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. 1993 Jan;37(1):144–147. doi: 10.1128/aac.37.1.144

Evaluation of synergy between carbovir and 3'-azido-2',3'-deoxythymidine for inhibition of human immunodeficiency virus type 1.

M S Smith 1, J A Kessler 1, C D Rankin 1, J S Pagano 1, J Kurtzberg 1, S G Carter 1
PMCID: PMC187624  PMID: 8431013

Abstract

3'-Azido-2',3'-deoxythymidine and carbovir [racemic and (-) enantiomer] were evaluated individually and in combination for antiviral activity against human immunodeficiency virus type 1 replication and cytotoxicity in vitro. The combination of these drugs synergistically inhibited human immunodeficiency virus type 1 replication in C3 and Jurkat cells and in human peripheral blood mononuclear cells, although the same combination also produced synergistic cytotoxicity in human peripheral blood mononuclear cells.

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Selected References

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