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. 1990 Jan;136(1):17–21.

Cutaneous T-cell lymphoma cells employ a restricted range of T-cell antigen receptor variable region genes.

A S Jack 1, A W Boylston 1, S Carrel 1, I Grigor 1
PMCID: PMC1877451  PMID: 2297046

Abstract

Monoclonal antibodies that recognize the proteins specified by two families of T-cell antigen receptor variable region genes were assessed as clonal markers in cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome). About 3% to 5% of tumors were expected to react with each antibody. However, 10 of 16 cases studied reacted with MAbs specific for the V beta 8 gene family. All the positive cases were examples of the plaque or tumor stages of CTCL. None of the cases of eczematoid or premycotic CTCL showed uniform reactivity with these antibodies. Unexpected use of one particular V gene family raises the possibility that CTCL derives from a distinct subpopulation of antigen- or virus-selected T cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acuto O., Campen T. J., Royer H. D., Hussey R. E., Poole C. B., Reinherz E. L. Molecular analysis of T cell receptor (Ti) variable region (V) gene expression. Evidence that a single Ti beta V gene family can be used in formation of V domains on phenotypically and functionally diverse T cell populations. J Exp Med. 1985 Jun 1;161(6):1326–1343. doi: 10.1084/jem.161.6.1326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beck S., Barrell B. G. Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens. Nature. 1988 Jan 21;331(6153):269–272. doi: 10.1038/331269a0. [DOI] [PubMed] [Google Scholar]
  3. Borst J., de Vries E., Spits H., de Vries J. E., Boylston A. W., Matthews E. A. Complexity of T cell receptor recognition sites for defined alloantigens. J Immunol. 1987 Sep 15;139(6):1952–1959. [PubMed] [Google Scholar]
  4. Boylston A. W., Borst J., Yssel H., Blanchard D., Spits H., de Vries J. E. Properties of a panel of monoclonal antibodies which react with the human T cell antigen receptor on the leukemic line HPB-ALL and a subset of normal peripheral blood T lymphocytes. J Immunol. 1986 Jul 15;137(2):741–744. [PubMed] [Google Scholar]
  5. Boylston A. W., Cosford P. Growth of normal human T lymphocytes induced by monoclonal antibody to the T cell antigen receptor. Eur J Immunol. 1985 Jul;15(7):738–742. doi: 10.1002/eji.1830150719. [DOI] [PubMed] [Google Scholar]
  6. Boylston A. W., Francis N. D. Does it matter which cells are infected by the human immunodeficiency virus type 1? J Pathol. 1988 Oct;156(2):93–96. doi: 10.1002/path.1711560202. [DOI] [PubMed] [Google Scholar]
  7. Carrel S., Isler P., Schreyer M., Vacca A., Salvi S., Giuffre L., Mach J. P. Expression on human thymocytes of the idiotypic structures (Ti) from two leukemia T cell lines Jurkat and HPB-ALL. Eur J Immunol. 1986 Jun;16(6):649–652. doi: 10.1002/eji.1830160610. [DOI] [PubMed] [Google Scholar]
  8. Clark D. M., Boylston A. W., Hall P. A., Carrel S. Antibodies to T cell antigen receptor beta chain families detect monoclonal T cell proliferation. Lancet. 1986 Oct 11;2(8511):835–837. doi: 10.1016/s0140-6736(86)92870-9. [DOI] [PubMed] [Google Scholar]
  9. Concannon P., Pickering L. A., Kung P., Hood L. Diversity and structure of human T-cell receptor beta-chain variable region genes. Proc Natl Acad Sci U S A. 1986 Sep;83(17):6598–6602. doi: 10.1073/pnas.83.17.6598. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Davis M. M., Bjorkman P. J. T-cell antigen receptor genes and T-cell recognition. Nature. 1988 Aug 4;334(6181):395–402. doi: 10.1038/334395a0. [DOI] [PubMed] [Google Scholar]
  11. Hengartner H., Odermatt B., Schneider R., Schreyer M., Wälle G., MacDonald H. R., Zinkernagel R. M. Deletion of self-reactive T cells before entry into the thymus medulla. Nature. 1988 Nov 24;336(6197):388–390. doi: 10.1038/336388a0. [DOI] [PubMed] [Google Scholar]
  12. Kappler J. W., Staerz U., White J., Marrack P. C. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature. 1988 Mar 3;332(6159):35–40. doi: 10.1038/332035a0. [DOI] [PubMed] [Google Scholar]
  13. Kappler J., Kotzin B., Herron L., Gelfand E. W., Bigler R. D., Boylston A., Carrel S., Posnett D. N., Choi Y., Marrack P. V beta-specific stimulation of human T cells by staphylococcal toxins. Science. 1989 May 19;244(4906):811–813. doi: 10.1126/science.2524876. [DOI] [PubMed] [Google Scholar]
  14. Kimura N., Toyonaga B., Yoshikai Y., Triebel F., Debre P., Minden M. D., Mak T. W. Sequences and diversity of human T cell receptor beta chain variable region genes. J Exp Med. 1986 Sep 1;164(3):739–750. doi: 10.1084/jem.164.3.739. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Klinman N. R., Linton P. J. The clonotype repertoire of B cell subpopulations. Adv Immunol. 1988;42:1–93. doi: 10.1016/s0065-2776(08)60842-1. [DOI] [PubMed] [Google Scholar]
  16. Knobler R. M., Edelson R. L. Cutaneous T cell lymphoma. Med Clin North Am. 1986 Jan;70(1):109–138. doi: 10.1016/s0025-7125(16)30972-5. [DOI] [PubMed] [Google Scholar]
  17. Kronenberg M., Siu G., Hood L. E., Shastri N. The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. Annu Rev Immunol. 1986;4:529–591. doi: 10.1146/annurev.iy.04.040186.002525. [DOI] [PubMed] [Google Scholar]
  18. Lai E., Concannon P., Hood L. Conserved organization of the human and murine T-cell receptor beta-gene families. Nature. 1988 Feb 11;331(6156):543–546. doi: 10.1038/331543a0. [DOI] [PubMed] [Google Scholar]
  19. MacKie R. M. Initial event in mycosis fungoides of the skin is viral infection of epidermal Langerhans cells. Lancet. 1981 Aug 8;2(8241):283–285. doi: 10.1016/s0140-6736(81)90529-8. [DOI] [PubMed] [Google Scholar]
  20. Siu G., Strauss E. C., Lai E., Hood L. E. Analysis of a human V beta gene subfamily. J Exp Med. 1986 Nov 1;164(5):1600–1614. doi: 10.1084/jem.164.5.1600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Sorger S. B., Hedrick S. M., Fink P. J., Bookman M. A., Matis L. A. Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c. J Exp Med. 1987 Feb 1;165(2):279–301. doi: 10.1084/jem.165.2.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Sterry W. Mycosis fungoides. Curr Top Pathol. 1985;74:167–223. doi: 10.1007/978-3-642-69574-2_5. [DOI] [PubMed] [Google Scholar]
  23. White J., Herman A., Pullen A. M., Kubo R., Kappler J. W., Marrack P. The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell. 1989 Jan 13;56(1):27–35. doi: 10.1016/0092-8674(89)90980-x. [DOI] [PubMed] [Google Scholar]

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