Skip to main content
NCBI home page
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1983 Mar 1;128(5):545–549.

Normal urate transport into erythrocytes in familial renal hypouricemia and in the Dalmatian dog.

P Vinay, A Gattereau, B Moulin, A Gougoux, G Lemieux
PMCID: PMC1874992  PMID: 6825020

Abstract

It has been hypothesized that humans with familial renal hypouricemia may have a generalized defect of urate transport across cell membranes due to the genetic deletion of a specific carrier, a defect similar to that reported in the Dalmatian dog. In this study the transport of urate labelled with carbon 14 by the erythrocytes of four patients with familial renal hypouricemia was identical to that of five healthy controls. The addition of hypoxanthine to the incubation medium inhibited the transport to a similar extent in the two groups of patients, demonstrating the presence of a carrier specific for urate. This carrier was also found to be present in the erythrocytes of Dalmatian and mongrel dogs. Thus, the renal anomaly causing the hypouricemia in both species is not related to a generalized deletion of a urate-transporting protein on cell membranes.

Full text

PDF
545

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akaoka I., Nishizawa T., Yano E., Kamtani N., Nishida Y., Sasaki S. Renal urate excretion in five cases of hypouricemia with an isolated renal defect of urate transport. J Rheumatol. 1977 Spring;4(1):86–94. [PubMed] [Google Scholar]
  2. Al-Jurf A., Steiger E. Hypouricemia in total parenteral nutrition. Am J Clin Nutr. 1980 Dec;33(12):2630–2634. doi: 10.1093/ajcn/33.12.2630. [DOI] [PubMed] [Google Scholar]
  3. Beck L. H. Hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone. N Engl J Med. 1979 Sep 6;301(10):528–530. doi: 10.1056/NEJM197909063011005. [DOI] [PubMed] [Google Scholar]
  4. Benjamin D., Sperling O., Weinberger A., Pinkhas J., de Vries A. Familial hypouricemia due to isolated renal tubular defect. Attenuated response of uric acid clearance to probenecid and pyrazinamide. Nephron. 1977;18(4):220–225. doi: 10.1159/000180832. [DOI] [PubMed] [Google Scholar]
  5. Bennett J. S., Bond J., Singer I., Gottlieb A. J. Hypouricemia in Hodgkin's disease. Ann Intern Med. 1972 May;76(5):751–756. doi: 10.7326/0003-4819-76-5-751. [DOI] [PubMed] [Google Scholar]
  6. Cooper D. S. Oat-cell carcinoma and severe hypouricemia. N Engl J Med. 1973 Feb 8;288(6):321–322. doi: 10.1056/NEJM197302082880616. [DOI] [PubMed] [Google Scholar]
  7. Delevelle F., Trombert J. C., Bouvier M. F., Canarelli G. Hypouricémie rénale idiopathique. 1 observation. Nouv Presse Med. 1980 Sep 27;9(35):2578–2578. [PubMed] [Google Scholar]
  8. Dwosh I. L., Roncari D. A., Marliss E., Fox I. H. Hypouricemia in disease: a study of different mechanisms. J Lab Clin Med. 1977 Jul;90(1):153–161. [PubMed] [Google Scholar]
  9. Fujiwara Y., Takamitsu Y., Ueda N., Orita Y., Abe H. Hypouricemia due to an isolated defect in renal tubular urate reabsorption. Clin Nephrol. 1980 Jan;13(1):44–48. [PubMed] [Google Scholar]
  10. Greene M. L., Marcus R., Aurbach G. D., Kazam E. S., Seegmiller J. E. Hypouricemia due to isolated renal tubular defect. Dalmatian dog mutation in man. Am J Med. 1972 Sep;53(3):361–367. doi: 10.1016/0002-9343(72)90181-7. [DOI] [PubMed] [Google Scholar]
  11. HARVEY A. M., CHRISTENSEN H. N. URIC ACID TRANSPORT SYSTEM: APPARENT ABSENCE IN ERYTHROCYTES OF THE DALMATIAN COACH HOUND. Science. 1964 Aug 21;145(3634):826–827. doi: 10.1126/science.145.3634.826. [DOI] [PubMed] [Google Scholar]
  12. Healey L. A., Skeith M. D., Simkin P. A. Hypouricemia. An incidental finding indicating xanthinuria or defective reabsorption of uric acid. Arch Intern Med. 1974 Jul;134(1):46–47. doi: 10.1001/archinte.134.1.46. [DOI] [PubMed] [Google Scholar]
  13. Kawabe K., Murayama T., Akaoka I. A case of uric acid renal stone with hypouricemia caused by tubular reabsorptive defect of uric acid. J Urol. 1976 Dec;116(6):690–692. doi: 10.1016/s0022-5347(17)58973-9. [DOI] [PubMed] [Google Scholar]
  14. Kay N. E., Gottlieb A. J. Hypouricemia in Hodgkin's disease. Report of an additional case. Cancer. 1973 Dec;32(6):1508–1511. doi: 10.1002/1097-0142(197312)32:6<1508::aid-cncr2820320630>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  15. Kelley W. N. Hypouricemia. Arthritis Rheum. 1975 Nov-Dec;18(6 Suppl):731–737. doi: 10.1002/art.1780180715. [DOI] [PubMed] [Google Scholar]
