Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1993 May;37(5):1154–1157. doi: 10.1128/aac.37.5.1154

In vitro postantibiotic effects following multiple exposures of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli in pooled human cerebrospinal fluid and Mueller-Hinton broth.

J A Karlowsky 1, G G Zhanel 1, R J Davidson 1, S R Zieroth 1, D J Hoban 1
PMCID: PMC187920  PMID: 8517705

Abstract

Multiple exposures with cefotaxime in either Mueller-Hinton broth or cerebrospinal fluid had no effect on killing or the duration of postantibiotic effect (PAE) in Escherichia coli strains tested. However, upon multiple exposures in Mueller-Hinton broth, ciprofloxacin and gentamicin PAEs significantly decreased with a concomitant reduction in bacterial killing. A reduction in bacterial killing following multiple ciprofloxacin and gentamicin exposures was also seen with cerebrospinal fluid; however, the PAE was maintained.

Full text

PDF
1154

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Craig W. A., Ebert S. C. Killing and regrowth of bacteria in vitro: a review. Scand J Infect Dis Suppl. 1990;74:63–70. [PubMed] [Google Scholar]
  2. Davidson R. J., Zhanel G. G., Phillips R., Hoban D. J. Human serum enhances the postantibiotic effect of fluoroquinolones against Staphylococcus aureus. Antimicrob Agents Chemother. 1991 Jun;35(6):1261–1263. doi: 10.1128/aac.35.6.1261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gould I. M., Milne K., Harvey G., Jason C. Ionic binding, adaptive resistance and post-antibiotic effect of netilmicin and ciprofloxacin. J Antimicrob Chemother. 1991 Jun;27(6):741–748. doi: 10.1093/jac/27.6.741. [DOI] [PubMed] [Google Scholar]
  4. Guseo A. Classification of cells in the cerebrospinal fluid. A review. Eur Neurol. 1977;15(3):169–176. doi: 10.1159/000114808. [DOI] [PubMed] [Google Scholar]
  5. Kuenzi B., Segessenmann C., Gerber A. U. Postantibiotic effect of roxithromycin, erythromycin, and clindamycin against selected gram-positive bacteria and Haemophilus influenzae. J Antimicrob Chemother. 1987 Nov;20 (Suppl B):39–46. doi: 10.1093/jac/20.suppl_b.39. [DOI] [PubMed] [Google Scholar]
  6. Lowenthal A., Crols R., De Schutter E., Gheuens J., Karcher D., Noppe M., Tasnier A. Cerebrospinal fluid proteins in neurology. Int Rev Neurobiol. 1984;25:95–138. doi: 10.1016/s0074-7742(08)60678-9. [DOI] [PubMed] [Google Scholar]
  7. McDonald P. J., Craig W. A., Kunin C. M. Persistent effect of antibiotics on Staphylococcus aureus after exposure for limited periods of time. J Infect Dis. 1977 Feb;135(2):217–223. doi: 10.1093/infdis/135.2.217. [DOI] [PubMed] [Google Scholar]
  8. Zhanel G. G., Hoban D. J., Harding G. K. The postantibiotic effect: a review of in vitro and in vivo data. DICP. 1991 Feb;25(2):153–163. doi: 10.1177/106002809102500210. [DOI] [PubMed] [Google Scholar]
  9. Zhanel G. G., Karlowsky J. A., Davidson R. J., Hoban D. J. Effect of pooled human cerebrospinal fluid on the postantibiotic effects of cefotaxime, ciprofloxacin, and gentamicin against Escherichia coli. Antimicrob Agents Chemother. 1992 May;36(5):1136–1139. doi: 10.1128/aac.36.5.1136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Zhanel G. G., Karlowsky J. A., Davidson R. J., Hoban D. J. Influence of human urine on the in vitro activity and postantibiotic effect of ciprofloxacin against Escherichia coli. Chemotherapy. 1991;37(3):218–223. doi: 10.1159/000238857. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES