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. 1993 Jun;37(6):1387–1389. doi: 10.1128/aac.37.6.1387

Role of cephalosporinase in carbapenem resistance of clinical isolates of Pseudomonas aeruginosa.

X Y Zhou 1, M D Kitzis 1, L Gutmann 1
PMCID: PMC187975  PMID: 8328794

Abstract

With numerous imipenem-resistant clinical isolates of Pseudomonas aeruginosa as well as in vitro-selected resistant mutants, we have demonstrated, by a simple method with a powerful cephalosporinase inhibitor, BRL42715, the contribution of chromosomal cephalosporinase in resistance to imipenem in this species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Büscher K. H., Cullmann W., Dick W., Opferkuch W. Imipenem resistance in Pseudomonas aeruginosa resulting from diminished expression of an outer membrane protein. Antimicrob Agents Chemother. 1987 May;31(5):703–708. doi: 10.1128/aac.31.5.703. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Gutmann L., Williamson R., Moreau N., Kitzis M. D., Collatz E., Acar J. F., Goldstein F. W. Cross-resistance to nalidixic acid, trimethoprim, and chloramphenicol associated with alterations in outer membrane proteins of Klebsiella, Enterobacter, and Serratia. J Infect Dis. 1985 Mar;151(3):501–507. doi: 10.1093/infdis/151.3.501. [DOI] [PubMed] [Google Scholar]
  3. Lee E. H., Nicolas M. H., Kitzis M. D., Pialoux G., Collatz E., Gutmann L. Association of two resistance mechanisms in a clinical isolate of Enterobacter cloacae with high-level resistance to imipenem. Antimicrob Agents Chemother. 1991 Jun;35(6):1093–1098. doi: 10.1128/aac.35.6.1093. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Livermore D. M. Interplay of impermeability and chromosomal beta-lactamase activity in imipenem-resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1992 Sep;36(9):2046–2048. doi: 10.1128/aac.36.9.2046. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Mathew A., Harris A. M., Marshall M. J., Ross G. W. The use of analytical isoelectric focusing for detection and identification of beta-lactamases. J Gen Microbiol. 1975 May;88(1):169–178. doi: 10.1099/00221287-88-1-169. [DOI] [PubMed] [Google Scholar]
  6. Quinn J. P., Dudek E. J., DiVincenzo C. A., Lucks D. A., Lerner S. A. Emergence of resistance to imipenem during therapy for Pseudomonas aeruginosa infections. J Infect Dis. 1986 Aug;154(2):289–294. doi: 10.1093/infdis/154.2.289. [DOI] [PubMed] [Google Scholar]
  7. Raimondi A., Traverso A., Nikaido H. Imipenem- and meropenem-resistant mutants of Enterobacter cloacae and Proteus rettgeri lack porins. Antimicrob Agents Chemother. 1991 Jun;35(6):1174–1180. doi: 10.1128/aac.35.6.1174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Satake S., Yoneyama H., Nakae T. Role of OmpD2 and chromosomal beta-lactamase in carbapenem resistance in clinical isolates of Pseudomonas aeruginosa. J Antimicrob Chemother. 1991 Aug;28(2):199–207. doi: 10.1093/jac/28.2.199. [DOI] [PubMed] [Google Scholar]
  9. Trias J., Nikaido H. Outer membrane protein D2 catalyzes facilitated diffusion of carbapenems and penems through the outer membrane of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1990 Jan;34(1):52–57. doi: 10.1128/aac.34.1.52. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Yang Y. J., Livermore D. M. Interactions of meropenem with class I chromosomal beta-lactamases. J Antimicrob Chemother. 1989 Sep;24 (Suppl A):207–217. doi: 10.1093/jac/24.suppl_a.207. [DOI] [PubMed] [Google Scholar]

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