Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1993 Jun;37(6):1367–1369. doi: 10.1128/aac.37.6.1367

Aerosol amphotericin B for prevention of invasive pulmonary aspergillosis.

J Beyer 1, G Barzen 1, G Risse 1, C Weyer 1, K Miksits 1, K Dullenkopf 1, D Huhn 1, W Siegert 1
PMCID: PMC187968  PMID: 8328788

Abstract

The pharmacokinetics and applicability of aerosol amphotericin B administrations were studied in 40 neutropenic patients and 4 healthy volunteers. Particle size was measured and pulmonary deposition was demonstrated by radioisotope studies. Inhalations were easy to administer and were well tolerated, with minimal systemic absorption of the drug.

Full text

PDF
1367

Images in this article

1368Image
on p.1368
1369Image
on p.1369
1369Image
on p.1369

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Conneally E., Cafferkey M. T., Daly P. A., Keane C. T., McCann S. R. Nebulized amphotericin B as prophylaxis against invasive aspergillosis in granulocytopenic patients. Bone Marrow Transplant. 1990 Jun;5(6):403–406. [PubMed] [Google Scholar]
  2. Denning D. W., Stevens D. A. Antifungal and surgical treatment of invasive aspergillosis: review of 2,121 published cases. Rev Infect Dis. 1990 Nov-Dec;12(6):1147–1201. doi: 10.1093/clinids/12.6.1147. [DOI] [PubMed] [Google Scholar]
  3. Jeffery G. M., Beard M. E., Ikram R. B., Chua J., Allen J. R., Heaton D. C., Hart D. N., Schousboe M. I. Intranasal amphotericin B reduces the frequency of invasive aspergillosis in neutropenic patients. Am J Med. 1991 Jun;90(6):685–692. [PubMed] [Google Scholar]
  4. Jorgensen C. J., Dreyfus F., Vaixeler J., Guyomard S., Massiot C., Belanger C., Brunet F., Giraud T., Dupuis-Camay P. Failure of amphotericin B spray to prevent aspergillosis in granulocytopenic patients. Nouv Rev Fr Hematol. 1989;31(5):327–328. [PubMed] [Google Scholar]
  5. Karp J. E., Merz W. G., Charache P. Response to empiric amphotericin B during antileukemic therapy-induced granulocytopenia. Rev Infect Dis. 1991 Jul-Aug;13(4):592–599. doi: 10.1093/clinids/13.4.592. [DOI] [PubMed] [Google Scholar]
  6. Maschmeyer G., Link H., Hiddemann W., Meyer P., Helmerking M., Adam D. Interventional antimicrobial strategy in febrile neutropenic patients. Results of a multicenter study in 1,260 patients with hematological malignancies. The Interventional Antimicrobial Strategy Study Group, Paul Ehrlich Society for Chemotherapy. Onkologie. 1990 Feb;13(1):38–42. doi: 10.1159/000216717. [DOI] [PubMed] [Google Scholar]
  7. Meunier F. New methods for delivery of antifungal agents. Rev Infect Dis. 1989 Nov-Dec;11 (Suppl 7):S1605–S1612. doi: 10.1093/clinids/11.supplement_7.s1605. [DOI] [PubMed] [Google Scholar]
  8. Myers S. E., Devine S. M., Topper R. L., Ondrey M., Chandler C., O'Toole K., Williams S. F., Larson R. A., Geller R. B. A pilot study of prophylactic aerosolized amphotericin B in patients at risk for prolonged neutropenia. Leuk Lymphoma. 1992 Oct;8(3):229–233. doi: 10.3109/10428199209054909. [DOI] [PubMed] [Google Scholar]
  9. Niki Y., Bernard E. M., Schmitt H. J., Tong W. P., Edwards F. F., Armstrong D. Pharmacokinetics of aerosol amphotericin B in rats. Antimicrob Agents Chemother. 1990 Jan;34(1):29–32. doi: 10.1128/aac.34.1.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Nilsson-Ehle I., Yoshikawa T. T., Edwards J. E., Schotz M. C., Guze L. B. Quantitation of amphotericin B with use of high-pressure liquid chromatography. J Infect Dis. 1977 Mar;135(3):414–422. doi: 10.1093/infdis/135.3.414. [DOI] [PubMed] [Google Scholar]
  11. Pannuti C. S., Gingrich R. D., Pfaller M. A., Wenzel R. P. Nosocomial pneumonia in adult patients undergoing bone marrow transplantation: a 9-year study. J Clin Oncol. 1991 Jan;9(1):77–84. doi: 10.1200/JCO.1991.9.1.77. [DOI] [PubMed] [Google Scholar]
  12. Rhame F. S. Prevention of nosocomial aspergillosis. J Hosp Infect. 1991 Jun;18 (Suppl A):466–472. doi: 10.1016/0195-6701(91)90058-g. [DOI] [PubMed] [Google Scholar]
  13. Rousey S. R., Russler S., Gottlieb M., Ash R. C. Low-dose amphotericin B prophylaxis against invasive Aspergillus infections in allogeneic marrow transplantation. Am J Med. 1991 Nov;91(5):484–492. doi: 10.1016/0002-9343(91)90184-y. [DOI] [PubMed] [Google Scholar]
  14. Schmitt H. J., Bernard E. M., Häuser M., Armstrong D. Aerosol amphotericin B is effective for prophylaxis and therapy in a rat model of pulmonary aspergillosis. Antimicrob Agents Chemother. 1988 Nov;32(11):1676–1679. doi: 10.1128/aac.32.11.1676. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sherertz R. J., Belani A., Kramer B. S., Elfenbein G. J., Weiner R. S., Sullivan M. L., Thomas R. G., Samsa G. P. Impact of air filtration on nosocomial Aspergillus infections. Unique risk of bone marrow transplant recipients. Am J Med. 1987 Oct;83(4):709–718. doi: 10.1016/0002-9343(87)90902-8. [DOI] [PubMed] [Google Scholar]
  16. Thunnissen P. L., Sizoo W., Hendriks W. D. Safety and efficacy of itraconazole in prevention of fungal infections in neutropenic patients. Neth J Med. 1991 Aug;39(1-2):84–91. [PubMed] [Google Scholar]
  17. Walsh T. J., Dixon D. M. Nosocomial aspergillosis: environmental microbiology, hospital epidemiology, diagnosis and treatment. Eur J Epidemiol. 1989 Jun;5(2):131–142. doi: 10.1007/BF00156818. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES