walker J. D., Cooney J. J. Pathway of n-alkane oxidation in Cladosporium resinae. J Bacteriol. 1973 Aug;115(2):635–639. doi: 10.1128/jb.115.2.635-639.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Applied Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES