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. 1993 Apr;37(4):750–753. doi: 10.1128/aac.37.4.750

Antimicrobial susceptibility of Acinetobacter species.

H Seifert 1, R Baginski 1, A Schulze 1, G Pulverer 1
PMCID: PMC187751  PMID: 8494371

Abstract

The in vitro activities of 16 antimicrobial agents against 180 Acinetobacter strains isolated from blood cultures (n = 162), central venous catheters (n = 11), and cerebrospinal fluids (n = 7) were studied. MICs were determined by a microtiter broth dilution method. Considerable differences in antimicrobial drug susceptibility against strains belonging to different species could be demonstrated. Acinetobacter baumannii isolates (n = 108) were generally more resistant than isolates identified as species other than A. baumannii. Multidrug resistance was common among A. baumannii isolates. Of the antimicrobial agents tested, imipenem was highly active against all A. baumannii isolates, and the other agents tested were only moderately active or inactive. Good activity against Acinetobacter species strain 3 was demonstrated for imipenem, amikacin, and ciprofloxacin. Most of the strains belonging to other species were susceptible to imipenem, ciprofloxacin, expanded-spectrum cephalosporins, amoxicillin-clavulanate, and the aminoglycosides but were resistant to ampicillin and older cephalosporins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Al-Khoja M. S., Darrell J. H. The skin as the source of Acinetobacter and Moraxella species occurring in blood cultures. J Clin Pathol. 1979 May;32(5):497–499. doi: 10.1136/jcp.32.5.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baumann P. Isolation of Acinetobacter from soil and water. J Bacteriol. 1968 Jul;96(1):39–42. doi: 10.1128/jb.96.1.39-42.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bergogne-Berezin E., Joly-Guillou M. L. An underestimated nosocomial pathogen, Acinetobacter calcoaceticus. J Antimicrob Chemother. 1985 Nov;16(5):535–538. doi: 10.1093/jac/16.5.535. [DOI] [PubMed] [Google Scholar]
  4. Bergogne-Berezin E., Joly-Guillou M. L. Comparative activity of imipenem, ceftazidime and cefotaxime against Acinetobacter calcoaceticus. J Antimicrob Chemother. 1986 Dec;18 (Suppl E):35–39. doi: 10.1093/jac/18.supplement_e.35. [DOI] [PubMed] [Google Scholar]
  5. Bergogne-Bérézin E., Joly-Guillou M. L., Vieu J. F. Epidemiology of nosocomial infections due to Acinetobacter calcoaceticus. J Hosp Infect. 1987 Sep;10(2):105–113. doi: 10.1016/0195-6701(87)90135-6. [DOI] [PubMed] [Google Scholar]
  6. Bouvet P. J., Grimont P. A. Identification and biotyping of clinical isolates of Acinetobacter. Ann Inst Pasteur Microbiol. 1987 Sep-Oct;138(5):569–578. doi: 10.1016/0769-2609(87)90042-1. [DOI] [PubMed] [Google Scholar]
  7. Freney J., Bouvet P. J., Tixier C. Identification et détermination de la sensibilité aux antibiotiques de 31 souches cliniques d'Acinetobacter autres que A. baumannii. Ann Biol Clin (Paris) 1989;47(1):41–44. [PubMed] [Google Scholar]
  8. Glew R. H., Moellering R. C., Jr, Kunz L. J. Infections with Acinetobacter calcoaceticus (Herellea vaginicola): clinical and laboratory studies. Medicine (Baltimore) 1977 Mar;56(2):79–97. doi: 10.1097/00005792-197703000-00001. [DOI] [PubMed] [Google Scholar]
  9. Hercouet H., Bousser J., Donnio P. Y., Avril J. L. Activité in vitro des antibiotiques sur les souches hospitalières de Acinetobacter baumanii. Pathol Biol (Paris) 1989 Jun;37(5 Pt 2):612–616. [PubMed] [Google Scholar]
  10. Joly-Guillo M. L., Vallée E., Bergogne-Bérézin E., Philippon A. Distribution of beta-lactamases and phenotype analysis in clinical strains of Acinetobacter calcoaceticus. J Antimicrob Chemother. 1988 Nov;22(5):597–604. doi: 10.1093/jac/22.5.597. [DOI] [PubMed] [Google Scholar]
  11. Joly-Guillou M. L., Bergogne-Berezin E. Présence d'une beta-lactamase à spectre élargi chez Acinetobacter baumanii. Presse Med. 1990 Apr 7;19(14):672–673. [PubMed] [Google Scholar]
  12. Joly-Guillou M. L., Bergogne-Berezin E., Vieu J. F. Epidémiologie et résistance aux antibiotiques des Acinetobacter en milieu hospitalier. Bilan de 5 années. Presse Med. 1990 Mar 3;19(8):357–361. [PubMed] [Google Scholar]
  13. Joly-Guillou M. L., Bergogne-Bérézin E. Activité comparative in vitro du ceftizoxime, de la ceftazidime et de l'imipenem sur Acinetobacter calcoaceticus. Pathol Biol (Paris) 1986 Jun;34(5 Pt 2):625–628. [PubMed] [Google Scholar]
  14. Lambert T., Gerbaud G., Courvalin P. Transferable amikacin resistance in Acinetobacter spp. due to a new type of 3'-aminoglycoside phosphotransferase. Antimicrob Agents Chemother. 1988 Jan;32(1):15–19. doi: 10.1128/aac.32.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Morohoshi T., Saito T. beta-Lactamase and beta-lactam antibiotics resistance in acinetobacter anitratum (syn: A. calcoaceticus). J Antibiot (Tokyo) 1977 Nov;30(11):969–973. doi: 10.7164/antibiotics.30.969. [DOI] [PubMed] [Google Scholar]
  16. Retailliau H. F., Hightower A. W., Dixon R. E., Allen J. R. Acinetobacter calcoaceticus: a nosocomial pathogen with an unusual seasonal pattern. J Infect Dis. 1979 Mar;139(3):371–375. doi: 10.1093/infdis/139.3.371. [DOI] [PubMed] [Google Scholar]
  17. Rolston K. V., Bodey G. P. In vitro susceptibility of Acinetobacter species to various antimicrobial agents. Antimicrob Agents Chemother. 1986 Nov;30(5):769–770. doi: 10.1128/aac.30.5.769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Tjernberg I. Antimicrobial susceptibility of Acinetobacter strains identified by DNA-DNA hybridization. APMIS. 1990 Apr;98(4):320–326. [PubMed] [Google Scholar]
  19. Traub W. H., Spohr M. Antimicrobial drug susceptibility of clinical isolates of Acinetobacter species (A. baumannii, A. haemolyticus, genospecies 3, and genospecies 6). Antimicrob Agents Chemother. 1989 Sep;33(9):1617–1619. doi: 10.1128/aac.33.9.1617. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Vallée E., Joly-Guillou M. L., Bergogne-Berezin E. Activité comparative de l'imipénème, du céfotaxime et de la ceftazidime vis-à-vis d'Acinetobacter calcoaceticus. Presse Med. 1990 Apr 4;19(13):588–591. [PubMed] [Google Scholar]

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