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. 1989 Aug;135(2):369–377.

Enhanced monocyte progenitor cell proliferation in bone marrow of hyperlipemic swine.

L E Averill 1, R C Meagher 1, R G Gerrity 1
PMCID: PMC1879926  PMID: 2675618

Abstract

This study demonstrated for the first time that bone marrow is a target of enhanced in vivo monocytopoiesis in hyperlipemia. A significantly greater number of bone marrow cells (BMC) were recovered per femur in swine fed a hyperlipemic (HL) diet compared with swine fed a normal (N) diet. In addition, a significantly elevated number of monocytic precursors proliferated in HL-swine compared with N-swine BMC cultures grown in standardized media in the absence of an exogenous source of colony stimulating factor (CSF). HL-swine sera stimulated a significant enhancement in the number of proliferating monocytic precursor cells, regardless of whether or not the BMC were from HL- or N-swine. In addition, HL-swine compared with N-swine BMC demonstrated an enhanced intrinsic capacity to form monocytic colonies in culture, irrespective of the source of swine sera used to stimulate growth.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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