Use of Concentrated Human Serum γ-Globulin in the Prevention and Attenuation of Measles

Charles A Janeway

. 1945 Apr;21(4):202–222.

Use of Concentrated Human Serum γ-Globulin in the Prevention and Attenuation of Measles^*^,^1,2,3

^*

Read October 18, 1944 before the Seventeenth Graduate Fortnight of The New York Academy of Medicine.

Both the clinical studies and the development of the products from blood collected by the American Red Cross have been carried out under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and Harvard University.

The studies reported in this paper would not have been possible without the coöperation of a number of agencies and individuals. Most of the work in Boston in 1943 was carried on by Dr. Charles W. Ordman. Field tests of globulin preparations against measles in 1944 have been carried out with the assistance of the Commission on Measles and Mumps, Board for the Investigation and Control of Influenza and Other Epidemic Diseases in the Army, in Philadelphia and Baltimore under the direction of Drs. Joseph Stokes, Jr., Elizabeth P. Maris and Lt. S. S. Gellis, M.C., A.U.S.; in New York City, through the Department of Health, by Drs. Maurice Greenberg, Samuel Frant and David D. Rutstein; in Washington, D. C., under Capt. L. R. Newhouser, M.C., U.S.N. and Dr. Lewis K. Sweet; in Durham, N. C., under Dr. W. C. Davison; and in Boston and vicinity with the coöperation of the Massachusetts Department of Health, the Massachusetts Antitoxin and Vaccine Laboratory and the Health Officers of Arlington, Medford, Malden and Chelsea. We are indebted to the large number of physicians and hospital staff members in various cities who have provided most of the reports on which this study is based; to Dr. William B. Berenberg and the house and resident staff of the Children's Hospital for their assistance in the control and distribution of globulin; and to Miss Virginia Poole, B.A., who has kept the records, tabulated the data and prepared the charts for this report.

This paper is No. 32 in the series, “Studies on the Plasma Proteins” from the Harvard Medical School, Boston, Massachusetts, on products developed in the Department of Physical Chemistry from blood collected by the American Red Cross.

PMCID: PMC1869384 PMID: 19312433

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Figure 1
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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

