Table 1.
Experimental design for the evaluation of a West Nile candidate vaccine 80E with or without the West Nile NS1 protein in groups of hamsters a
| Group no. | # of animals | 80E dose (μg) | NS1 dose (μg) | “mock” antigenb |
|---|---|---|---|---|
| 1 | 15 | 0 | 0 | + |
| 2 | 15 | 0 | 1 | − |
| 3 | 15 | 1 | 0 | − |
| 4 | 15 | 1 | 1 | − |
| 5 | 15 | 10 | 0 | − |
| 6 | 15 | 10 | 1 | − |
a
All vaccines contained 12 μg of ISCOMATRIX® adjuvant per dose. Hamsters were vaccinated twice, subcutaneously, at a 4 week interval, and then challenged 2 weeks later.
b
An amount of “mock” antigen equivalent to what would be present in 10 μg of 80E was used.