Abstract
In an unselected series of 49 children with Wilms' tumour treated in 1969-74 the 5-year relapse-free survival and survival rates were 78% and 81%, respectively, whereas in the series of children treated in 1963-68 the corresponding rates were 49% and 70%. The significant improvement in the relapse-free survival rate was a result of adjuvant treatment with actinomycin D and vincristine (AMD + VCR), which, in some patients, eradicated occult metastatic disease. In the treatment of lung metastases the combination of whole-lung irradiation and maintained chemotherapy with AMD + VCR proved excessively toxic: in 5 of 11 patients acute diffuse pneumonitis developed, and it was fatal in 3. Adjuvant AMD + VCR therapy is advocated in all patients with Wilms' tumour except children less than 12 months old with a tumour of moderate size, limited to the kidney and completely resectable.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cassady J. R., Tefft M., Filler R. M., Jaffe N., Paed D., Hellman S. Considerations in the radiation therapy of Wilms' tumor. Cancer. 1973 Sep;32(3):598–608. doi: 10.1002/1097-0142(197309)32:3<598::aid-cncr2820320312>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
- Farber S. Chemotherapy in the treatment of leukemia and Wilms' tumor. JAMA. 1966 Nov 21;198(8):826–836. [PubMed] [Google Scholar]
- Jenkin R. D., Darte J. M., Jeffs R. D., Stephens C. A., Sonley M. J. Wilms' tumour: treatment of 113 patients from 1960 to 1971. Can Med Assoc J. 1975 Feb 8;112(3):308–313. [PMC free article] [PubMed] [Google Scholar]
- Jereb B., Sandstedt B. Structure and size prognosis in nephroblastoma. Cancer. 1973 Jun;31(6):1473–1481. doi: 10.1002/1097-0142(197306)31:6<1473::aid-cncr2820310624>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
- Sutow W. W., Sullivan M. P. Vincristine in primary treatment of Wilms' tumor. Tex Med. 1965 Nov;61(11):794–799. [PubMed] [Google Scholar]
- Wolff J. A. Advances in the treatment of Wilms' tumor. Cancer. 1975 Mar;35(3 Suppl):901–904. doi: 10.1002/1097-0142(197503)35:3+<901::aid-cncr2820350707>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
- Wolff J. A., Newton W. A., Jr, Krivit W., D'Angio G. J. Single versus multiple dose dactinomycin therapy of Wilms's tumor. A controlled co-operative study conducted by the Children's Cancer Study Group A (formerly Acute Leukemia Co-operative Chemotherapy Group A). N Engl J Med. 1968 Aug 8;279(6):290–294. doi: 10.1056/NEJM196808082790605. [DOI] [PubMed] [Google Scholar]