Skip to main content
Canadian Medical Association Journal logoLink to Canadian Medical Association Journal
. 1983 Sep 1;129(5):454–457.

Drug resistance in malaria: three cases and a review.

J L Isaac-Renton, A L Koon, R M Chan, A W Chow, S L Sacks
PMCID: PMC1875151  PMID: 6349767

Abstract

Drug resistance has been well documented in two species of malarial parasites. Of greatest concern are the rapid developments in the resistance of Plasmodium falciparum to commonly used therapeutic and chemoprophylactic agents. This species, which is capable of producing life-threatening disease, has shown various levels of resistance in different parts of the world. Also, some strains of the most common species causing relapsing disease, P. vivax, exhibit resistance to primaquine. Three cases of malaria that demonstrate various types of drug resistance are presented in this paper.

Full text

PDF
454

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brockelman C. R., Monkolkeha S., Tanariya P. Decrease in susceptibility of Plasmodium falciparum to mefloquine in continuous culture. Bull World Health Organ. 1981;59(2):249–252. [PMC free article] [PubMed] [Google Scholar]
  2. Campbell C. C., Chin W., Collins W. E., Teutsch S. M., Moss D. M. Chloroquine-resistant Plasmodium falciparum from East Africa: cultivation and drug sensitivity of the Tanzanian I/CDC strain from an American tourist. Lancet. 1979 Dec 1;2(8153):1151–1154. doi: 10.1016/s0140-6736(79)92383-3. [DOI] [PubMed] [Google Scholar]
  3. Drugs for parasitic infections. Med Lett Drugs Ther. 1982 Jan 22;24(601):5–12. [PubMed] [Google Scholar]
  4. Jiang J. B., Li G. Q., Guo X. B., Kong Y. C., Arnold K. Antimalarial activity of mefloquine and qinghaosu. Lancet. 1982 Aug 7;2(8293):285–288. doi: 10.1016/s0140-6736(82)90268-9. [DOI] [PubMed] [Google Scholar]
  5. Reacher M., Campbell C. C., Freeman J., Doberstyn E. B., Brandling-Bennett A. D. Drug therapy for Plasmodium falciparum malaria resistant to pyrimethamine-sulfadoxine (Fansidar). A study of alternate regimens in Eastern Thailand, 1980. Lancet. 1981 Nov 14;2(8255):1066–1069. doi: 10.1016/s0140-6736(81)91274-5. [DOI] [PubMed] [Google Scholar]

Articles from Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association

RESOURCES