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. 1975 May;29(5):641–645. doi: 10.1128/am.29.5.641-645.1975

Egg Production, Shell Thickness, and Other Physiological Parameters of Laying Hens Affected by T-2 Toxin1

R D Wyatt *, J A Doerr *, P B Hamilton *, H R Burmeister *
PMCID: PMC187050  PMID: 1147602

Abstract

T-2 toxin has been reported to cause severe oral lesions and neural disturbances in young broiler chickens. T-2 toxin, when added at a level of 20 μg per g of feed, caused oral lesions but no abnormal neural disturbances in young broiler chickens. T-2 toxin, when added at a level of 20 μg per g of feed, caused oral lesions but no abnormal neural symptoms in laying hens. T-2 toxin had no effect on either hemoglobin, hematocrit values, erythrocyte count, plasma glucose, prothrombin times, or the sizes of the liver, spleen, pancreas, and heart. Lipid content of the liver was not altered. Feed consumption, however, was reduced, as were the total plasma protein and lipid concentrations and the total leukocyte count. Most important economically was the lowered egg production and a thinner egg shell. The timing and severity of the symptoms suggest that T-2 toxin causes primary oral lesions that reduce feed consumption with a consequent reduction in serum proteins and lipids, which culminate in decreased egg production. The leucopenia and thinner egg shell may be independent systemic effects of T-2 toxin in laying hens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bamburg J. R., Riggs N. V., Strong F. M. The structures of toxins from two strains of Fusarium tricinctum. Tetrahedron. 1968 Apr;24(8):3329–3336. doi: 10.1016/s0040-4020(01)92631-6. [DOI] [PubMed] [Google Scholar]
  2. Bitman J., Cecil H. C., Fries G. F. DDT-induced inhibition of avian shell gland carbonic anhydrase: a mechanism for thin eggshells. Science. 1970 May 1;168(3931):594–596. doi: 10.1126/science.168.3931.594. [DOI] [PubMed] [Google Scholar]
  3. Burmeister H. R. T-2 toxin production by Fusarium tricinctum on solid substrate. Appl Microbiol. 1971 Apr;21(4):739–742. doi: 10.1128/am.21.4.739-742.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Christensen C. M., Meronuck R. A., Nelson G. H., Behrens J. C. Effects on turkey poults of rations containing corn invaded by Fusarium tricinctum (Cda.) Sny. & Hans. Appl Microbiol. 1972 Jan;23(1):177–179. doi: 10.1128/am.23.1.177-179.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DUBOWSKI K. M. An o-toluidine method for body-fluid glucose determination. Clin Chem. 1962 May-Jun;8:215–235. [PubMed] [Google Scholar]
  6. Friedman H. S. Quantitative determination of total lipids in serum. Clin Chim Acta. 1968 Feb;19(2):291–295. doi: 10.1016/0009-8981(68)90338-0. [DOI] [PubMed] [Google Scholar]
  7. Gilgan M. W., Smalley E. B., Strong F. M. Isolation and partial characterization of a toxin from Fusarium tricinctum on moldy corn. Arch Biochem Biophys. 1966 Apr;114(1):1–3. doi: 10.1016/0003-9861(66)90297-9. [DOI] [PubMed] [Google Scholar]
  8. Hsu I. C., Smalley E. B., Strong F. M., Ribelin W. E. Identification of T-2 toxin in moldy corn associated with a lethal toxicosis in dairy cattle. Appl Microbiol. 1972 Nov;24(5):684–690. doi: 10.1128/am.24.5.684-690.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kosuri N. R., Smalley E. B., Nichols R. E. Toxicologic studies of Fusarium tricinctum (Corda) Snyder et Hansen from moldy corn. Am J Vet Res. 1971 Nov;32(11):1843–1850. [PubMed] [Google Scholar]
  10. Lehner P. N., Egbert A. Dieldrin and eggshell thickness in ducks. Nature. 1969 Dec 20;224(5225):1218–1219. doi: 10.1038/2241218a0. [DOI] [PubMed] [Google Scholar]
  11. Longcore J. R., Samson F. B., Whittendale T. W., Jr DDE thins eggshells and lowers reproductive success of captive black ducks. Bull Environ Contam Toxicol. 1971 Nov-Dec;6(6):485–490. doi: 10.1007/BF01796852. [DOI] [PubMed] [Google Scholar]
  12. MAYER C. F. Endemic panmyelotoxicosis in the Russian grain belt. I. The clinical aspects of alimentary toxic aleukia (ATA); a comprehensive review. Mil Surg. 1953 Sep;113(3):173–189. [PubMed] [Google Scholar]
  13. MAYER C. F. Endemic panmyelotoxicosis in the Russian grain belt. II. The botany, phytopathology, and toxicology of Russian cereal food. Mil Surg. 1953 Oct;113(4):295–315. [PubMed] [Google Scholar]
  14. Marasas W. F., Bamburg J. R., Smalley E. B., Strong F. M., Ragland W. L., Degurse P. E. Toxic effects on trout, rats, and mice of T-2 toxin produced by the fungus Fusarium tricinctum (Cd.) Snyd. et Hans. Toxicol Appl Pharmacol. 1969 Sep;15(2):471–482. doi: 10.1016/0041-008x(69)90045-3. [DOI] [PubMed] [Google Scholar]
  15. Mirocha C. J., Pathre S. Identification of the toxic principle in a sample of poaefusarin. Appl Microbiol. 1973 Nov;26(5):719–724. doi: 10.1128/am.26.5.719-724.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. SUNDERMAN F. W., MACFATE R. P., MACFADYEN D. A., STEVENSON G. F., COPELAND B. E. Symposium on clinical hemoglobinometry. Am J Clin Pathol. 1953 Jun;23(6):519–598. doi: 10.1093/ajcp/23.6.519. [DOI] [PubMed] [Google Scholar]
  17. Smith J. W., Hamilton P. B. Aflatoxicosis in the broiler chicken. Poult Sci. 1970 Jan;49(1):207–215. doi: 10.3382/ps.0490207. [DOI] [PubMed] [Google Scholar]
  18. Ueno Y., Ishii K., Sakai K., Kanaeda S., Tsunoda H. Toxicological approaches to the metabolites of Fusaria. IV. Microbial survey on "bean-hulls poisoning of horses" with the isolation of toxic trichothecenes, neosolaniol and T-2 toxin of Fusarium solani M-1-1. Jpn J Exp Med. 1972 Jun;42(3):187–203. [PubMed] [Google Scholar]
  19. Ueno Y., Sato N., Ishii K., Sakai K., Tsunoda H. Biological and chemical detection of trichothecene mycotoxins of Fusarium species. Appl Microbiol. 1973 Apr;25(4):699–704. doi: 10.1128/am.25.4.699-704.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wyatt R. D., Colwell W. M., Hamilton P. B., Burmeister H. R. Neural disturbances in chickens caused by dietary T-2 toxin. Appl Microbiol. 1973 Nov;26(5):757–761. doi: 10.1128/am.26.5.757-761.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Wyatt R. D., Harris J. R., Hamilton P. B., Burmeister H. R. Possible outbreaks of fusariotoxicosis in avians. Avian Dis. 1972 Oct-Dec;16(5):1123–1130. [PubMed] [Google Scholar]
  22. Wyatt R. D., Weeks B. A., Hamilton P. B., Burmeister H. R. Severe oral lesions in chickens caused by ingestion of dietary fusariotoxin T-2. Appl Microbiol. 1972 Aug;24(2):251–257. doi: 10.1128/am.24.2.251-257.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]

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