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. 2004 Dec;90(Suppl 6):vi2–vi4. doi: 10.1136/hrt.2004.048546

Cardiac resynchronisation therapy: when the drugs don't work.

R Bleasdale, M Frenneaux
PMCID: PMC1876330  PMID: 15564421

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Selected References

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  1. Aaronson K. D., Schwartz J. S., Chen T. M., Wong K. L., Goin J. E., Mancini D. M. Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation. Circulation. 1997 Jun 17;95(12):2660–2667. doi: 10.1161/01.cir.95.12.2660. [DOI] [PubMed] [Google Scholar]
  2. Abraham William T., Fisher Westby G., Smith Andrew L., Delurgio David B., Leon Angel R., Loh Evan, Kocovic Dusan Z., Packer Milton, Clavell Alfredo L., Hayes David L. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002 Jun 13;346(24):1845–1853. doi: 10.1056/NEJMoa013168. [DOI] [PubMed] [Google Scholar]
  3. Atherton J. J., Moore T. D., Lele S. S., Thomson H. L., Galbraith A. J., Belenkie I., Tyberg J. V., Frenneaux M. P. Diastolic ventricular interaction in chronic heart failure. Lancet. 1997 Jun 14;349(9067):1720–1724. doi: 10.1016/S0140-6736(96)05109-4. [DOI] [PubMed] [Google Scholar]
  4. Blanc J. J., Etienne Y., Gilard M., Mansourati J., Munier S., Boschat J., Benditt D. G., Lurie K. G. Evaluation of different ventricular pacing sites in patients with severe heart failure: results of an acute hemodynamic study. Circulation. 1997 Nov 18;96(10):3273–3277. doi: 10.1161/01.cir.96.10.3273. [DOI] [PubMed] [Google Scholar]
  5. Bleasdale R. A., Turner M. S., Mumford C. E., Steendijk P., Paul V., Tyberg J. V., Morris-Thurgood J. A., Frenneaux M. P. Left ventricular pacing minimizes diastolic ventricular interaction, allowing improved preload-dependent systolic performance. Circulation. 2004 Oct 11;110(16):2395–2400. doi: 10.1161/01.CIR.0000145169.82004.CF. [DOI] [PubMed] [Google Scholar]
  6. Brecker S. J., Xiao H. B., Sparrow J., Gibson D. G. Effects of dual-chamber pacing with short atrioventricular delay in dilated cardiomyopathy. Lancet. 1992 Nov 28;340(8831):1308–1312. doi: 10.1016/0140-6736(92)92492-x. [DOI] [PubMed] [Google Scholar]
  7. Breithardt Ole A., Sinha Anil M., Schwammenthal Ehud, Bidaoui Nadim, Markus Kai U., Franke Andreas, Stellbrink Christoph. Acute effects of cardiac resynchronization therapy on functional mitral regurgitation in advanced systolic heart failure. J Am Coll Cardiol. 2003 Mar 5;41(5):765–770. doi: 10.1016/s0735-1097(02)02937-6. [DOI] [PubMed] [Google Scholar]
  8. Bristow Michael R., Saxon Leslie A., Boehmer John, Krueger Steven, Kass David A., De Marco Teresa, Carson Peter, DiCarlo Lorenzo, DeMets David, White Bill G. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med. 2004 May 20;350(21):2140–2150. doi: 10.1056/NEJMoa032423. [DOI] [PubMed] [Google Scholar]
  9. Cazeau S., Leclercq C., Lavergne T., Walker S., Varma C., Linde C., Garrigue S., Kappenberger L., Haywood G. A., Santini M. Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay. N Engl J Med. 2001 Mar 22;344(12):873–880. doi: 10.1056/NEJM200103223441202. [DOI] [PubMed] [Google Scholar]
  10. Cazeau S., Ritter P., Lazarus A., Gras D., Backdach H., Mundler O., Mugica J. Multisite pacing for end-stage heart failure: early experience. Pacing Clin Electrophysiol. 1996 Nov;19(11 Pt 2):1748–1757. doi: 10.1111/j.1540-8159.1996.tb03218.x. [DOI] [PubMed] [Google Scholar]
  11. Cowell R., Morris-Thurgood J., Ilsley C., Paul V. Septal short atrioventricular delay pacing: additional hemodynamic improvements in heart failure. Pacing Clin Electrophysiol. 1994 Nov;17(11 Pt 2):1980–1983. doi: 10.1111/j.1540-8159.1994.tb03784.x. [DOI] [PubMed] [Google Scholar]
