Skip to main content
PMC home page
Applied Microbiology logoLink to Applied Microbiology
. 1975 Aug;30(2):262–266. doi: 10.1128/am.30.2.262-266.1975

Transformation of Morphine by Resting Cells and Cell-Free Systems of Arthrobacter Sp

Paloma Liras 1, W W Umbreit 1
PMCID: PMC187164  PMID: 240309

Abstract

Morphine can be transformed into 14-hydroxymorphine and a related unidentified material by resting cells of an Arthrobacter species. Cell-free extracts containing the transforming enzyme(s) have been obtained. O2, Fe2+, and reduced nicotinamide adenine dinucleotide stimulate the transformation.

Full text

PDF
262

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aida K., Uchida K., Iizuka K., Okuda S., Tsuda K., Uemura T. Incorporation of molecular oxygen into a morphine alkaloid, 14-hydroxycodeinone by Trametes sanguinea. Biochem Biophys Res Commun. 1966 Jan 4;22(1):13–16. doi: 10.1016/0006-291x(66)90594-8. [DOI] [PubMed] [Google Scholar]
  2. HARTMAN R. E., KRAUSE E. F., ANDRES W. W., PATTERSON E. L. MICROBIAL HYDROXYLATION OF INDOLE ALKALOIDS. Appl Microbiol. 1964 Mar;12:138–140. doi: 10.1128/am.12.2.138-140.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HOCHSTEIN L. I., RITTENBERG S. C. The bacterial oxidation of nicotine. I. Nicotine oxidation by cell-free preparations. J Biol Chem. 1959 Jan;234(1):151–155. [PubMed] [Google Scholar]
  4. Katagiri M., Ganguli B. N., Gunsalus I. C. A soluble cytochrome P-450 functional in methylene hydroxylation. J Biol Chem. 1968 Jun 25;243(12):3543–3546. [PubMed] [Google Scholar]
  5. Peterson J. A., Basu D., Coon M. J. Enzymatic omega-oxidation. I. Electon carriers in fatty acid and hydrocarbon hydroxylation. J Biol Chem. 1966 Nov 10;241(21):5162–5164. [PubMed] [Google Scholar]
  6. Ruettinger R. T., Olson S. T., Boyer R. F., Coon M. J. Identification of the omega-hydroxylase of Pseudomonas oleovorans as a nonheme iron protein requiring phospholipid for catalytic activity. Biochem Biophys Res Commun. 1974 Apr 23;57(4):1011–1017. doi: 10.1016/0006-291x(74)90797-9. [DOI] [PubMed] [Google Scholar]
  7. SMITH C. G., JOHNSON M. J. Aeration requirements for the growth of aerobic microorganisms. J Bacteriol. 1954 Sep;68(3):346–350. doi: 10.1128/jb.68.3.346-350.1954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. WILSON J. E., VESTLING C. S. A CELL-FREE STEROID HYDROXYLATING SYSTEM FROM BACILLUS MEGATERIUM, STRAIN KM. Arch Biochem Biophys. 1965 May;110:401–403. doi: 10.1016/0003-9861(65)90141-4. [DOI] [PubMed] [Google Scholar]

Articles from Applied Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES