Abstract
Agar and broth microdilution MICs of RP 74501-RP 74502, a mixture of streptogramin antimicrobial agents that inhibited 90% of 22 Legionella strains tested, were 0.64 and 0.08 microgram/ml, respectively; respective erythromycin values were 1.0 and 0.12 microgram/ml. RP 74501-RP 74502 at 1 microgram/ml was more active than the same erythromycin concentration in a macrophage system for both L. pneumophila strains studied but at a lower concentration (0.25 microgram/ml) was much less active than erythromycin.
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Selected References
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- Desnottes J. F., Diallo N. Cellular uptake and intracellular bactericidal activity of RP 59500 in murine macrophages. J Antimicrob Chemother. 1992 Jul;30 (Suppl A):107–115. doi: 10.1093/jac/30.suppl_a.107. [DOI] [PubMed] [Google Scholar]
- Dubois J., Joly J. R. In-vitro activity of RP 59500, a new synergic antibacterial agent, against Legionella spp. J Antimicrob Chemother. 1992 Jul;30 (Suppl A):77–81. doi: 10.1093/jac/30.suppl_a.77. [DOI] [PubMed] [Google Scholar]
- Edelstein P. H., Edelstein M. A. In vitro activity of Ro 23-9424 against clinical isolates of Legionella species. Antimicrob Agents Chemother. 1992 Nov;36(11):2559–2561. doi: 10.1128/aac.36.11.2559. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Edelstein P. H., Edelstein M. A. WIN 57273 is bactericidal for Legionella pneumophila grown in alveolar macrophages. Antimicrob Agents Chemother. 1989 Dec;33(12):2132–2136. doi: 10.1128/aac.33.12.2132. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Edelstein P. H., Edelstein M. A., Weidenfeld J., Dorr M. B. In vitro activity of sparfloxacin (CI-978; AT-4140) for clinical Legionella isolates, pharmacokinetics in guinea pigs, and use to treat guinea pigs with L. pneumophila pneumonia. Antimicrob Agents Chemother. 1990 Nov;34(11):2122–2127. doi: 10.1128/aac.34.11.2122. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Maskell J. P., Sefton A. M., Yong J., Chi S. J., Williams J. D. Comparative in-vitro activity of erythromycin, vancomycin and pristinamycin. Infection. 1988;16(6):365–370. doi: 10.1007/BF01644551. [DOI] [PubMed] [Google Scholar]