Bailey O. T., Ingraham F. D. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XXII. FIBRIN FILMS IN NEUROSURGERY, WITH SPECIAL REFERENCE TO THEIR USE IN THE REPAIR OF DURAL DEFECTS AND IN THE PREVENTION OF MENINGOCEREBRAL ADHESIONS. J Clin Invest. 1944 Jul;23(4):597–600. doi: 10.1172/JCI101529. [DOI] [PMC free article] [PubMed] [Google Scholar]
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Edsall J. T., Ferry R. M., Armstrong S. H. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XV. THE PROTEINS CONCERNED IN THE BLOOD COAGULATION MECHANISM. J Clin Invest. 1944 Jul;23(4):557–565. doi: 10.1172/JCI101522. [DOI] [PMC free article] [PubMed] [Google Scholar]
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Ordman C. W., Jennings C. G., Janeway C. A. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XII. THE USE OF CONCENTRATED NORMAL HUMAN SERUM GAMMA GLOBULIN (HUMAN IMMUNE SERUM GLOBULIN) IN THE PREVENTION AND ATTENUATION OF MEASLES. J Clin Invest. 1944 Jul;23(4):541–549. doi: 10.1172/JCI101519. [DOI] [PMC free article] [PubMed] [Google Scholar]
Scatchard G., Batchelder A. C., Brown A. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. VI. THE OSMOTIC PRESSURE OF PLASMA AND OF SERUM ALBUMIN. J Clin Invest. 1944 Jul;23(4):458–464. doi: 10.1172/JCI101513. [DOI] [PMC free article] [PubMed] [Google Scholar]
Stokes J., Maris E. P., Gellis S. S. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XI. THE USE OF CONCENTRATED NORMAL HUMAN SERUM GAMMA GLOBULIN (HUMAN IMMUNE SERUM GLOBULIN) IN THE PROPHYLAXIS AND TREATMENT OF MEASLES. J Clin Invest. 1944 Jul;23(4):531–540. doi: 10.1172/JCI101518. [DOI] [PMC free article] [PubMed] [Google Scholar]
Warren J. V., Stead E. A., Merrill A. J., Brannon E. S. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. IX. THE TREATMENT OF SHOCK WITH CONCENTRATED HUMAN SERUM ALBUMIN: A PRELIMINARY REPORT. J Clin Invest. 1944 Jul;23(4):506–509. doi: 10.1172/JCI101516. [DOI] [PMC free article] [PubMed] [Google Scholar]
Williams J. W., Petermann M. L., Colovos G. C., Goodloe M. B., Oncley J. L., Armstrong S. H. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. II. ELECTROPHORETIC AND ULTRACENTRIFUGAL STUDIES OF SOLUTIONS OF HUMAN SERUM ALBUMIN AND IMMUNE SERUM GLOBULINS. J Clin Invest. 1944 Jul;23(4):433–436. doi: 10.1172/JCI101509. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01155] Bailey O. T., Ingraham F. D. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XXII. FIBRIN FILMS IN NEUROSURGERY, WITH SPECIAL REFERENCE TO THEIR USE IN THE REPAIR OF DURAL DEFECTS AND IN THE PREVENTION OF MENINGOCEREBRAL ADHESIONS. J Clin Invest. 1944 Jul;23(4):597–600. doi: 10.1172/JCI101529. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01138] Bering E. A. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XX. THE DEVELOPMENT OF FIBRIN FOAM AS A HEMOSTATIC AGENT AND FOR USE IN CONJUNCTION WITH HUMAN THROMBIN. J Clin Invest. 1944 Jul;23(4):586–590. doi: 10.1172/JCI101527. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01056] Cohn E. J., Oncley J. L., Strong L. E., Hughes W. L., Armstrong S. H. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. I. THE CHARACTERIZATION OF THE PROTEIN FRACTIONS OF HUMAN PLASMA. J Clin Invest. 1944 Jul;23(4):417–432. doi: 10.1172/JCI101508. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01082] Cournand A., Noble R. P., Breed E. S., Lauson H. D., Baldwin E. de F., Pinchot G. B., Richards D. W. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. VIII. CLINICAL USE OF CONCENTRATED HUMAN SERUM ALBUMIN IN SHOCK, AND COMPARISON WITH WHOLE BLOOD AND WITH RAPID SALINE INFUSION. J Clin Invest. 1944 Jul;23(4):491–505. doi: 10.1172/JCI101515. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01124] Dees J. E. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XVIII. FIBRINOGEN COAGULUM AS AN AID IN THE OPERATIVE REMOVAL OF RENAL CALCULI. J Clin Invest. 1944 Jul;23(4):576–579. doi: 10.1172/JCI101525. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01171] Degowin E. L. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XIV. APPRAISAL OF ISOHEMAGGLUTININ ACTIVITY. J Clin Invest. 1944 Jul;23(4):554–556. doi: 10.1172/JCI101521. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01101] Edsall J. T., Ferry R. M., Armstrong S. H. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XV. THE PROTEINS CONCERNED IN THE BLOOD COAGULATION MECHANISM. J Clin Invest. 1944 Jul;23(4):557–565. doi: 10.1172/JCI101522. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01197] Enders J. F. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. X. THE CONCENTRATIONS OF CERTAIN ANTIBODIES IN GLOBULIN FRACTIONS DERIVED FROM HUMAN BLOOD PLASMA. J Clin Invest. 1944 Jul;23(4):510–530. doi: 10.1172/JCI101517. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01114] Ferry J. D., Morrison P. R. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XVI. FIBRIN CLOTS, FIBRIN FILMS, AND FIBRINOGEN PLASTICS. J Clin Invest. 1944 Jul;23(4):566–572. doi: 10.1172/JCI101523. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01075] Janeway C. A., Gibson S. T., Woodruff L. M., Heyl J. T., Bailey O. T., Newhouser L. R. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. VII. CONCENTRATED HUMAN SERUM ALBUMIN. J Clin Invest. 1944 Jul;23(4):465–490. doi: 10.1172/JCI101514. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01120] Morrison P. R., Singer M. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XVII. A NOTE ON THE ABSORPTION RATES OF FIBRIN FILMS IN TISSUE. J Clin Invest. 1944 Jul;23(4):573–575. doi: 10.1172/JCI101524. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01243] Ordman C. W., Jennings C. G., Janeway C. A. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XII. THE USE OF CONCENTRATED NORMAL HUMAN SERUM GAMMA GLOBULIN (HUMAN IMMUNE SERUM GLOBULIN) IN THE PREVENTION AND ATTENUATION OF MEASLES. J Clin Invest. 1944 Jul;23(4):541–549. doi: 10.1172/JCI101519. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01063] Scatchard G., Batchelder A. C., Brown A. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. VI. THE OSMOTIC PRESSURE OF PLASMA AND OF SERUM ALBUMIN. J Clin Invest. 1944 Jul;23(4):458–464. doi: 10.1172/JCI101513. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01235] Stokes J., Maris E. P., Gellis S. S. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XI. THE USE OF CONCENTRATED NORMAL HUMAN SERUM GAMMA GLOBULIN (HUMAN IMMUNE SERUM GLOBULIN) IN THE PROPHYLAXIS AND TREATMENT OF MEASLES. J Clin Invest. 1944 Jul;23(4):531–540. doi: 10.1172/JCI101518. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01093] Warren J. V., Stead E. A., Merrill A. J., Brannon E. S. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. IX. THE TREATMENT OF SHOCK WITH CONCENTRATED HUMAN SERUM ALBUMIN: A PRELIMINARY REPORT. J Clin Invest. 1944 Jul;23(4):506–509. doi: 10.1172/JCI101516. [DOI] [PMC free article] [PubMed] [Google Scholar]

[OCR_01176] Williams J. W., Petermann M. L., Colovos G. C., Goodloe M. B., Oncley J. L., Armstrong S. H. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. II. ELECTROPHORETIC AND ULTRACENTRIFUGAL STUDIES OF SOLUTIONS OF HUMAN SERUM ALBUMIN AND IMMUNE SERUM GLOBULINS. J Clin Invest. 1944 Jul;23(4):433–436. doi: 10.1172/JCI101509. [DOI] [PMC free article] [PubMed] [Google Scholar]

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Use of Concentrated Human Serum γ-Globulin in the Prevention and Attenuation of Measles^*^,^1,2,3

Charles A Janeway

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Use of Concentrated Human Serum γ-Globulin in the Prevention and Attenuation of Measles*,1,2,3

Charles A Janeway

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Use of Concentrated Human Serum γ-Globulin in the Prevention and Attenuation of Measles^*^,^1,2,3