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. 1990 Mar;136(3):513–520.

Protection against membrane-mediated cytotoxicity by calcium and zinc.

D Mahadevan 1, A Ndirika 1, J Vincent 1, L Bashford 1, T Chambers 1, C Pasternak 1
PMCID: PMC1877503  PMID: 2156428

Abstract

Injection of S. aureus alpha toxin or ultraviolet-inactivated Sendai virus into the mammary gland of lactating mice leads to cytopathic changes in the alveolar cells compatible with a breakdown of their permeability barrier. Simultaneous administration of Ca2+ or Zn2+ prevents such changes, as it does when added to alveolar cells in vitro. It is concluded that increased levels of Zn2+ (and under certain conditions of Ca2+) may exert a protective role that is clinically significant.

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Selected References

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