  16. Khachadurian A. K., Arslanian M. J. Hypouricemia due to renal uricosuria. A case study. Ann Intern Med. 1973 Apr;78(4):547–550. doi: 10.7326/0003-4819-78-4-547. [DOI] [PubMed] [Google Scholar]
  17. Kuster G., Shorter R. G., Dawson B., Hallenbeck G. A. Uric acid metabolism in dalmatians and other dogs. Role of the liver. Arch Intern Med. 1972 Mar;129(3):492–496. [PubMed] [Google Scholar]
  18. Matz R., Christodoulou J., Vianna N., Ruwitch J. Renal tubular dysfunction associated with alcoholism and liver disease. N Y State J Med. 1969 May 15;69(10):1312–1314. [PubMed] [Google Scholar]
  19. Michelis M. F., Warms P. C., Fusco R. D., Davis B. B. Hypouricemia and hyperuricosuria in Laennec cirrhosis. Arch Intern Med. 1974 Oct;134(4):681–683. [PubMed] [Google Scholar]
  20. Mir M. A. Renal excretion of uric acid and its relation to relapse and remission in acute myeloid leukaemia. Nephron. 1977;19(2):69–80. doi: 10.1159/000180868. [DOI] [PubMed] [Google Scholar]
  21. OVERGAARD-HANSEN K., LASSEN U. V. Active transport of uric acid through the human erythrocyte membrane. Nature. 1959 Aug 15;184(Suppl 8):553–554. doi: 10.1038/184553b0. [DOI] [PubMed] [Google Scholar]
  22. PRAETORIUS E., KIRK J. E. Hypouricemia: with evidence for tubular elimination of uric acid. J Lab Clin Med. 1950 Jun;35(6):865–868. [PubMed] [Google Scholar]
  23. Ramsdell C. M., Kelley W. N. The clinical significance of hypouricemia. Ann Intern Med. 1973 Feb;78(2):239–242. doi: 10.7326/0003-4819-78-2-239. [DOI] [PubMed] [Google Scholar]
  24. Roch-Ramel F., Wong N. L., Dirks J. H. Renal excretion of urate in mongrel and Dalmatian dogs: a micropuncture study. Am J Physiol. 1976 Aug;231(2):326–331. doi: 10.1152/ajplegacy.1976.231.2.326. [DOI] [PubMed] [Google Scholar]
  25. Rosner I. A., Askari A. D., McLaren G. D., Muir A. Arthropathy, hypouricemia and normal serum iron studies in hereditary hemochromatosis. Am J Med. 1981 Apr;70(4):870–874. doi: 10.1016/0002-9343(81)90546-5. [DOI] [PubMed] [Google Scholar]
  26. Schlosstein L., Kippen I., Bluestone R., Whitehouse M. W., Klinenberg J. R. Association between hypouricaemia and jaundice. Ann Rheum Dis. 1974 Jul;33(4):308–312. doi: 10.1136/ard.33.4.308. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Sperling O., Boer P., Weinberger A., de Vries A. Transport into erythrocytes and intestinal absorption of uric acid in hereditary renal hypouricemia. Biomedicine. 1975 Jun 10;23(5):157–159. [PubMed] [Google Scholar]
  28. Sperling O., Weinberger A., Oliver I., Liberman U. A., De Vries A. Hypouricemia, hypercalciuria, and decreased bone density: a hereditary syndrome. Ann Intern Med. 1974 Apr;80(4):482–487. doi: 10.7326/0003-4819-80-4-482. [DOI] [PubMed] [Google Scholar]
  29. WEINSTEIN B., IRREVERRE F., WATKIN D. M. LUNG CARCINOMA, HYPOURICEMIA AND AMINOACIDURIA. Am J Med. 1965 Sep;39:520–526. doi: 10.1016/0002-9343(65)90219-6. [DOI] [PubMed] [Google Scholar]
  30. Weinman E. J., Eknoyan G., Suki W. N. The influence of the extracellular fluid volume on the tubular reabsorption of uric acid. J Clin Invest. 1975 Feb;55(2):283–291. doi: 10.1172/JCI107931. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Weitz R., Sperling O. Hereditary renal hypouricemia. Isolated tubular defect of urate reabsorption. J Pediatr. 1980 May;96(5):850–853. doi: 10.1016/s0022-3476(80)80555-5. [DOI] [PubMed] [Google Scholar]
  32. Wilson D. M., Goldstein N. P. Renal urate excretion in patients with Wilson's disease. Kidney Int. 1973 Nov;4(5):331–336. doi: 10.1038/ki.1973.125. [DOI] [PubMed] [Google Scholar]
  33. YU T. F., BERGER L., GUTMAN A. B. Suppression of tubular secretion of urate by pyrazinamide in the dog. Proc Soc Exp Biol Med. 1961 Aug-Sep;107:905–908. doi: 10.3181/00379727-107-26790. [DOI] [PubMed] [Google Scholar]
  34. YU T. F., BERGER L., KUPFER S., GUTMAN A. B. Tubular secretion of urate in the dog. Am J Physiol. 1960 Dec;199:1199–1204. doi: 10.1152/ajplegacy.1960.199.6.1199. [DOI] [PubMed] [Google Scholar]
  35. Yü T. F., Gutman A. B., Berger L., Kaung C. Low uricase activity in the Dalmatian dog simulated in mongrels given oxonic acid. Am J Physiol. 1971 Apr;220(4):973–979. doi: 10.1152/ajplegacy.1971.220.4.973. [DOI] [PubMed] [Google Scholar]
  36. Zamkoff K., Kaplan M., Gottlieb A. J. Hypouricemia in Hodgkin's disease. Relation to extent of disease. N Y State J Med. 1978 Jun;78(7):1047–1049. [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES