Table 3.
Multicovariate analysis of 92714C>G (D1241E) and FVIII:C levels in the GAIT population
| Covariate* | Model 1 |
Model 2 |
Model 3 |
Model 4 |
||||
|---|---|---|---|---|---|---|---|---|
| β† | P‡ | β† | P‡ | β† | P‡ | β† | P‡ | |
| Age, y | −4.12 | .089 | −3.43 | .178 | −3.75 | .065 | −3.33 | .090 |
| Sex | 4.43 | .364 | 6.45 | .187 | 13.72 | .001 | 13.41 | .001 |
| Age × sex | −1.33 | .729 | −4.93 | .250 | −3.37 | .322 | −3.73 | .257 |
| A15§ | 3.62 | .152 | 3.00 | .258 | 3.44 | .102 | 3.03 | .136 |
| A15 × sex | 2.12 | .596 | 5.62 | .206 | 3.88 | .272 | 4.14 | .225 |
| A50§ | 3.48 | < .001 | 3.13 | < .001 | 1.44 | .013 | 1.58 | .005 |
| A50 × sex | −2.78 | .004 | −2.30 | .015 | −1.48 | .058 | −1.42 | .059 |
| OC status‖ | −23.82 | .056 | −23.80 | .080 | −11.22 | .298 | −15.10 | .148 |
| Smoking status‖ | −11.45 | .021 | −13.48 | .008 | −5.84 | .153 | −8.27 | .038 |
| AA¶ | 25.85 | .002 | 27.61 | .001 | 10.36 | .135 | 11.47 | .084 |
| AB¶ | 26.03 | .109 | 35.41 | .047 | 11.23 | .444 | 9.91 | .482 |
| AO¶ | 21.80 | < .001 | 15.78 | .006 | 3.75 | .447 | 2.71 | .568 |
| BO¶ | 26.91 | .002 | 29.53 | .001 | 15.56 | .032 | 16.97 | .015 |
| DM status‖ | −6.11 | .618 | −25.36 | .101 | −4.01 | .746 | −9.45 | .470 |
| Fibrinogen level, IU dL−1 | 13.56 | < .001 | 9.17 | .012 | 2.55 | .400 | 0.37 | .901 |
| BMI, kg m−2 | 0.22 | .718 | −0.46 | .471 | 0.85 | .085 | −0.05 | .926 |
| VLDL level, mM | 45.58 | < .001 | 22.49 | .082 | 21.12 | .039 | 8.60 | .398 |
| FIX:C level, IU dL−1 | N/A | N/A | 0.56 | < .001 | N/A | N/A | 0.45 | < .001 |
| VWF:Ag level, IU dL−1 | N/A | N/A | N/A | N/A | 0.73 | < .001 | 0.66 | < .001 |
| D1241E# | 14.33 | .016 | 11.99 | .049 | 7.26 | .142 | 6.10 | .199 |
For model 1, n = 361; for model 2, n = 313; for model 3, n = 307; for model 4, n = 306.
Endogenous, environmental, and genetic variables included in the marginal measured-genotype association analysis of the relationship between D1241E and FVIII:C levels in GAIT.
The estimated effect (β) of a given covariate or each D-allele of the FVIII D1241E polymorphism (F8 92714C>G) on FVIII:C levels.
The P value for each β.
The coefficient for splines with knots at 15 and 50 years.
Status (yes/no) indicates either any use (smoking and oral contraception) or the presence of diagnostic criteria for DM.
The 4 ABO genotypes, other than OO (reference genotype), found in GAIT subjects.
D1241E genotypes were grouped and represented with indicator variables as follows: 1 (D/D and D/Y); 0 (D/d); and −1 (d/d and d/Y).