Abstract
Devil's Claw (Harpagophytum procumbens), an herbal product being marketed in Canada as a home remedy for the relief of arthritic disease, was screened for efficacy with standard preclinical screening methods. At doses 100 times or greater than the recommended daily dose for humans, Devil's Claw was completely ineffective in reducing edema of the rat hind foot induced by either lambda-carrageenan or Mycobacterium butyricum. At concentrations of up to 1 x 10(5) microgram/ml, Devil's Claw was also ineffective as an in-vitro inhibitor of prostaglandin synthetase. These results indicate that Devil's Claw lacks the anti-inflammatory properties possessed by all antiarthritic drugs of the nonsteroidal, anti-inflammatory analgesic type.
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Selected References
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- Caprasse M. Description, identification et usages thérapeutiques de la "griffe du diable": Harpagophytum procumbens DC. J Pharm Belg. 1980 Mar-Apr;35(2):143–149. [PubMed] [Google Scholar]
- Grahame R., Robinson B. V. Devils's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis. 1981 Dec;40(6):632–632. doi: 10.1136/ard.40.6.632. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McLeod D. W., Revell P., Robinson B. V. Investigations of Harpagophytum procumbens (Devil's Claw) in the treatment of experimental inflammation and arthritis in the rat [proceedings]. Br J Pharmacol. 1979 May;66(1):140P–141P. [PMC free article] [PubMed] [Google Scholar]
- WINTER C. A., RISLEY E. A., NUSS G. W. Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc Soc Exp Biol Med. 1962 Dec;111:544–547. doi: 10.3181/00379727-111-27849. [DOI] [PubMed] [Google Scholar]
- Waud D. R. On biological assays involving quantal responses. J Pharmacol Exp Ther. 1972 Dec;183(3):577–607. [PubMed] [Google Scholar]
- Yanagi Y., Komatsu T. Inhibition of prostaglandin biosynthesis by SL-573. Biochem Pharmacol. 1976 Apr 15;25(8):937–941. doi: 10.1016/0006-2952(76)90319-1. [DOI] [PubMed] [Google Scholar]
- Yoshimoto A., Ito H., Tomita K. Cofactor requirements of the enzyme synthesizing prostagland in bovine seminal vesicles. J Biochem. 1970 Oct;68(4):487–499. doi: 10.1093/oxfordjournals.jbchem.a129379. [DOI] [PubMed] [Google Scholar]