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. 1984 Apr 1;130(7):894–896.

High-dose intravenous therapy with immune globulin before delivery for idiopathic thrombocytopenic purpura.

R J Adderley, P C Rogers, D Shaw, L D Wadsworth
PMCID: PMC1875992  PMID: 6423252

Abstract

A 15-year-old girl with a 9-year history of idiopathic thrombocytopenic purpura resistant to high-dose steroid therapy and to splenectomy was admitted to hospital at 35 weeks' gestation with a platelet count of 10 X 10(9)/L. The bleeding time was normal, and measures of platelet aggregation were nearly so. Treatment with high intravenous doses of polyvalent immune globulin led to a rise in the platelet count to more than 110 X 10(9)/L within 5 days. An elective cesarean section was performed through the lower uterine segment with good hemostasis. After delivery the platelet count fell to its former level, but no postpartum bleeding occurred. There was a brief episode of thrombocytopenia in the infant, with some petechiae but no other hemorrhagic manifestations. No untoward effects of the immune globulin infusion were observed in either mother or daughter.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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