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. 1990 Mar;136(3):487–490.

The demonstration of vasodilator activity of pancreatic amylin amide in the rabbit.

S D Brain 1, S Wimalawansa 1, I MacIntyre 1, T J Williams 1
PMCID: PMC1877478  PMID: 2316620

Abstract

Amylin amide, a 37-amino acid peptide that is a major component of amyloid deposits in the diabetic pancreas, possesses vasodilator activity. Human synthetic amylin amide (30 to 300 pmol/site) stimulated a dose-dependent increase in blood flow after intradermal injection in rabbit skin. Amylin amide was 100 times less active than the structurally related potent vasodilator neuropeptide calcitonin gene-related peptide. Amylin amide did not induce edema formation; however, as a consequence of its vasodilator activity, amylin amide potentiated edema formation induced in rabbit skin by bradykinin. The intravenous injection of amylin amide (10 nmol) caused a systemic drop in blood pressure. This study demonstrates that amylin amide elicits vasodilator responses in vivo. It is possible that the release of amylin amide from the pancreas in type II diabetes could lead to changes in vascular tone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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