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. 1983 Feb 1;128(3):257–260.

The pathogenesis of neuropsychiatric lupus

Judah A Denburg, Peter Temesvari
PMCID: PMC1874798  PMID: 6295587

Abstract

Neuropsychiatric lupus is a frequent and serious complication of systemic lupus erythematosus. Although its pathogenesis has not been fully elucidated several mechanisms based on findings in animals and humans have been proposed: cerebral vasculitis; the cross-reaction of lymphocytotoxic antibodies with brain tissue; choroid plexus dysfunction; and the blocking of neurotransmission by noncytotoxic antibodies. Any or all of these mechanisms may be active in a particular patient at a given time.

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Selected References

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