Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1990 May;136(5):1009–1019.

Malignant histiocytosis. A phenotypic and genotypic investigation.

G Cattoretti 1, A Villa 1, P Vezzoni 1, R Giardini 1, L Lombardi 1, F Rilke 1
PMCID: PMC1877429  PMID: 2349962

Abstract

Ten cases of malignant histiocytosis (MH) were evaluated for clinical and histopathologic features, phenotype, and rearrangement of T cell receptor (TCR) beta, gamma, and alpha and immunoglobulin (Ig) genes (7/10). All cases were HLA-DR+ and CD30-positive. Four cases had molecular evidence of T cell lineage such as TCR beta, gamma, and alpha rearrangements, and one additional case synthesized the cytoplasmic TCR beta chain. The remaining five cases did not show unequivocal T, B, natural killer (NK) cell, or macrophagic origin, and three of them had germline TCR and Ig genes. Ultrastructural analysis was not helpful for the definition of the cell lineage. Most myelomonocytic markers (MAC387, CD13, CD14, CD64, CD68) were either negative on the MH cells or were expressed on cells with rearranged TCR gene. Precursor (CD34, CD7) and NK (CD16, CD56, and CD57) cell markers were not found. The lineage of a number of cases of MH remains unresolved.

Full text

PDF
1009

Images in this article

1011Figure 1
on p.1011
1011Figure 2
on p.1011
1013Figure 3
on p.1013
1013Figure 4
on p.1013
1013Figure 5
on p.1013
1014Figure 6
on p.1014
1014Figure 7
on p.1014
1015Figure 8
on p.1015
1016Figure 9
on p.1016
1016Figure 10
on p.1016

