Abstract
Long-term studies on multiple plasma samples of 988 patients with carcinoma of entodermal origin indicate that, especially for patients with colorectal cancer, repeatedly elevated or rising carcinoembryonic antigen (CEA) values are a sign of poor prognosis when found preoperatively, postoperatively or during chemotherapy. Persistently elevated CEA values in postoperative patients apparently free of disease are a useful marker for early detection of recurrence or metastases. Normal CEA values are of little or no prognostic value.
Full text
PDF![769](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e46/1879415/573d0b522828/canmedaj01501-0074.png)
![770](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e46/1879415/ccedca49e6c5/canmedaj01501-0075.png)
![771](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e46/1879415/d6f74ca8efc9/canmedaj01501-0076.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Mach J. P., Jaeger P., Bertholet M. M., Ruegsegger C. H., Loosli R. M., Pettavel J. Detection of recurrence of large-bowel carcinoma by radioimmunoassay of circulating carcinoembryonic antigen (C.E.A.). Lancet. 1974 Sep 7;2(7880):535–540. doi: 10.1016/s0140-6736(74)91872-8. [DOI] [PubMed] [Google Scholar]
- Ravry M., Moertel C. G., Schutt A. J., Go V. L. Usefulness of serial serum carcinoembryonic antigen (CEA) determinations during anticancer therapy or long-term follow-up of gastrointestinal carcinoma. Cancer. 1974 Oct;34(4):1230–1234. doi: 10.1002/1097-0142(197410)34:4<1230::aid-cncr2820340432>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
- Skarin A. T., Delwiche R., Zamcheck N., Lokich J. J., Frei E., 3rd Carcinoembryonic antigen: clinical correlation with chemotherapy for metastatic gastrointestinal cancer. Cancer. 1974 May;33(5):1239–1245. doi: 10.1002/1097-0142(197405)33:5<1239::aid-cncr2820330508>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
- Zamcheck N. The present status of DEA in diagnosis, prognosis, and evaluation of therapy. Cancer. 1975 Dec;36(6 Suppl):2460–2468. doi: 10.1002/1097-0142(197512)36:6<2460::aid-cncr2820360631>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]