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. 1975 Jul;30(1):48–51. doi: 10.1128/am.30.1.48-51.1975

Nephrotoxicity of Dietary Ochratoxin A in Broiler Chikens1

W E Huff *, R D Wyatt *, P B Hamilton *
PMCID: PMC187112  PMID: 1147620

Abstract

Graded doses of pure ochratoxin A (0, 0.5, 1.0, 2.0, 4.0, and 8.0 μg of toxin per g of feed) were incorporated into a commercial diet which was fed to chicks from 1 day to 3 weeks of age, at which time the experiments were terminated. Growth was inhibited at 2.0, 4.0, and 8.0 μg/g, whereas the kidneys were enlarged at doses of 1.0 μg/g and above. Renal function as measured by clearance of phenol red was decreased 15 and 31% by doses of 4.0 and 8.0 μg/g, respectively. Uric acid was increased 38 and 48% over the control values by doses of 4.0 and 8.0 μg/g, respectively. The plasma electrolytes Na, Cl, Ca, and K were measured; however, only K was significantly (P < 0.05) altered, showing a decrease at doses of 4.0 and 8.0 μg/g. The percentage dry weight of the kidneys decreased significantly at dose levels of 4.0 and 8.0 μg/g, indicative of edema. Histological examination of kidney sections gave the impression of edema and some tubular necrosis. Pathological changes were observed at all dose levels. These data demonstrate that ochratoxin A is a severe nephrotoxin in young broiler chickens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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