Table 1.
Group no. | # of animals | 80E dose (μg) | NS1 dose (μg) | “mock” antigenb |
---|---|---|---|---|
1 | 15 | 0 | 0 | + |
2 | 15 | 0 | 1 | − |
3 | 15 | 1 | 0 | − |
4 | 15 | 1 | 1 | − |
5 | 15 | 10 | 0 | − |
6 | 15 | 10 | 1 | − |
All vaccines contained 12 μg of ISCOMATRIX® adjuvant per dose. Hamsters were vaccinated twice, subcutaneously, at a 4 week interval, and then challenged 2 weeks later.
An amount of “mock” antigen equivalent to what would be present in 10 μg of 80E was used.