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agnarsson B. A., Kadin M. E. Ki-1 positive large cell lymphoma. A morphologic and immunologic study of 19 cases. Am J Surg Pathol. 1988 Apr;12(4):264–274. doi: 10.1097/00000478-198804000-00002. [DOI] [PubMed] [Google Scholar]
  2. Cattoretti G., Berti E., Schiró R., D'Amato L., Valeggio C., Rilke F. Improved avidin-biotin-peroxidase complex (ABC) staining. Histochem J. 1988 Feb;20(2):75–80. doi: 10.1007/BF01746607. [DOI] [PubMed] [Google Scholar]
  3. Delsol G., Al Saati T., Gatter K. C., Gerdes J., Schwarting R., Caveriviere P., Rigal-Huguet F., Robert A., Stein H., Mason D. Y. Coexpression of epithelial membrane antigen (EMA), Ki-1, and interleukin-2 receptor by anaplastic large cell lymphomas. Diagnostic value in so-called malignant histiocytosis. Am J Pathol. 1988 Jan;130(1):59–70. [PMC free article] [PubMed] [Google Scholar]
  4. Erber W. N., Breton-Gorius J., Villeval J. L., Oscier D. G., Bai Y., Mason D. Y. Detection of cells of megakaryocyte lineage in haematological malignancies by immuno-alkaline phosphatase labelling cell smears with a panel of monoclonal antibodies. Br J Haematol. 1987 Jan;65(1):87–94. doi: 10.1111/j.1365-2141.1987.tb06140.x. [DOI] [PubMed] [Google Scholar]
  5. Foa R., Casorati G., Giubellino M. C., Basso G., Schirò R., Pizzolo G., Lauria F., Lefranc M. P., Rabbitts T. H., Migone N. Rearrangements of immunoglobulin and T cell receptor beta and gamma genes are associated with terminal deoxynucleotidyl transferase expression in acute myeloid leukemia. J Exp Med. 1987 Mar 1;165(3):879–890. doi: 10.1084/jem.165.3.879. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Isaacson P. G., O'Connor N. T., Spencer J., Bevan D. H., Connolly C. E., Kirkham N., Pollock D. J., Wainscoat J. S., Stein H., Mason D. Y. Malignant histiocytosis of the intestine: a T-cell lymphoma. Lancet. 1985 Sep 28;2(8457):688–691. doi: 10.1016/s0140-6736(85)92930-7. [DOI] [PubMed] [Google Scholar]
  7. Jones D. B., Gerdes J., Stein H., Wright D. H. An investigation of Ki-1 positive large cell lymphoma with antibodies reactive with tissue macrophages. Hematol Oncol. 1986 Oct-Dec;4(4):315–322. doi: 10.1002/hon.2900040408. [DOI] [PubMed] [Google Scholar]
  8. Kadin M. E., Sako D., Berliner N., Franklin W., Woda B., Borowitz M., Ireland K., Schweid A., Herzog P., Lange B. Childhood Ki-1 lymphoma presenting with skin lesions and peripheral lymphadenopathy. Blood. 1986 Nov;68(5):1042–1049. [PubMed] [Google Scholar]
  9. Kamesaki H., Koya M., Miwa H., Kita K., Doi S., Tatsumi E., Hatanaka M., Uchino H. Malignant histiocytosis with rearrangement of the heavy chain gene and evidence of monocyte-macrophage lineage. Cancer. 1988 Oct 1;62(7):1306–1309. doi: 10.1002/1097-0142(19881001)62:7<1306::aid-cncr2820620711>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  10. Korsmeyer S. J., Arnold A., Bakhshi A., Ravetch J. V., Siebenlist U., Hieter P. A., Sharrow S. O., LeBien T. W., Kersey J. H., Poplack D. G. Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. J Clin Invest. 1983 Feb;71(2):301–313. doi: 10.1172/JCI110770. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lanier L. L., Phillips J. H., Hackett J., Jr, Tutt M., Kumar V. Natural killer cells: definition of a cell type rather than a function. J Immunol. 1986 Nov 1;137(9):2735–2739. [PubMed] [Google Scholar]
  12. Lefranc M. P., Rabbitts T. H. Two tandemly organized human genes encoding the T-cell gamma constant-region sequences show multiple rearrangement in different T-cell types. Nature. 1985 Aug 1;316(6027):464–466. doi: 10.1038/316464a0. [DOI] [PubMed] [Google Scholar]
  13. Lombardi L., Carbone A., Pilotti S., Rilke F. Malignant histiocytosis: a histological and ultrastructural study of lymph nodes in six cases. Histopathology. 1978 Sep;2(5):315–328. doi: 10.1111/j.1365-2559.1978.tb01724.x. [DOI] [PubMed] [Google Scholar]
