Abstract
Benzoyl peroxide, a powerful organic oxidizing agent, was applied topically according to a carefully developed technique to cutaneous ulcers of different types. The healing time was shortened greatly by the rapid development of healthy granulation tissue and the quick ingrowth of epithelium. Exceptionally large pressure ulcers with deep cavities, undercut edges and sinus tracts were sucessfully treated, as were stasis ulcers of long duration resistant to all other therapy. There were only 13 treatment failures among the 133 cases. The slow, sustained release of oxygen by benzoyl peroxide was though to be responsible for the success. The only complications were contact irritant dermatitis in 3% and contact allergic dermatitis in 2% of patients treated.
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- Altemeier W. A., Carter B. N. INFECTED BURNS WITH HEMORRHAGE. Ann Surg. 1942 Jun;115(6):1118–1124. doi: 10.1097/00000658-194206000-00021. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barr P. O., Enfors W., Eriksson G. Hyperbaric oxygen therapy in dermatology. Br J Dermatol. 1972 Jun;86(6):631–635. doi: 10.1111/j.1365-2133.1972.tb05080.x. [DOI] [PubMed] [Google Scholar]
- Fischer B. H. Topical hyperbaric oxygen treatment of pressure sores and skin ulcers. Lancet. 1969 Aug 23;2(7617):405–409. doi: 10.1016/s0140-6736(69)90113-5. [DOI] [PubMed] [Google Scholar]
- Johnson B. A., Meleney F. L. THE ANTISEPTIC AND DETOXIFYING ACTION OF ZINC PEROXIDE ON CERTAIN SURGICAL AEROBIC, ANAEROBIC AND MICRO-AEROPHILIC BACTERIA. Ann Surg. 1939 Jun;109(6):881–911. doi: 10.1097/00000658-193906000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meleney F. L., Harvey H. D. THE COMBINED USE OF ZINC PEROXIDE AND SULFANILAMIDE IN THE TREATMENT OF CHRONIC, UNDERMINING, BURROWING ULCERS DUE TO THE MICRO-AEROPHILIC HEMOLYTIC STREPTOCOCCUS. Ann Surg. 1939 Dec;110(6):1067–1094. doi: 10.1097/00000658-193912000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meleney F. L. ZINC PEROXIDE IN THE TREATMENT OF MICROAEROPHILIC AND ANAEROBIC INFECTIONS: WITH SPECIAL REFERENCE TO A GROUP OF CHRONIC, ULCERATIVE, BURROWING, NON-GANGRENOUS LESIONS OF THE ABDOMINAL WALL APPARENTLY DUE TO A MICRO-AEROPHILIC HAEMOLYTIC STREPTOCOCCUS. Ann Surg. 1935 Apr;101(4):997–1011. doi: 10.1097/00000658-193504000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morgan J. E. Topical therapy of pressure ulcers. Surg Gynecol Obstet. 1975 Dec;141(6):945–947. [PubMed] [Google Scholar]
- PACE W. E. A BENZOYL PEROXIDE-SULFUR CREAM FOR ACNE VULGARIS. Can Med Assoc J. 1965 Aug 7;93:252–254. [PMC free article] [PubMed] [Google Scholar]
- Reid M. R., Altemeier W. A. PEROXIDE OINTMENTS. Ann Surg. 1943 Oct;118(4):741–749. doi: 10.1097/00000658-194310000-00021. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHARRATT M., FRAZER A. C., FORBES O. C. STUDY OF THE BIOLOGICAL EFFECTS OF BENZOYL PEROXIDE. Food Cosmet Toxicol. 1964 Nov;2:527–538. doi: 10.1016/s0015-6264(64)80351-5. [DOI] [PubMed] [Google Scholar]