  12. Cowie M. R., Mosterd A., Wood D. A., Deckers J. W., Poole-Wilson P. A., Sutton G. C., Grobbee D. E. The epidemiology of heart failure. Eur Heart J. 1997 Feb;18(2):208–225. doi: 10.1093/oxfordjournals.eurheartj.a015223. [DOI] [PubMed] [Google Scholar]
  13. Dauterman K., Pak P. H., Maughan W. L., Nussbacher A., Ariê S., Liu C. P., Kass D. A. Contribution of external forces to left ventricular diastolic pressure. Implications for the clinical use of the Starling law. Ann Intern Med. 1995 May 15;122(10):737–742. doi: 10.7326/0003-4819-122-10-199505150-00001. [DOI] [PubMed] [Google Scholar]
  14. Gold M. R., Feliciano Z., Gottlieb S. S., Fisher M. L. Dual-chamber pacing with a short atrioventricular delay in congestive heart failure: a randomized study. J Am Coll Cardiol. 1995 Oct;26(4):967–973. doi: 10.1016/0735-1097(95)00292-0. [DOI] [PubMed] [Google Scholar]
  15. Gregoratos Gabriel, Abrams Jonathan, Epstein Andrew E., Freedman Roger A., Hayes David L., Hlatky Mark A., Kerber Richard E., Naccarelli Gerald V., Schoenfeld Mark H., Silka Michael J. ACC/AHA/NASPE 2002 guideline update for implantation of cardiac pacemakers and antiarrhythmia devices: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/NASPE Committee to Update the 1998 Pacemaker Guidelines). Circulation. 2002 Oct 15;106(16):2145–2161. doi: 10.1161/01.cir.0000035996.46455.09. [DOI] [PubMed] [Google Scholar]
  16. Grines C. L., Bashore T. M., Boudoulas H., Olson S., Shafer P., Wooley C. F. Functional abnormalities in isolated left bundle branch block. The effect of interventricular asynchrony. Circulation. 1989 Apr;79(4):845–853. doi: 10.1161/01.cir.79.4.845. [DOI] [PubMed] [Google Scholar]
  17. Haldeman G. A., Croft J. B., Giles W. H., Rashidee A. Hospitalization of patients with heart failure: National Hospital Discharge Survey, 1985 to 1995. Am Heart J. 1999 Feb;137(2):352–360. doi: 10.1053/hj.1999.v137.95495. [DOI] [PubMed] [Google Scholar]
  18. Havranek Edward P., Masoudi Frederick A., Westfall Kelly A., Wolfe Pam, Ordin Diana L., Krumholz Harlan M. Spectrum of heart failure in older patients: results from the National Heart Failure project. Am Heart J. 2002 Mar;143(3):412–417. doi: 10.1067/mhj.2002.120773. [DOI] [PubMed] [Google Scholar]
  19. Hochleitner M., Hörtnagl H., Ng C. K., Hörtnagl H., Gschnitzer F., Zechmann W. Usefulness of physiologic dual-chamber pacing in drug-resistant idiopathic dilated cardiomyopathy. Am J Cardiol. 1990 Jul 15;66(2):198–202. doi: 10.1016/0002-9149(90)90588-r. [DOI] [PubMed] [Google Scholar]
  20. Innes D., Leitch J. W., Fletcher P. J. VDD pacing at short atrioventricular intervals does not improve cardiac output in patients with dilated heart failure. Pacing Clin Electrophysiol. 1994 May;17(5 Pt 1):959–965. doi: 10.1111/j.1540-8159.1994.tb01439.x. [DOI] [PubMed] [Google Scholar]
  21. Jong Philip, Vowinckel Erika, Liu Peter P., Gong Yanyan, Tu Jack V. Prognosis and determinants of survival in patients newly hospitalized for heart failure: a population-based study. Arch Intern Med. 2002 Aug 12;162(15):1689–1694. doi: 10.1001/archinte.162.15.1689. [DOI] [PubMed] [Google Scholar]
  22. Kass D. A., Chen C. H., Curry C., Talbot M., Berger R., Fetics B., Nevo E. Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation. 1999 Mar 30;99(12):1567–1573. doi: 10.1161/01.cir.99.12.1567. [DOI] [PubMed] [Google Scholar]
  23. Kerwin W. F., Botvinick E. H., O'Connell J. W., Merrick S. H., DeMarco T., Chatterjee K., Scheibly K., Saxon L. A. Ventricular contraction abnormalities in dilated cardiomyopathy: effect of biventricular pacing to correct interventricular dyssynchrony. J Am Coll Cardiol. 2000 Apr;35(5):1221–1227. doi: 10.1016/s0735-1097(00)00555-6. [DOI] [PubMed] [Google Scholar]
  24. Le Rest C., Couturier O., Turzo A., Guillo P., Bizais Y., Etienne Y., Blanc J. J., Narula J. Use of left ventricular pacing in heart failure: evaluation by gated blood pool imaging. J Nucl Cardiol. 1999 Nov-Dec;6(6):651–656. doi: 10.1016/s1071-3581(99)90103-4. [DOI] [PubMed] [Google Scholar]
  25. Leclercq C., Cazeau S., Le Breton H., Ritter P., Mabo P., Gras D., Pavin D., Lazarus A., Daubert J. C. Acute hemodynamic effects of biventricular DDD pacing in patients with end-stage heart failure. J Am Coll Cardiol. 1998 Dec;32(7):1825–1831. doi: 10.1016/s0735-1097(98)00492-6. [DOI] [PubMed] [Google Scholar]
  26. Leclercq Christophe, Faris Owen, Tunin Richard, Johnson Jennifer, Kato Ritsuchi, Evans Frank, Spinelli Julio, Halperin Henry, McVeigh Elliot, Kass David A. Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block. Circulation. 2002 Oct 1;106(14):1760–1763. doi: 10.1161/01.cir.0000035037.11968.5c. [DOI] [PubMed] [Google Scholar]
  27. McMurray J. J., Stewart S. Epidemiology, aetiology, and prognosis of heart failure. Heart. 2000 May;83(5):596–602. doi: 10.1136/heart.83.5.596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Moore T. D., Frenneaux M. P., Sas R., Atherton J. J., Morris-Thurgood J. A., Smith E. R., Tyberg J. V., Belenkie I. Ventricular interaction and external constraint account for decreased stroke work during volume loading in CHF. Am J Physiol Heart Circ Physiol. 2001 Dec;281(6):H2385–H2391. doi: 10.1152/ajpheart.2001.281.6.H2385. [DOI] [PubMed] [Google Scholar]
  29. Morris-Thurgood J. A., Turner M. S., Nightingale A. K., Masani N., Mumford C., Frenneaux M. P. Pacing in heart failure: improved ventricular interaction in diastole rather than systolic re-synchronization. Europace. 2000 Oct;2(4):271–276. doi: 10.1053/eupc.2000.0133. [DOI] [PubMed] [Google Scholar]
  30. Saxon Leslie A., De Marco Teresa, Schafer Jill, Chatterjee Kanu, Kumar Uday N., Foster Elyse, VIGOR Congestive Heart Failure Investigators Effects of long-term biventricular stimulation for resynchronization on echocardiographic measures of remodeling. Circulation. 2002 Mar 19;105(11):1304–1310. doi: 10.1161/hc1102.105730. [DOI] [PubMed] [Google Scholar]
  31. Turner M. S., Bleasdale R. A., Mumford C. E., Frenneaux M. P., Morris-Thurgood J. A. Left ventricular pacing improves haemodynamic variables in patients with heart failure with a normal QRS duration. Heart. 2004 May;90(5):502–505. doi: 10.1136/hrt.2003.011759. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Turner Mark S., Bleasdale Rob A., Vinereanu Dragos, Mumford Catherine E., Paul Vince, Fraser Alan G., Frenneaux Michael P. Electrical and mechanical components of dyssynchrony in heart failure patients with normal QRS duration and left bundle-branch block: impact of left and biventricular pacing. Circulation. 2004 May 17;109(21):2544–2549. doi: 10.1161/01.CIR.0000131184.40893.40. [DOI] [PubMed] [Google Scholar]
  33. Verbeek Xander A. A. M., Vernooy Kevin, Peschar Maaike, Van Der Nagel Theo, Van Hunnik Arne, Prinzen Frits W. Quantification of interventricular asynchrony during LBBB and ventricular pacing. Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1370–H1378. doi: 10.1152/ajpheart.00051.2002. [DOI] [PubMed] [Google Scholar]
  34. Yu C-M, Lin H., Zhang Q., Sanderson J. E. High prevalence of left ventricular systolic and diastolic asynchrony in patients with congestive heart failure and normal QRS duration. Heart. 2003 Jan;89(1):54–60. doi: 10.1136/heart.89.1.54. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Yu Cheuk-Man, Chau Elaine, Sanderson John E., Fan Katherine, Tang Man-Oi, Fung Wing-Hong, Lin Hong, Kong Shun-Ling, Lam Yui-Ming, Hill Michael R. S. Tissue Doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure. Circulation. 2002 Jan 29;105(4):438–445. doi: 10.1161/hc0402.102623. [DOI] [PubMed] [Google Scholar]

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