  14. Mathieu-Mahul D., Caubet J. F., Bernheim A., Mauchauffé M., Palmer E., Berger R., Larsen C. J. Molecular cloning of a DNA fragment from human chromosome 14(14q11) involved in T-cell malignancies. EMBO J. 1985 Dec 16;4(13A):3427–3433. doi: 10.1002/j.1460-2075.1985.tb04100.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. McBride O. W., Hieter P. A., Hollis G. F., Swan D., Otey M. C., Leder P. Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes. J Exp Med. 1982 May 1;155(5):1480–1490. doi: 10.1084/jem.155.5.1480. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mirro J., Antoun G. R., Zipf T. F., Melvin S., Stass S. The E rosette-associated antigen of T cells can be identified on blasts from patients with acute myeloblastic leukemia. Blood. 1985 Feb;65(2):363–367. [PubMed] [Google Scholar]
  17. Morgan R., Smith S. D., Hecht B. K., Christy V., Mellentin J. D., Warnke R., Cleary M. L. Lack of involvement of the c-fms and N-myc genes by chromosomal translocation t(2;5)(p23;q35) common to malignancies with features of so-called malignant histiocytosis. Blood. 1989 Jun;73(8):2155–2164. [PubMed] [Google Scholar]
  18. O'Connor N. T., Stein H., Gatter K. C., Wainscoat J. S., Crick J., Al Saati T., Falini B., Delsol G., Mason D. Y. Genotypic analysis of large cell lymphomas which express the Ki-1 antigen. Histopathology. 1987 Jul;11(7):733–740. doi: 10.1111/j.1365-2559.1987.tb02687.x. [DOI] [PubMed] [Google Scholar]
  19. Rilke F., Carbone A., Musumeci R., Pilotti S., De Lena M., Bonadonna G. Malignant histiocytosis: a clinicopathologic study of 18 consecutive cases. Tumori. 1978 Apr 30;64(2):211–227. doi: 10.1177/030089167806400211. [DOI] [PubMed] [Google Scholar]
  20. Royston I., Majda J. A., Baird S. M., Meserve B. L., Griffiths J. C. Human T cell antigens defined by monoclonal antibodies: the 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin. J Immunol. 1980 Aug;125(2):725–731. [PubMed] [Google Scholar]
  21. Stein H., Gatter K., Asbahr H., Mason D. Y. Use of freeze-dried paraffin-embedded sections for immunohistologic staining with monoclonal antibodies. Lab Invest. 1985 Jun;52(6):676–683. [PubMed] [Google Scholar]
  22. Stein H., Mason D. Y., Gerdes J., O'Connor N., Wainscoat J., Pallesen G., Gatter K., Falini B., Delsol G., Lemke H. The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood. 1985 Oct;66(4):848–858. [PubMed] [Google Scholar]
  23. Su I. J., Balk S. P., Kadin M. E. Molecular basis for the aberrant expression of T cell antigens in postthymic T cell malignancies. Am J Pathol. 1988 Aug;132(2):192–198. [PMC free article] [PubMed] [Google Scholar]
  24. Vezzoni P., Cairo G., Pozzi M. R., Bardella L., Schiaffonati L., Giardini R., Rilke F., Delia D., Biunno I. The contribution of molecular biology in the diagnosis of human lymphomas. Diagn Immunol. 1986;4(5):247–252. [PubMed] [Google Scholar]
  25. Weiss L. M., Picker L. J., Copenhaver C. M., Warnke R. A., Sklar J. Large-cell hematolymphoid neoplasms of uncertain lineage. Hum Pathol. 1988 Aug;19(8):967–973. doi: 10.1016/s0046-8177(88)80014-5. [DOI] [PubMed] [Google Scholar]
  26. Weiss L. M., Picker L. J., Grogan T. M., Warnke R. A., Sklar J. Absence of clonal beta and gamma T-cell receptor gene rearrangements in a subset of peripheral T-cell lymphomas. Am J Pathol. 1988 Mar;130(3):436–442. [PMC free article] [PubMed] [Google Scholar]
  27. Weiss L. M., Trela M. J., Cleary M. L., Turner R. R., Warnke R. A., Sklar J. Frequent immunoglobulin and T-cell receptor gene rearrangements in "histiocytic" neoplasms. Am J Pathol. 1985 Dec;121(3):369–373. [PMC free article] [PubMed] [Google Scholar]
  28. Wood G. S., Warner N. L., Warnke R. A. Anti-Leu-3/T4 antibodies react with cells of monocyte/macrophage and Langerhans lineage. J Immunol. 1983 Jul;131(1):212–216. [PubMed] [Google Scholar]
  29. Yanagi Y., Chan A., Chin B., Minden M., Mak T. W. Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line. Proc Natl Acad Sci U S A. 1985 May;82(10):3430–3434. doi: 10.1073/pnas.82.10.3430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Yoshikai Y., Anatoniou D., Clark S. P., Yanagi Y., Sangster R., Van den Elsen P., Terhorst C., Mak T. W. Sequence and expression of transcripts of the human T-cell receptor beta-chain genes. Nature. 1984 Dec 6;312(5994):521–524. doi: 10.1038/312521a0. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES